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Review highlights oncolytic viruses with remarkable ability to destroy cancer cells

With the world still in the grip of a devastating pandemic, it's hard to imagine viruses as something other than hostile enemies to be vanquished.

30 Nov 2021

New combination treatment enables complete tumor regression in mice with high-risk neuroblastoma

In mice with high-risk neuroblastoma, tumors disappeared in response to a new combination treatment with precision medicines, a recent study from University of Gothenburg researchers shows.

30 Nov 2021

Northwestern researchers continue to tackle every facet of COVID-19 pandemic

As the COVID-19 pandemic nears the two-year mark, Northwestern Medicine scientists continue to tackle every facet of the disease, from investigating coronavirus vaccines' potential for providing immunity against similar coronaviruses to developing novel rapid antigen-based tests and examining disparities in COVID-19 case and mortality rates in Chicago.

30 Nov 2021

First-of-its-kind PET imaging-based tool developed to detect liver inflammation in NAFLD patients

A UC Davis Health team has developed a first-of-its-kind positron emission tomography (PET) scan imaging-based tool to detect liver inflammation in patients affected with non-alcoholic fatty liver disease.

30 Nov 2021

Omicron and other coronavirus variants: What you need to know

Americans, already weary of a pandemic nearly two years long, were dealt a new blow during the long Thanksgiving weekend: the announcement that a new coronavirus variant had emerged.

30 Nov 2021

Structure-guided virtual screening identifies novel SARS-CoV-2 Mpro inhibitors

A new paper deals with the identification of an antiviral compound that could help in developing additional drugs to help fight COVID-19.

30 Nov 2021

Study on molnupiravir precursor NHC antiviral activity against SARS-CoV-2 variants of concern

In a new study, published on the bioRxiv* preprint server, scientists aimed to determine the reaction of the molnupiravir parent drug (NHC) to different SARS-CoV-2 Variants of Concern (VoCs). They also sought to establish the therapeutic window in a human lung cell model.

29 Nov 2021

The mode of action of essential proteins involved in cancer and Alzheimer´s deciphered

The proteins that belong to the HAT family are essential for life as they transport amino acids across the cell membrane. Although the members of this family are practically identical, some transport certain amino acids and not others.

29 Nov 2021

Clinical drug research for the treatment of CNS and neurological disorders

Frontiers in Clinical Drug Research - CNS and Neurological Disorders is a book series that brings updated reviews to readers interested in advances in the development of pharmaceutical agents for the treatment of central nervous system (CNS) and other nerve disorders.

29 Nov 2021

SPORE-funded Kidney Cancer Program at UT Southwestern reports wide array of tumor models to date

Funded by a Specialized Program of Research Excellence award from the National Cancer Institute (NCI), the Kidney Cancer Program at UT Southwestern's Harold C. Simmons Comprehensive Cancer Center reports the largest and most diverse catalog of kidney cancer tumor models to date.

29 Nov 2021

Heart failure patients may benefit from common type 2 diabetes drug

Dapagliflozin, a drug commonly used to treat type 2 diabetes, improved symptoms and physical limitations in patients with heart failure with preserved ejection fraction, according to clinical trial results published in Nature Medicine.

29 Nov 2021

Study uncovers mechanism for insensitivity to key antimalarial drug in new pathogen variant

Malaria is one of the most dangerous infectious diseases. The causative pathogens are microorganisms of the genus Plasmodium.

29 Nov 2021

Study finds atazanavir inhibits main SARS-CoV-2 protease

Research shows that ATV has different antiviral activity compared to PAXLOVID™, encouraging further research.

29 Nov 2021

Complex RNA structures could have untapped therapeutic potential in the fight against COVID-19

To the untrained eye, the loops, kinks and folds in the single strand of RNA that makes up the coronavirus genome look like a jumble of spaghetti or tangled yarn. But to researchers like Amanda Hargrove, a chemistry professor at Duke University, the complex shapes that RNA takes on as it folds upon itself could have untapped therapeutic potential in the fight against COVID-19.

26 Nov 2021

Antiviral activity of a photoactivable natural product on coronaviruses

A new study showed that pheophorbide a has antiviral activity against many CoVs.

26 Nov 2021

Combination of two targeted drugs shows "clinically meaningful" activity in some malignant brain tumors

A combination of two targeted cancer drugs showed unprecedented, "clinically meaningful" activity in patients with highly malignant brain tumors that carried a rare genetic mutation, according to a clinical trial report by investigators from Dana-Farber Cancer Institute.

25 Nov 2021

Days of extreme heat associated with increased risk of emergency department visits

Extremely hot days with an average temperature of 34.4°C (93.9°F) are associated with a higher risk of emergency department visits among adults of all ages, finds a large study from the United States published by The BMJ today.

25 Nov 2021

Using metal nanoparticles to fight SARS-CoV-2

A recent review article looks at the potential of nanotechnology in fighting severe acute respiratory syndrome 2 (SARS-CoV-2), with several possibilities of strategies in therapeutics, vaccines, and prevention.

25 Nov 2021

International collaboration secures €1M grant to investigate new treatment target for lymphoma

An international collaboration involving researchers from Queen Mary University of London, Memorial Sloan Kettering Cancer Center, New York and Dana-Farber Cancer Institute, Boston has secured a €1M research grant from Dutch blood cancer charity, Lymph&Co, to investigate a new treatment target for lymphoma.

25 Nov 2021

What may the future hold in terms of SARS-CoV-2 variants?

Researchers fit data on SARS-CoV-2 variants by exploiting a function that depends on the global number of infected cases since the start of the pandemic.

25 Nov 2021

Drugs News and Research

Review highlights oncolytic viruses with remarkable ability to destroy cancer cells

New combination treatment enables complete tumor regression in mice with high-risk neuroblastoma

Northwestern researchers continue to tackle every facet of COVID-19 pandemic

First-of-its-kind PET imaging-based tool developed to detect liver inflammation in NAFLD patients

Omicron and other coronavirus variants: What you need to know

Structure-guided virtual screening identifies novel SARS-CoV-2 Mpro inhibitors

Study on molnupiravir precursor NHC antiviral activity against SARS-CoV-2 variants of concern

The mode of action of essential proteins involved in cancer and Alzheimer´s deciphered

Clinical drug research for the treatment of CNS and neurological disorders

SPORE-funded Kidney Cancer Program at UT Southwestern reports wide array of tumor models to date

Heart failure patients may benefit from common type 2 diabetes drug

Study uncovers mechanism for insensitivity to key antimalarial drug in new pathogen variant

Study finds atazanavir inhibits main SARS-CoV-2 protease

Complex RNA structures could have untapped therapeutic potential in the fight against COVID-19

Antiviral activity of a photoactivable natural product on coronaviruses

Combination of two targeted drugs shows "clinically meaningful" activity in some malignant brain tumors

Days of extreme heat associated with increased risk of emergency department visits

Using metal nanoparticles to fight SARS-CoV-2

International collaboration secures €1M grant to investigate new treatment target for lymphoma

What may the future hold in terms of SARS-CoV-2 variants?

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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