Corticosteroid News and Research

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Corticosteroids are any steroid hormones made in the adrenal cortex (the outer part of the adrenal gland). They are also made in the laboratory. Corticosteroids have many different effects in the body, and are used to treat many different conditions. They may be used as hormone replacement, to suppress the immune system, and to treat some side effects of cancer and its treatment. Corticosteroids are also used to treat certain lymphomas and lymphoid leukemias.

Spacers versus nebulisers for treatment of acute asthma

Two treatment methods for asthma attacks - spacers and nebulizers - are equally effective in staving off hospital admissions, a new review shows. However, at least for children, spacers mean shorter stays in emergency departments.

29 May 2006

Inhaled corticosteroids can reduce breathing problems in children at high risk for asthma

Studies in older children and adults show that the most effective long-term control medicine for persistent asthma (symptoms more than two days a week or more than twice a month at night) is inhaled corticosteroids, which reduce airway swelling and help prevent asthma symptoms (e.g., asthma attacks).

10 May 2006

Corticosteroids may be linked to an increased risk for atrial fibrillation

High doses of medications known as corticosteroids may be linked to an increased risk for atrial fibrillation, a heart rhythm disorder characterized by an irregular heartbeat, according to an article in the May 8 issue of Archives of Internal Medicine.

9 May 2006

Corticosteroids do not improve survival in patients with late-stage acute respiratory distress syndrome

The study is the first multi-center randomized clinical trial to evaluate the effects of moderate doses of steroids in ARDS patients when treatment is started 7 days or more after the onset of the condition.

20 Apr 2006

Inhaled corticosteroids ease asthma symptoms

Adults and children with asthma will breathe deeper and have better control over their asthma with inhaled corticosteroids than with the medicine cromolyn, according to a new review of recent studies comparing the two treatments.

18 Apr 2006

It's a vicious circle - exposure to stress causes anxiety and depression

Experts in the United States say the results of a study with mice suggests that stress in itself may cause anxiety and depression.

18 Apr 2006

Locally injected steroids may not do much good for chronic headache pain

Locally injected steroids apparently don't enhance treatments for acute headache or migraine pain.

18 Apr 2006

Anxiogenic-like effect of chronic corticosterone in the light-dark emergence task in mice

Neuroscientists at Harvard Medical School and its affiliate McLean Hospital have shown that long-term exposure to stress hormone in mice directly results in the anxiety that often comes with depression.

18 Apr 2006

Targeting the inflamed synovium: The quest for specificity

In the April 2006 issue of Arthritis & Rheumatism, noted rheumatology specialists with Kings College London, Dr. Toby Garrood and Dr. Costantino Pitzalis offer an overview of recent breakthroughs and a preview of future directions in this critical quest for specificity.

4 Apr 2006

Targeting of angiogenic endothelial cells at sites of inflammation by Dexamethasone Phosphate-containing RGD peptide liposomes inhibits experimental arthritis

Vascular endothelial cells (VECs) form the walls of blood vessels and play a critical role in inflammation.

4 Apr 2006

Novel therapy for chronic graft-versus-host disease

A study by Dana-Farber Cancer Institute researchers offers the strongest evidence yet of the effectiveness of a novel therapy for chronic graft-versus-host disease (GVHD), a potentially life-threatening complication of donor bone marrow and stem cell transplants.

28 Mar 2006

Novel therapy for chronic graft-versus-host disease (GVHD) using Rituximab

Dana-Farber researchers found that rituximab reduced the severity of chronic graft-versus-host disease (GVHD) in 70 percent of the study participants.

27 Mar 2006

Asthma drug approved for children age four up

The U.S. Food and Drug Administration (FDA) has given approval for the use of the asthma drug Flovent HFA in children four to eleven years of age.

26 Mar 2006

A newly recognized type of immune cell may play an important role in causing asthma

...perhaps explaining why current therapies sometimes fail, report researchers from Children's Hospital Boston in the New England Journal of Medicine.

21 Mar 2006

Swedish theory suggests treatment for Avian Influenza Infection

Chemotherapy for a disorder of the immune system may - at least in theory - be effective against severe human avian influenza infection, this suggest scientists at the Karolinska Institutet.

8 Mar 2006

Study reveals most common causes of allergic contact dermatitis

A new Mayo Clinic study reveals the most common causes of allergic contact dermatitis, a skin inflammation resulting in swollen, reddened and itchy skin due to direct contact with an allergen.

7 Mar 2006

Topical therapies show promise for Psoriasis

Psoriasis, a chronic skin condition characterized by thick, red, scaly patches that itch and bleed, not only makes the activities of daily life difficult, but also can affect a person's emotional well being.

6 Mar 2006

Ginkgo biloba reduces aggressive cancer risk in animal experiments

Researchers at Georgetown University Medical Center say they now have a clearer picture of how an extract from the leaves of the Ginkgo biloba tree reduces the risk of aggressive cancer in animal experiments.

27 Feb 2006

Study associates chronic, severe inflammation with increased lymphoma risk among RA patients

An inflammatory disease of the immune system, rheumatoid arthritis (RA) is associated with increased occurrence of lymphoma--or cancers of the lymphatic system, which plays an integral role in the body's ability to fight infection.

27 Feb 2006

Hormone hydrocortisone (cortisol) supplementation improves ventilator weaning

Intensive care unit physicians can increase the success of mechanical ventilation weaning and shorten the weaning period by identifying critically ill patients who have adrenal insufficiency and treating them with the hormone hydrocortisone (cortisol).

2 Feb 2006