Protein C News and Research

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Novel approach allows islet transplants to survive and control diabetes

In type 1 diabetes, an autoimmune response attacks the pancreas's insulin-producing beta cells, leading to marked fluctuations in blood sugar levels. Lifelong daily insulin treatments are standard for patients, but replacing lost beta cells through transplants of islets, a group of cells in the pancreas, represents an attractive option.

13 May 2022

Artificial proteins as specific and versatile neutralizing binders targeting the spike of SARS-CoV-2

Researchers demonstrated that the biosynthetic proteins called αReps addressing the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein could be novel SARS-CoV-2 antivirals

13 May 2022

Study shows how co-transplanting islet cells with SA-FasL-microgels reverses diabetic symptoms

Islet cell transplants are a promising treatment that can cure difficult-to-treat type 1 diabetes. The cells, taken from a donor pancreas, provide patients with a sustainable and tightly controlled source of insulin.

13 May 2022

New discovery has potential to stop inflammation at the "growing end"

Redness, swelling, pain - these are signs of inflammation. It serves to protect the body from pathogens or foreign substances.

13 May 2022

Direct infection and replication of influenza virus in cardiomyocytes is a primary determinant of cardiac pathology associated with severe influenza

Researchers generated a recombinant influenza virus expressing micro ribonucleic acid (miRNAs) expressed in cardiomyocytes to infect mice, which served as a model to study the etiology of influenza-associated cardiac pathology.

13 May 2022

Study explores macromolecular viral entry inhibitors as broad-spectrum first-line antivirals with anti-SARS-CoV-2 activities

Researchers created polystyrene sulfonate with significantly different molar masses, constructed these polymers as an exterior around spherical gold nanoparticles of various sizes to improve multivalency effects, measured antiviral effects of the antivirals on numerous viruses in vitro, and investigated the method of interaction of the leads with SARS-CoV-2 and lentiviral particles.

13 May 2022

Researchers discover new gene that confers resistance to prostate cancer treatment

Northwestern Medicine investigators have identified a gene that confers resistance to a common prostate cancer treatment, according to a study published in Cancer Research.

13 May 2022

Researchers identify compounds from Aspergillus that may be effective against SARS-CoV-2

Researchers from Ain Shams University have been exploring the use of compounds isolated from Aspergillus sp. against SARS-CoV-2.

13 May 2022

Investigating effectiveness of mRNA booster against SARS-CoV-2 Omicron in individuals primed with mRNA or inactivated virus vaccines

Scientists have determined the effectiveness of different vaccination regimens in eliciting humoral immune responses against the SARS-CoV-2 Omicron variant.

13 May 2022

Study reveals serum proteomic signatures of long COVID patients

In a recent study posted to the bioRxiv*preprint server, researchers evaluated the serum proteomic signatures of long coronavirus disease (COVID) patients.

13 May 2022

SARS-CoV-2 N-terminal domain modulates S1/S2 cleavage and spike-mediated functions

In a recent study posted to the bioRxiv* preprint server, researchers explored the role of the N-terminal domain (NTD) of the severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) spike (S) protein in SARS-CoV-2 fusion with the host membranes and coronavirus disease 2019 (COVID-19).

12 May 2022

Bayesian viral allele selection for SARS-CoV-2 genomic surveillance

In a recent study posted to the bioRxiv* preprint server, researchers assessed the selection effects in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) using Bayesian viral allele selection.

12 May 2022

An Ad5 vectored COVID vaccine expressing an S1-N fusion protein

In a recent study posted to the bioRxiv* preprint server, researchers characterized the development of multiple adenovirus-vectored and subunit recombinant protein severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine candidates.

12 May 2022

Cost-effective ovine antibody-based therapy against SARS-CoV-2 infection

A recent study published in the journal Antiviral Research explored alternative sources of polyclonal antibodies against SARS-CoV-2, which would be more cost-effective, amendable to regulatory approval, and widespread use.

12 May 2022

T-cell responses after COVID-19 and vaccinations

A new study published in the journal Frontiers in immunology examines the cell-mediated immunity in BNT162b2 COVID-19 mRNA vaccinated health care workers and COVID-19 patients.

12 May 2022

Repeated DNA sequences in the genome may contribute to schizophrenia risk

Researchers at The Hospital for Sick Children (SickKids) and Centre for Addiction and Mental Health (CAMH) have found that repeated DNA sequences in the genome may contribute to an individual's risk of developing schizophrenia.

12 May 2022

Enzyme discovery offers new way to regulate cell death process for inflammatory diseases

A WEHI-led study has identified a new enzyme involved in controlling cell death, in findings that could lead to better treatment options for a range of inflammatory conditions, cancers and viruses.

12 May 2022

Study shows how MS patients treated with Rituximab react to COVID-19 vaccination

MS patients treated with Rituximab have better responses to the COVID-19 vaccine if they have higher B cell counts.

12 May 2022

Mitochondrial respiratory chain is essential for NLRP3 inflammasome activation

Northwestern Medicine investigators recently discovered that the mitochondrial respiratory chain — a series of protein complexes essential for a cellular respiration and energy production — is necessary for the activation of another protein complex linked to inflammation and the progression of chronic diseases, according to a study published in Nature Immunology.

12 May 2022

Phase 1 trial of COVID-19 PTXCOVID19-B vaccine

A new study demonstrated that the SARS-CoV-2 PTXCOVID19-B vaccine was a promising SARS-CoV-2 vaccine option.

12 May 2022

Protein C News and Research

Novel approach allows islet transplants to survive and control diabetes

Artificial proteins as specific and versatile neutralizing binders targeting the spike of SARS-CoV-2

Study shows how co-transplanting islet cells with SA-FasL-microgels reverses diabetic symptoms

New discovery has potential to stop inflammation at the "growing end"

Direct infection and replication of influenza virus in cardiomyocytes is a primary determinant of cardiac pathology associated with severe influenza

Study explores macromolecular viral entry inhibitors as broad-spectrum first-line antivirals with anti-SARS-CoV-2 activities

Researchers discover new gene that confers resistance to prostate cancer treatment

Researchers identify compounds from Aspergillus that may be effective against SARS-CoV-2

Investigating effectiveness of mRNA booster against SARS-CoV-2 Omicron in individuals primed with mRNA or inactivated virus vaccines

Study reveals serum proteomic signatures of long COVID patients

SARS-CoV-2 N-terminal domain modulates S1/S2 cleavage and spike-mediated functions

Bayesian viral allele selection for SARS-CoV-2 genomic surveillance

An Ad5 vectored COVID vaccine expressing an S1-N fusion protein

Cost-effective ovine antibody-based therapy against SARS-CoV-2 infection

T-cell responses after COVID-19 and vaccinations

Repeated DNA sequences in the genome may contribute to schizophrenia risk

Enzyme discovery offers new way to regulate cell death process for inflammatory diseases

Study shows how MS patients treated with Rituximab react to COVID-19 vaccination

Mitochondrial respiratory chain is essential for NLRP3 inflammasome activation

Phase 1 trial of COVID-19 PTXCOVID19-B vaccine

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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