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CAR T therapy can lead to long-lasting remissions in patients with r/r diffuse large B-cell lymphoma

In an update to a global clinical trial stretching from Philadelphia to four continents, the chimeric antigen receptor (CAR) T cell therapy Kymriah (tisagenlecleucel, formerly CTL019) led to long-lasting remissions in patients with relapsed/refractory (r/r) diffuse large B-cell lymphoma (DLBCL).

3 Dec 2018

Scientists alleviate schizophrenic symptoms in mice

Despite extensive research efforts, schizophrenia remains one of the least understood brain disorders. One promising area of research is in receptors on the surfaces of brain cells that help sense growth factors.

30 Nov 2018

New strategy for developing cell replacement therapies to combat type 1 diabetes

Scientists have discovered the signals that determine the fate of immature cells in the pancreas. The research shows that they are very mobile and that their destiny is strongly influenced by their immediate environment.

29 Nov 2018

Lipid that helps keep skin cell turnover on track may aid in psoriasis

A lipid that helps keep skin cell turnover on track may help restore healthy turnover in psoriasis, investigators say.

28 Nov 2018

Study provides insights into the mechanism of Gip1 interaction with G proteins

Heterotrimeric G proteins are important in G protein-coupled receptor signaling, which plays many roles in the detection of various environmental stimuli, including hormones, neurotransmitters, light, smells, and chemical signals.

27 Nov 2018

Using molecular targeting approach to kill melanoma cells

In 1960, scientists described the "Philadelphia chromosome" that causes chronic myeloid leukemia, and in 2001 the Food and Drug Administration approved the drug imatinib to disable the action of this cancer-causing genetic change.

27 Nov 2018

FDA grants accelerated approval to oncology drug for treatment of key genetic driver of cancer

The U.S. Food and Drug Administration today granted accelerated approval to Vitrakvi (larotrectinib), a treatment for adult and pediatric patients whose cancers have a specific genetic feature (biomarker).

27 Nov 2018

A love of coffee and tea is mostly genetic

The morning coffee or tea can perk one up for the day, however, for some of us these beverages are too bitter. Researchers have now found that the bitter taste experienced is all down to genes. The new study titled, “Understanding the role of bitter taste perception in coffee, tea and alcohol consumption through Mendelian randomization,” was published in the latest issue of the journal Nature Scientific Reports.

25 Nov 2018

Researchers discover new mitochondrial mechanism

Researchers at the University of Freiburg have discovered a mechanism within cells that enables proteins to be delivered into the mitochondria.

22 Nov 2018

Discovery of new gene could lead to better understanding of human susceptibility to chemicals

The discovery of a new gene in zebrafish could lead to a better understanding of how exposure to chemicals leads to disease in humans, according to a new Oregon State University study.

22 Nov 2018

Scientists identify key protein involved in Hantavirus Pulmonary Syndrome

A global team of investigators has identified a key protein involved in Hantavirus Pulmonary Syndrome, a serious and sometimes fatal respiratory disease, according to research published today in the journal Nature.

22 Nov 2018

Researchers aim to protect humans, mammals from deadly effects of African sleeping sickness

A team of Clemson University researchers wants to protect humans and other mammals from the debilitating and even deadly effects of African sleeping sickness.

21 Nov 2018

Researchers awarded $7 million funding in Pancreatic Cancer Collective’s 'New Therapies Challenge'

The Pancreatic Cancer Collective, the strategic partnership of the Lustgarten Foundation and Stand Up To Cancer, has awarded a total of $7 million in first-round "New Therapies Challenge" grants to seven teams of top cancer researchers to explore new pancreatic cancer treatments, the American Association for Cancer Research, the Scientific Partner of SU2C, announced today.

21 Nov 2018

Stand Up to Cancer supports potential approach to more efficiently target pancreatic cancer

Research on a new way of deploying the immune system against pancreatic cancer, an exceptionally lethal cancer that has so far resisted new immunotherapies, will receive $1 million in initial funding from Stand Up to Cancer.

21 Nov 2018

Gut protein mutations protect against spikes in blood glucose levels

Why is it that, despite consuming the same number of calories, sodium and sugar, some people face little risk of diabetes or obesity while others are at higher risk? A new study by investigators at Brigham and Women's Hospital has uncovered mutations in a gene that appear to help drive this difference.

21 Nov 2018

Abramson Cancer Center becomes the 28th member institution of National Comprehensive Cancer Network

The Abramson Cancer Center (ACC) at the University of Pennsylvania announced today that it is joining the National Comprehensive Cancer Network (NCCN) as its 28th member institution.

20 Nov 2018

Vitamin D critical to early development of vertebrates, study suggests

New research from Portland State University finds vitamin D, or a lack thereof can trigger or suspend embryonic development in a species of fish. The study also provides evidence suggesting the vitamin is critical to the early development of vertebrates generally.

20 Nov 2018

Scientists identify novel target for neuron regeneration, functional recovery in spinal cord injury

Restoring the ability to walk following spinal cord injury requires neurons in the brain to reestablish communication pathways with neurons in the spinal cord.

20 Nov 2018

Researchers have trained a computer to analyze breast cancer images and classify tumors

Using technology similar to the type that powers facial and speech recognition on a smartphone, researchers at the University of North Carolina Lineberger Comprehensive Cancer Center have trained a computer to analyze breast cancer images and then classify the tumors with high accuracy.

19 Nov 2018

New glucose binding molecule could be key to better metabolic control for diabetics

Scientists from the University of Bristol have designed a new synthetic glucose binding molecule platform that brings us one step closer to the development of the world's first glucose-responsive insulin which, say researchers, will transform the treatment of diabetes.

19 Nov 2018

Receptor News and Research

CAR T therapy can lead to long-lasting remissions in patients with r/r diffuse large B-cell lymphoma

Scientists alleviate schizophrenic symptoms in mice

New strategy for developing cell replacement therapies to combat type 1 diabetes

Lipid that helps keep skin cell turnover on track may aid in psoriasis

Study provides insights into the mechanism of Gip1 interaction with G proteins

Using molecular targeting approach to kill melanoma cells

FDA grants accelerated approval to oncology drug for treatment of key genetic driver of cancer

A love of coffee and tea is mostly genetic

Researchers discover new mitochondrial mechanism

Discovery of new gene could lead to better understanding of human susceptibility to chemicals

Scientists identify key protein involved in Hantavirus Pulmonary Syndrome

Researchers aim to protect humans, mammals from deadly effects of African sleeping sickness

Researchers awarded $7 million funding in Pancreatic Cancer Collective’s 'New Therapies Challenge'

Stand Up to Cancer supports potential approach to more efficiently target pancreatic cancer

Gut protein mutations protect against spikes in blood glucose levels

Abramson Cancer Center becomes the 28th member institution of National Comprehensive Cancer Network

Vitamin D critical to early development of vertebrates, study suggests

Scientists identify novel target for neuron regeneration, functional recovery in spinal cord injury

Researchers have trained a computer to analyze breast cancer images and classify tumors

New glucose binding molecule could be key to better metabolic control for diabetics

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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