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Report identifies early childhood conditions that lead to adult health disparities

The origins of many adult diseases can be traced to early negative experiences associated with social class and other markers of disadvantage.

2 Jun 2009

Discovery of enzyme involved in inflammatory bowel disease

Researchers at Penn State College of Medicine, working with biochemists, geneticists and clinicians at the University of Bern, Switzerland and in the United Kingdom, have discovered an enzyme that has a key role in inflammatory bowel disease (IBD).

2 Jun 2009

Greater understanding on leptin's role in brain neurocircuitry

In investigating the complex neurocircuitry behind weight gain and glucose control, scientists have known that the hormone leptin plays a key role in the process. But within the myriad twists and turns of the brain's intricate landscape, the exact pathways that the hormone travels to exert its influence have remained a mystery.

2 Jun 2009

Benefit to women not enough to sway men to get HPV vaccine

Informing men that a new vaccine to prevent human papillomavirus (HPV) would also help protect their female partners against developing cervical cancer from the sexually transmitted infection did not increase their interest in getting the vaccine, according to a new Florida State University study.

2 Jun 2009

Study shows people with mental health problems receive inadequate medical care

New research led by the University of Leicester and published this week in the British Journal of Psychiatry reveals that people with mental health problems are receiving inferior care for their medical needs.

2 Jun 2009

Model for new generation of blood vessels challenged

In-growth and new generation of blood vessels, which must take place if a wound is to heal or a tumor is to grow, have been thought to occur through a branching and further growth of a vessel against a chemical gradient of growth factors. Now a research team at Uppsala University and its University Hospital has shown that mechanical forces are considerably more important than was previously thought.

2 Jun 2009

FDA antidepressant warnings led to unintended changes in depression diagnosis

Government warnings about suicidality among children taking antidepressants appear to be associated with unintended and persistent changes in the diagnosis and treatment of depression in children and adults, according to a report in the June issue of Archives of General Psychiatry.

1 Jun 2009

Language use decreases in young children and caregivers when TV is on

In a new study, young children and their adult caregivers uttered fewer vocalizations, used fewer words and engaged in fewer conversations when in the presence of audible television.

1 Jun 2009

Study to evaluate ‘Active Hexose Correlated Compound’ and the swine flu virus

A study evaluating the effect of AHCC (Active Hexose Correlated Compound) on supporting the immune system in response to the swine flu virus will be conducted at the Southern China Agricultural University, one of the few research centers in China that have been approved to conduct studies on highly infectious diseases such as the swine flu. This controlled study will examine the effects of AHCC when supplemented to a group of mice infected with the virus.

1 Jun 2009

Calculating the return on investment of mobile healthcare

Every $1 invested in mobile healthcare for the medically disenfranchised saves $36 in combined emergency department costs avoided and value of life years saved.

1 Jun 2009

Gene that stops or suppress cancer plays a role in cancer stem cells

A gene well known to stop or suppress cancer plays a role in cancer stem cells, according to a new study from the University of Michigan Comprehensive Cancer Center. The researchers found that several pathways linked to the gene, called PTEN, also affected the growth of breast cancer stem cells.

1 Jun 2009

Taking a break from hormones doesn't improve mammograms

Some women take a short break from using postmenopausal hormone therapy before getting their breasts screened for cancer with mammography. They hope to lower their risk of being called back afterward for unnecessary extra breast imaging. But taking a short break from hormones doesn't actually work for this purpose, according to the first large-scale randomized controlled trial to address the question. The READ (Radiological Evaluation and Breast Density) trial of more than 1,700 Group Health women is in the June 2, 2009 Annals of Internal Medicine.

1 Jun 2009

Pay-for-performance may benefit doctors who care for multiple health problems

Physicians who treat patients with multiple health problems will fare well under pay-for-performance, which bases physician reimbursement on the quality of care provided, said researchers at Baylor College of Medicine and the Michael E. DeBakey Veterans Affairs Medical Center in Houston in a report in the current issue of the journal Circulation.

1 Jun 2009

Discovery of gene that regulates tumors in neuroblastoma

Virginia Commonwealth University researchers have identified a gene that may play a key role in regulating tumor progression in neuroblastoma, a form of cancer usually found in young children. Scientists hope the finding could lead to an effective therapy to inhibit the expression of this gene.

1 Jun 2009

Rapamycin epilepsy-prevention effect may be widely applicable

A drug with potential to prevent epilepsy caused by a genetic condition may also help prevent more common forms of epilepsy caused by brain injury, according to researchers at Washington University School of Medicine in St. Louis.

1 Jun 2009

Findings in epilepsy gene in animals may guide treatment directions for infants

Researchers studying a difficult-to-treat form of childhood epilepsy called infantile spasms have developed a line of mice that experiences seizures with features closely resembling those occurring in patients with infantile seizures. These genetically engineered mice provide a new opportunity for scientists to test treatments that may benefit children.

1 Jun 2009

Glioblastoma may originate in neural stem cells

University of Michigan scientists have found that a deficiency in a key tumor suppressor gene in the brain leads to the most common type of adult brain cancer. The study, conducted in mice that mimic human cancer, points the way to more effective future treatments and a way to screen for the disease early.

1 Jun 2009

17 million U.S. children live over an hour away from a pediatric trauma center

More than 17 million U.S. children live more than an hour away by ground or air transportation from a life-saving pediatric trauma center, according to a new study by researchers at The Children's Hospital of Philadelphia and the University of Pennsylvania. The creation of a national inventory of pediatric trauma centers may help to identify the locations of gaps and greatly improve access to care for U.S. children, the authors said.

1 Jun 2009

Lower levels of PHD2 protein influence tumor growth in mice

Tumors need a healthy supply of blood to grow and spread. Researchers at the Stanford University School of Medicine have identified a molecule that regulates blood vessel growth that is often found at less-than-normal levels in human tumors. Blocking the expression of the molecule, called PHD2, allows human cancer cells to grow more quickly when implanted into mice and increases the number of blood vessels feeding the tumor.

1 Jun 2009

Old drug Auranofin may lead to new antibiotics

A mineral found at health food stores could be the key to developing a new line of antibiotics for bacteria that commonly cause diarrhea, tooth decay and, in some severe cases, death.

1 Jun 2009