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"Zombie" viral fragments trigger inflammation to cause serious COVID-19 outcomes

There are many lingering mysteries from the COVID-19 pandemic. For instance, why does SARS-CoV-2, the virus behind the disease, cause severe symptoms in some patients, while many other coronaviruses don't? And what causes strange symptoms to persist even after the infection has been cleared from a person's system?

30 Jan 2024

Improving mitochondrial metabolism could be a potential therapeutic target for Alzheimer's

Nerve cells in the brain demand an enormous amount of energy to survive and maintain their connections for communicating with other nerve cells.

30 Jan 2024

New drug kills tumor cells by triggering a deadly calcium storm

Calcium ions are essential for cells, but can be toxic in higher concentrations. A team of researchers has now designed and prepared a combination drug that kills tumor cells by modulating the calcium influx into the cell.

30 Jan 2024

Bio-Techne’s Advanced Cell Diagnostics (ACD) sets new standard in spatial biology with protease-free RNAscope multiomics

Bio-Techne Corporation (NASDAQ: TECH) today announced that Advanced Cell Diagnostics (ACD), a Bio-Techne spatial biology brand, has set a new standard with the development of a next-generation, protease-free RNAscope spatial multiomics workflow.

From Bio-Techne 30 Jan 2024

Oncofetal ecosystems linked to recurrence and immunotherapy response in liver cancer

A team of clinician-scientists and researchers from the National Cancer Centre Singapore (NCCS), Agency for Science, Technology and Research (A*STAR), the Harry Perkins Institute of Medical Research and global research partners, has found a causal link between the presence of oncofetal ecosystems (re-emergence of fetal programme/features driven by the tumor) in the primary liver cancer hepatocellular carcinoma (HCC) and cancer recurrence and response to immunotherapy.

29 Jan 2024

Hydroxyurea treatment can greatly benefit children with sickle cell anemia, study reveals

Clinical research led by Indiana University School of Medicine investigators and their collaborators in Uganda has revealed that hydroxyurea significantly reduces infections in children with sickle cell anemia.

29 Jan 2024

Scientists reveal direct link between mitochondrial DNA mutations and cancer treatment response

Cancer Research UK-funded scientists have made an unusual discovery that could help to identify patients who are up to two and a half times more likely to respond to currently available cancer drugs.

29 Jan 2024

Gene variant linked to increased miscarriage risk through disrupted chromosome pairing

Scientists at deCODE genetics, a subsidiary of Amgen and their collaborators from Iceland, Denmark and USA published a study today in Nature Structural and Molecular Biology titled "Variant in the synaptonemal complex protein SYCE2 associates with pregnancy loss through effects on recombination".

29 Jan 2024

Blood chip could offer early insights into cancer treatment effectiveness

Using a chip to process blood samples, doctors can monitor the amount of cancer cells in a patient’s blood to determine how well a treatment is working by the fourth week, according to a new University of Michigan study.

29 Jan 2024

Subcutaneous nivolumab revolutionizes renal cell carcinoma care with faster, easier treatment

Subcutaneous injection of the immunotherapy nivolumab (brand name Opdivo) is noninferior to intravenous delivery and dramatically reduces treatment time in patients with renal cell carcinoma, as seen in the results of a large phase 3 clinical trial reported today at the 2024 American Society of Clinical Oncology (ASCO) Genitourinary Cancers Symposium in San Francisco, California.

29 Jan 2024

Study identifies risk factors for deadly blood clots after lung cancer surgery

In patients who undergo pulmonary resection for lung cancer, a major potential postoperative complication is venous thromboembolism (VTE) - a condition that develops when a blood clot forms in a vein - which can lead to part of the clot breaking off and lodging in the lung, resulting in a pulmonary embolism (PE).

29 Jan 2024

Asimov launches LV Edge Packaging System to optimize lentivirus production

New off-the-shelf system reduces the cost and risk of lentiviral (LV) production for cell and gene therapy developers.

