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Receptor structure could be key to developing new osteoporosis drugs

Researchers at the University of Zurich have determined the three-dimensional structure of a receptor that controls the release of calcium from bones. The receptor is now one of the main candidates for developing new drugs to treat osteoporosis.

19 Nov 2018

Researchers find crucial inhibitory role for signal peptide in GluK1 trafficking

Glutamate is the major excitatory neurotransmitter in the brain, and the postsynaptic expression level of glutamate receptors is a critical factor in determining the efficiency of information transmission and the activity of the neuronal network.

19 Nov 2018

Researchers develop novel mouse model to study immunomodulatory therapies

Because mice do not respond to immunomodulatory drugs, preclinical therapeutic and safety studies of the effects of IMiDs have not been possible in existing types of mice.

19 Nov 2018

Protein which plays role in sensing cell damage serves as new target to treat pulmonary hypertension

A protein with a role in sensing cell damage and viral infections is a new target for the treatment of pulmonary hypertension, or increased blood pressure in the lungs, according to research led by Virginia Commonwealth University and the University of Sheffield in the United Kingdom.

16 Nov 2018

Inhibition of prostaglandin E2 enhances ability to combat infectious colitis

The treatment of intestinal infections caused by some strains of the bacterium Escherichia coli, present in unsanitized or contaminated foods, may have a new ally.

15 Nov 2018

New diabetes drugs linked to increased risk of lower-limb amputation and ketoacidosis

The use of a new class of drugs in the treatment of type 2 diabetes, so called SGLT2 inhibitors, are linked to a twofold increased risk for lower-limb amputation as well as diabetic ketoacidosis, a serious diabetes complication.

14 Nov 2018

Two genomic tests help identify most effective treatment for breast cancer patients

New results from a long-running trial to identify which new drugs or combinations of drugs are most effective in which types of breast cancer, show that two genomic tests are bringing the era of truly personalized medicine ever nearer.

14 Nov 2018

Study defines biomarker in response to treatment of castration-resistant prostate cancer

The most aggressive type of prostate cancer, castration-resistant prostate cancer, can be treated with two different therapies: taxanes or hormone treatment. Until this day there are no comparative studies between the two and the decision on which treatment to use is done empirically and based on the patient's preferences.

14 Nov 2018

New anti-HER2 drug shows promising anti-tumor activity in gullet, stomach and bowel cancers

An antibody that binds simultaneously to two distinct regions of the HER2 receptor to block the growth of cancer cells has shown promising signs of anti-tumor activity in a number of cancers including those of the gullet (esophagus), stomach and bowel.

14 Nov 2018

Breakthrough research could lead to a new wave of cancer-fighting antibodies

Scientists at the University of Southampton have developed a new antibody that could hold the key to unlocking cancer's defense against the body's immune system.

13 Nov 2018

Immunity connects gut microbiota and age-related pathologies

EPFL scientists have discovered how a dysfunction in the immune system can cause an overload of a gut bacterium. The bacterium produces excess lactic acid, which in turn triggers the production of reactive oxygen species that cause damage to cells and many age-related pathologies.

13 Nov 2018

Study uncovers link between gut disruption and aging

A new study has shed light on how the disruption of commensal bacteria within the gut can affect the immune system and lead to age-related pathologies.

13 Nov 2018

Angiotensin receptor blockers improve sodium excretion in blacks

Drugs that inhibit a hormone that constricts blood vessels also help improve sodium excretion in blacks who hold onto too much sodium in the face of stress, investigators report.

13 Nov 2018

Breakthrough research reveals how deadly pneumococcus avoids immune defenses

Scientists at the University of Liverpool have discovered a new and important function of a toxin produced by disease-causing bacteria that could have significant implications for future vaccine design.

12 Nov 2018

Growth and spread of deadly eye tumor suppressed in cells, animals

By comparing genetic sequences in the eye tumors of children whose cancers spread with tumors that didn't spread, Johns Hopkins Medicine researchers report new evidence that a domino effect in cells is responsible for the cancer spreading.

12 Nov 2018

Study shows how pneumococci challenge the immune system

Pneumococci are the most common cause of respiratory tract infections, such as otitis and sinusitis, as well as of severe infections like pneumonia and meningitis.

12 Nov 2018

Scientists uncover hidden estrogen receptors in epithelial breast cells

Estrogens are hormones that play central roles in the development and the physiology of the breast, but also are involved in breast cancer. Like all hormones, estrogens exert their biological effects by binding to dedicated receptors in the target cell.

9 Nov 2018

New study sheds light on how CAR T cell therapy works

Cancer remains the second-leading cause of death in the United States. This year, an estimated 1.7 million new cases will be diagnosed, with nearly 610,000 people expected to die from the disease, according to the National Cancer Institute.

8 Nov 2018

New research to understand fundamental role of ubiquitin in cell death or survival

An effective regulation of programmed cell death is crucial for the correct development of embryos, a working innate immune system, and the prevention of cancer. How cells control the switch between cell survival and death, and which signaling pathways are involved, remain unclear.

8 Nov 2018

Nasal delivery of leptin hormone may help ease breathing problems during sleep

Experimenting with mice, Johns Hopkins Medicine researchers have added to evidence that a hormone best known for helping regulate hunger and body weight might also ease breathing problems experienced during sleep more effectively when given through the nose.

7 Nov 2018