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Novel fusion inhibitor blocks SARS-CoV-2 spike-mediated cell-cell fusion

Researchers constructed a novel fusion inhibitor−based recombinant protein, referred to as 5−Helix, to block SARS-CoV-2 spike-mediated cell-cell fusion.

17 Mar 2022

Study suggests single nucleotide polymorphism in interferon receptor impacts COVID-19 outcomes

Researchers reported the association of a single nucleotide polymorphism rs9984273 in the interferon-alpha/beta receptor gene with outcomes of acute respiratory distress syndrome and COVID-19.

17 Mar 2022

SLU physician-scientist receives NIH funding for Short Bowel Syndrome research

A Saint Louis University School of Medicine scientist and SLUCare physician has received funding from the National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health (NIH) to study Short Bowel Syndrome (SBS).

16 Mar 2022

Toxin-producing yeast strains may damage the gut of patients with inflammatory bowel disease

Individual Candida albicans yeast strains in the human gut are as different from each other as the humans that carry them, and some C. albicans strains may damage the gut of patients with inflammatory bowel disease (IBD), according to a new study from researchers at Weill Cornell Medicine.

16 Mar 2022

Tracking the mutating coronavirus variants

Viruses continuously and naturally evolve. To track coronavirus variants, we need to think like Darwin.

16 Mar 2022

Multisystem inflammatory syndrome as a late complication in COVID-19 infected children

Researchers determined the immune signature of the multisystem inflammatory syndrome in children among hospitalized children diagnosed with SARS‐CoV‐2 infection.

16 Mar 2022

Sneaking large drug-carrying biological molecules into cells using a novel drug delivery system

Scientists from Nanyang Technological University, Singapore have developed a novel method of delivering drugs into human cells using large biological molecules, by first encasing them in a protein-based microdroplet.

16 Mar 2022

Epigenetic changes could be a biomarker for early detection of type 1 diabetes

Children who develop type 1 diabetes show epigenetic changes in the cells of their immune system already before the antibodies of the disease are detected in their blood.

16 Mar 2022

Study reveals how to identify and avoid risks related to mitochondrial therapeutic interventions

Research carried out at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) has demonstrated that mixing mitochondrial DNAs (mtDNAs) of different origins can have damaging effects over the medium and long term.

16 Mar 2022

Roche launched world's first COVID-19 PCR test two years ago

In the two years since it launched the world's first commercially available COVID-19 PCR test, Roche Diagnostics UK and Ireland has distributed ten million tests from its base in West Sussex.

From Roche Sequencing and Life Science 16 Mar 2022

SARS-CoV-2 infection model generated from human tonsil epithelial organoids

Researchers evaluate the feasibility of tonsil epithelial cell-derived organoids as an ex vivo model for studying SARS-CoV-2 infection.

15 Mar 2022

High blood pressure genes improve outcomes after congenital heart defect repair surgery

Children with a genetic makeup that predicts high blood pressure as adults are more likely to survive congenital heart defect repair surgery, according to a new study published in Circulation Research.

15 Mar 2022

Synthetic viral vector and surgical approach enable efficient gene transfer into the inner ear of primates

A synthetic viral vector and a novel surgical approach developed at Mass Eye and Ear has enabled efficient gene transfer into the inner ear of nonhuman primates, a research team working towards the development of effective treatments for hearing loss and vestibular disorders has reported.

15 Mar 2022

Bacteria change their morphology when acquiring drug resistance, study reveals

If you've been hitting the gym and getting results, you know it's time to strut your stuff; and it turns out bacteria feel the same way.

15 Mar 2022

Study takes a new approach to looking at de novo genetic variants in autism

About 1 in 44 children in the U.S. are diagnosed with autism spectrum disorder (ASD) by the age of 8, according to the 2018 Centers for Disease Control and Prevention surveillance. How a child's DNA contributes to the development of ASD has been more of a mystery.

15 Mar 2022

Cell fusion could be a potential therapeutic strategy to treat retinal damage

Fusing human retinal cells with adult stem cells could be a potential therapeutic strategy to treat retinal damage and visual impairment, according to the findings of a new study published in the journal eBioMedicine.

15 Mar 2022

New way to deliver potential HIV vaccine using mRNA technology

Using mRNA technology like that in the COVID-19 vaccines, researchers have demonstrated a successful way to deliver a potential HIV vaccine, researchers at Duke Human Vaccine Institute report.

15 Mar 2022

Study shows genetic link between endometriosis and ovarian cancer subtypes

University of Queensland researchers have demonstrated a genetic link between endometriosis and ovarian cancer subtypes enabling them to identify potential drug targets for therapy and increasing the understanding of both diseases.

15 Mar 2022

SARS-CoV-2 in diabetes pathogenesis

Researchers reviewed the causes of diabetes mellitus, focusing on respiratory viruses, including influenza virus and SARS-CoV-2.

15 Mar 2022

Using mRNA to introduce gene editor into human muscle stem cells

Mutations that lead to muscle atrophy can be repaired with the gene editor CRISPR-Cas9. A team led by ECRC researcher Helena Escobar has now introduced the tool into human muscle stem cells for the first time using mRNA, thus discovering a method suitable for therapeutic applications.

14 Mar 2022