From Asimov 29 Jan 2024

Dr. Chao Ma: Pioneering 'Leukemia-on-a-Chip' for CAR T Cell Therapy at SLAS 2024

NewsMedical speaks with Chao Ma, Ph.D. a Research Assistant Professor at New York University Tandon School of Engineering, ahead of his presentation at SLAS 2024.

From Society for Laboratory Automation and Screening (SLAS) 29 Jan 2024

Scientists discover key pathway linking brain's habit center and motor learning region

Researchers explored how the cerebellum directly affects dopamine release in the substantia nigra compacta (SNc).

29 Jan 2024

How does the nasal cavity's immune system combat SARS-CoV-2?

Researchers discovered that CD4+ and CD8+ T cells play a crucial role in clearing COVID-19 infection in the nasal cavity but have limited impact on lung infections, with implications for understanding and treating the virus.

28 Jan 2024

Revolutionary CAR T-cell therapy shows promise in reversing age-related metabolic dysfunction

study evaluates senolytic CAR T-cell therapy targeting uPAR-positive cells in aged mice, showing its effectiveness in mitigating age-related metabolic dysfunction and offering a potential long-lasting treatment for aging-associated conditions.

28 Jan 2024

New brain implant records neuron activity for months

Recording the activity of large populations of single neurons in the brain over long periods of time is crucial to further our understanding of neural circuits, to enable novel medical device-based therapies and, in the future, for brain–computer interfaces requiring high-resolution electrophysiological information.

27 Jan 2024

Exploring pharmacological, non-pharmacological, and stem cell therapies for treatment of autism spectrum disorders

A research study, led by Maurizio Battino and Francesca Giampieri, with a group of researchers from the Universidad Europea del Atlántico (European University of the Atlantic, UNEATLANTICO), published in the journal "Pharmacological Research", studies various pharmacological, non-pharmacological, and stem cell therapies for the treatment of autism spectrum disorders.

27 Jan 2024

Gene activity plays key role in immune cell production, study shows

As people age or become ill, their immune systems can become exhausted and less capable of fighting off viruses such as the flu or COVID-19.

27 Jan 2024

Prior exposure to common cold coronaviruses can train T cells to fight SARS-CoV-2

Scientists at La Jolla Institute for Immunology (LJI) have found direct evidence that exposure to common cold coronaviruses can train T cells to fight SARS-CoV-2. In fact, prior exposure to a common cold coronavirus appears to partially protect mice from lung damage during a subsequent SARS-CoV-2 infection.

27 Jan 2024

Cell News and Research

"Zombie" viral fragments trigger inflammation to cause serious COVID-19 outcomes

Improving mitochondrial metabolism could be a potential therapeutic target for Alzheimer's

New drug kills tumor cells by triggering a deadly calcium storm

Bio-Techne’s Advanced Cell Diagnostics (ACD) sets new standard in spatial biology with protease-free RNAscope multiomics

Oncofetal ecosystems linked to recurrence and immunotherapy response in liver cancer

Hydroxyurea treatment can greatly benefit children with sickle cell anemia, study reveals

Scientists reveal direct link between mitochondrial DNA mutations and cancer treatment response

Gene variant linked to increased miscarriage risk through disrupted chromosome pairing

Blood chip could offer early insights into cancer treatment effectiveness

Subcutaneous nivolumab revolutionizes renal cell carcinoma care with faster, easier treatment

Study identifies risk factors for deadly blood clots after lung cancer surgery

Asimov launches LV Edge Packaging System to optimize lentivirus production

Dr. Chao Ma: Pioneering 'Leukemia-on-a-Chip' for CAR T Cell Therapy at SLAS 2024

Scientists discover key pathway linking brain's habit center and motor learning region

How does the nasal cavity's immune system combat SARS-CoV-2?

Revolutionary CAR T-cell therapy shows promise in reversing age-related metabolic dysfunction

New brain implant records neuron activity for months

Exploring pharmacological, non-pharmacological, and stem cell therapies for treatment of autism spectrum disorders

Gene activity plays key role in immune cell production, study shows

Prior exposure to common cold coronaviruses can train T cells to fight SARS-CoV-2

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