Clinical Trial News and Research

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Clinical scores unreliable in minor stroke and TIA

Research shows that imaging findings, rather than clinical scores, are the best means of predicting recurrent events in patients with minor stroke or transient ischaemic attack.

30 Mar 2016

Oral administration of cyclotide may improve symptoms of multiple sclerosis

MedUni Vienna has made a crucial development in the treatment of Multiple Sclerosis (MS): Together with his team and the research group led by Gernot Schabbauer, international partners from Australia, Germany and Sweden, Christian Gruber, Chief Researcher at the Center for Physiology and Pharmacology has demonstrated in an animal model that, following treatment with a specially synthesized plant peptide (cyclotide), there is no further progression of the usual clinical signs of multiple sclerosis.

29 Mar 2016

Engineered HIV vaccine protein may prevent HIV infection

Some people infected with HIV naturally produce antibodies that effectively neutralize many strains of the rapidly mutating virus, and scientists are working to develop a vaccine capable of inducing such "broadly neutralizing" antibodies that can prevent HIV infection.

28 Mar 2016

ACB could lead to quicker, safer recovery after total knee arthroplasty

Two commonly used nerve blocks during total knee arthroplasty (TKA) are the adductor canal block (ACB) and femoral nerve block (FNB). ACB appears to preserve quadriceps strength superior to FNB while maintaining adequate postoperative pain control. Improving early functional outcome could lead to a quicker and safer recovery with earlier hospital discharges.

26 Mar 2016

Wnt secretion inhibitors may reduce renal fibrosis

Renal fibrosis or the scarring of kidneys, following an injury, reduces their function and can cause kidney disease to progressively worsen.

25 Mar 2016

Incretin-based drugs do not increase risk of heart failure

Incretin-based drugs, a type of medication used to treat type 2 diabetes, do not increase the risk of being hospitalized for heart failure relative to commonly used combinations of oral anti-diabetic drugs, according to a new study published in the New England Journal of Medicine.

25 Mar 2016

SGO acting on ovarian cancer report recommendations

During the Society of Gynecologic Oncology’s 47th Annual Meeting on Women’s Cancer today, SGO convened a panel of ovarian cancer experts to discuss the recently released report by the National Academy of Medicine (NAM),

24 Mar 2016

Genetic testing in women with ovarian cancer helps determine prognosis

A study examining mutations in DNA repair genes in women with advanced ovarian cancer found that the disease remained at bay longer in women with the mutations than without, and that women having cancers with these mutations lived longer.

24 Mar 2016

Fatty acid supplement can help reduce early preterm births

Cupid was obviously a full-term baby. It's fitting then that a researcher named Valentine and her colleagues will oversee a new multicenter National Institutes of Health study to determine whether an over the counter fatty acid supplement, called DHA (Docosahexaenoic acid, an omega-3 fatty acid), can assist with reducing early preterm births.

24 Mar 2016

Blood test can predict risk of developing TB disease long before it manifests

A landmark study published this month in the leading medical journal, The Lancet, reports the discovery of a blood test that can predict whether someone is likely to develop tuberculosis (TB) disease, long before the disease manifests.

23 Mar 2016

UC San Diego Health participates in nationwide clinical study on hemophilia B gene therapy

The Hemophilia and Thrombosis Treatment Center at UC San Diego Health has joined a nationwide clinical trial testing a potential gene therapy that may one day provide a better and long-lasting treatment for people with hemophilia B.

23 Mar 2016

Integrated motivational interviewing and CBT effective for treatment of generalized anxiety disorder

Motivating willingness to change is important in treating a person with severe worry. For this, integrating motivational interviewing (MI) techniques into the commonly practised cognitive behavioral therapy (CBT) is the ideal option, a study led by a York University researcher reveals.

23 Mar 2016

Antibodies given within one day of SHIV exposure can clear the virus

Scientists at the Oregon National Primate Research Center today revealed that infant rhesus macaques treated with antibodies within 24 hours of being exposed to SHIV, a chimeric simian virus that bears the HIV envelope protein, were completely cleared of the virus.

