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DNA discovery could help point towards causes of developmental condition in children

New insights into how our cells store and manage DNA during cell division could help point towards the causes of a rare developmental condition.

21 Sep 2017

Study identifies slowly proliferating and highly invasive melanoma cells

A study conducted at The Wistar Institute has led to the identification of a slowly proliferating and highly invasive melanoma cell subpopulation, characterized by production of a protein associated with invasive behavior. The research was published in the journal Oncogene.

21 Sep 2017

Researchers discover ‘recycled’ genes in mammalian genome

One often hears about the multitude of genes we have in common with chimps, birds or other living creatures, but such comparisons are sometimes misleading. The shared percentage usually refers only to genes that encode instructions for making proteins -- while overlooking regulatory genes, which nonetheless make up a large part of the genome.

18 Sep 2017

Penn study provides insight into how cells maintain identity during replication

Prior to cell division, chromosomes are seemingly a jumbled mess. During cell division, parent cell chromosomes and their duplicates sort themselves out by condensing, becoming thousands of times more compact than at any other time.

15 Sep 2017

Researchers discover major mechanism in development of liver cancer

Liver cancer is the second-leading cause of cancer-related death and represents the fastest rising cancer worldwide. In most cases, the tumor develops in patients with chronic liver disease.

11 Sep 2017

Penn researchers find abnormally shortened telomeres in young DMD patients’ muscle stem cells

Researchers from the Perelman School of Medicine at the University of Pennsylvania have made a discovery about muscular dystrophy disorders that suggest new possibilities for treatment.

7 Sep 2017

Research provides new insights into secret life of bacteria

Bacterial infections are the number one cause of death in hospital patients in the United States, and antibiotic-resistant bacteria are on the rise, causing tens of thousands of deaths every year.

6 Sep 2017

Antibiotics may kill bacteria differently in vitro vs in vivo

Understanding exactly how antibiotics work (or don’t work) is crucial for developing alternative treatment strategies, not only to target new “superbugs,” but also to make existing drugs more effective against their targets.

5 Sep 2017

Scientists show how receptors for drugs act inside cells

G protein-coupled receptors are the key target of a large number of drugs. Würzburg scientists have now been able to show more precisely how these receptors act in the cell interior.

5 Sep 2017

St. Jude creates world’s largest collection of pediatric solid tumor samples

In an effort to improve outcomes for patients with some of the deadliest childhood cancers, St. Jude Children's Research Hospital scientists have created the world's largest collection of pediatric solid tumor samples, drug-sensitivity data and related information and have made the resource available at no charge to the global scientific community.

31 Aug 2017

Study sheds new light on gene fusion in bladder and brain cancer

A study by the University of Warwick sheds new light on gene fusion in bladder and brain cancer.

30 Aug 2017

Study: People with shorter LTL have more benefits on cognition following lifestyle intervention

Is telomere length associated with the cognitive response to a lifestyle intervention? Supporting evidence from the FINGER trial.

29 Aug 2017

Immune booster could improve effectiveness of vaccines and cancer immunotherapy

Vaccines and cancer immunotherapies do essentially the same thing: They boost a person's immune system, better enabling it to fight an offender, be it microbe or malignancy.

29 Aug 2017

Study tests therapeutic effect of conventional and new cancer drug combinations

Cancer is one of the major causes of death worldwide affecting 8.2 million of people per year, and in the US, the number of new cases will achieve 1.6 million in 2017. The global impact of this disease costs a trillion of dollars, which makes critical the development of new drugs and treatment against it.

28 Aug 2017

Bacterial infections may trigger dysregulation of blood formation

It has been thought that only immune cells would act as the line of defense during bacterial infection. However, recent research has revealed that hematopoietic stem cells, cells that create all other blood cells throughout an individual's lifetime, are also able to respond to the infection.

24 Aug 2017