Genomic News and Research

RSS

Microarray analysis could lead to better understanding of mechanisms underlying the genetic propensity toward excessive drinking

The meta analysis, which examined more than 4.5 million data points on more than 100 microarrays from mouse models, also identified more than 1,300 functional groups, including signaling and transcription pathways, which may also play an important role in establishing a capacity for a "high level of alcohol consumption."

18 Apr 2006

Important new global mechanism for gene repression

Most of the time in most cells of the body, the great majority of genes are silenced, locked away within the compacted but orderly material that makes up chromosomes.

18 Apr 2006

A genomic signature of 254 genes predicting clinical outcome in Primary Cutaneous Melanoma identified

EORTC Melanoma Group researchers have identified a genomic signature predicting clinical outcome in Primary Cutaneous Melanoma, after patients having undergone standard treatment.

6 Apr 2006

Divergent behavioral roles of angiotensin receptor intracellular signaling cascades

Researchers at the University at Buffalo and the University of Pennsylvania were the first to demonstrate that two intracellular events, both stimulated by the same cell receptor, can provoke different behaviors in mammals.

23 Mar 2006

Crucial breakthrough in pectin biosynthesis

Most people know pectin as a common household gelling agent in making jams and jellies, but its uses are vast. It has anticancer properties, for instance, and may have a role in important biological functions including plant growth and development and defense against disease.

22 Mar 2006

The role of evolutionary genomics in the development of autism

Scientists at the London School of Economics, UK and Simon Fraser University, Canada have described the first hypothesis grounded in evolutionary genomics explaining the development of autism.

21 Mar 2006

A putative RNA-interference-based immune system in prokaryotes

Researchers have used computational methods to predict what could be a prokaryotic RNA-silencing mechanism similar to the eukaryotic RNA- interference system.

20 Mar 2006

New understanding of the critical molecular factors that permit viruses to jump from one species to another

Researchers studying strains of a lethal canine virus and a related human virus have determined why the canine virus was able to spread so quickly from cats to dogs, and then from sick dogs to healthy dogs.

19 Mar 2006

NHGRI announces comprehensive strategy to identify structural variation in human genome

The National Human Genome Research Institute (NHGRI), one of the National Institutes of Health (NIH), has announced its latest round of sequencing targets, with an emphasis on enhancing the understanding of how human genes function and how genomic differences between individuals influence the risk of health and disease.

19 Mar 2006

Discovery in yeast opens door to new source of information on DNA damage, repair, and cancer

The discovery in yeast cells of a genetic network that guards against lethal DNA damage is a first step in the creation of a database of disease-causing combinations of mutated human genes, according to researchers at The Johns Hopkins University School of Medicine led by Jef. D. Boeke, Ph.D.

15 Mar 2006

A map of recent positive selection in the human genome

By scanning the entire human genome in search of genetic variations that may signal recent evolution, University of Chicago researchers found more than 700 genetic variants that may be targets of recent natural positive selection during the past 10,000 years of human evolution.

13 Mar 2006

University of Michigan researchers target stubborn gram-negative bacteria

Ronald Woodard's team set out looking for a way to kill a stubborn type of bacteria and they succeeded - but not in the way he expected.

9 Mar 2006

New genome-wide map of miRNA-MRNA interactions

Researchers at New York University's Center for Comparative Functional Genomics and the University of California, Berkeley have used computational analyses to predict a genome-wide map of microRNA (miRNA) targets in the animal model organism, Caenorhabditis elegans (C. elegans).

9 Mar 2006

Removing a gene involved in repairing damaged DNA causes metabolic syndrome

Removing a gene involved in repairing damaged DNA causes mice to develop the metabolic syndrome, researchers at Oregon Health & Science University have discovered.

21 Feb 2006

Oddly shaped DNA can cause DNA breaks in mammalian cells

When otherwise normal DNA adopts an unusual shape called Z-DNA, it can lead to the kind of genetic instability associated with cancers such as leukemia and lymphoma, according to a study by researchers at The University of Texas M. D. Anderson Cancer Center.

21 Feb 2006

Scientists put ehrlichiosis under the genomic spotlight

Ehrlichiosis is no star of science. This emerging disease has an awkward name, vague flu-like symptoms, and a nasty habit of being caused by bacteria that live inside ticks and flatworms.

17 Feb 2006

Inactivating Rad9 protien could make cancer cells easier to kill with ionizing radiation

The researchers found that Rad9, previously considered a "watchman" that checks for DNA damage, is actually a "repairman" that fixes dangerous breaks in the DNA double helix. They found Rad9 is especially active in telomeres, the protective ends of chromosomes.

17 Feb 2006

Genome data may contain small but significant errors

Since the genome sequence of the bacterial pathogen Haemophilus influenzae was published in 1995, the genetic code of many other large, complex, medically, and commercially significant organisms including humans has also been elucidated

17 Feb 2006

Advancing knowledge of diet-gene interactions

Josi Ordovas, PhD, director of the Nutrition and Genomics Laboratory at the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University joined more than eighty other leading researchers in the fields of nutrition and genetics to co-author a report outlining their strategy for maximizing the impact of nutrigenomics research on global poverty and health.

16 Feb 2006