22 Mar 2016

GEMINI LTS study: Patients with active ulcerative colitis report clinical improvements with vedolizumab treatment

Takeda Pharmaceutical Company Limited, (“Takeda”) today announced that the interim findings from the GEMINI Long-Term Safety (LTS) study were presented during the 2016 European Crohn's and Colitis Organisation (ECCO) Annual Scientific Meeting in Amsterdam, The Netherlands.

22 Mar 2016

Metabolite in gut microbiome could improve outcomes after bone marrow transplant

Could playing better defense make bone marrow transplants more successful? With this question in mind, researchers began looking at whether the trillions of little bugs and bacteria living in our gastrointestinal tract could be the key to playing defense.

22 Mar 2016

Stress management can cut risk of another heart attack by half

Patients recovering from heart attacks or other heart trouble could cut their risk of another heart incident by half if they incorporate stress management into their treatment, according to research from Duke Health.

22 Mar 2016

LEO Pharma announces scientific approval of Enstilar for treatment of people living with psoriasis in EU

LEO Pharma today announced that it received scientific approval of Enstilar (calcipotriol/betamethasone dipropionate 50 micrograms/g / 0,5 mg/g) for the treatment of psoriasis vulgaris in patients 18 years of age or older.

21 Mar 2016

Study assesses acceptability of alternative drug to prevent malaria among pregnant women in Kenya

Researchers at LSTM, working with colleagues at the Centres for Disease Control and Prevention USA, the Kenya Medical Research Institute, and from the London School of Hygiene and Tropical Medicine, have completed a study to assess the acceptability among pregnant women and health providers in Kenya of a new drug as an alternative to the standard drug used to prevent malaria in pregnancy.

21 Mar 2016

Novel compound shows promise as potential treatment for acute myeloid leukemia

A novel compound has shown promise in preclinical studies as a treatment for acute myeloid leukemia, more than doubling median days of survival even in a drug-resistant form of the disease.

21 Mar 2016

Simple TB screening and isoniazid can be effective for HIV patients at risk for TB

The number one killer of HIV patients in resource-limited areas, including parts of Africa and India, is tuberculosis (TB), underscoring the need for optimal treatments and effective strategies to address this deadly co-infection. But TB is harder to detect in HIV-infected patients and diagnostic test results take time, so many healthcare providers prescribe multi-drug TB treatments as a precaution.

20 Mar 2016

Clinical Trial News and Research

Clinical scores unreliable in minor stroke and TIA

Oral administration of cyclotide may improve symptoms of multiple sclerosis

Engineered HIV vaccine protein may prevent HIV infection

ACB could lead to quicker, safer recovery after total knee arthroplasty

Wnt secretion inhibitors may reduce renal fibrosis

Incretin-based drugs do not increase risk of heart failure

SGO acting on ovarian cancer report recommendations

Genetic testing in women with ovarian cancer helps determine prognosis

Fatty acid supplement can help reduce early preterm births

Blood test can predict risk of developing TB disease long before it manifests

UC San Diego Health participates in nationwide clinical study on hemophilia B gene therapy

Integrated motivational interviewing and CBT effective for treatment of generalized anxiety disorder

Antibodies given within one day of SHIV exposure can clear the virus

GEMINI LTS study: Patients with active ulcerative colitis report clinical improvements with vedolizumab treatment

Metabolite in gut microbiome could improve outcomes after bone marrow transplant

Stress management can cut risk of another heart attack by half

LEO Pharma announces scientific approval of Enstilar for treatment of people living with psoriasis in EU

Study assesses acceptability of alternative drug to prevent malaria among pregnant women in Kenya

Novel compound shows promise as potential treatment for acute myeloid leukemia

Simple TB screening and isoniazid can be effective for HIV patients at risk for TB

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