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Low-carb diet burns more excess liver fat than low-cal diet

People on low-carbohydrate diets are more dependent on the oxidation of fat in the liver for energy than those on a low-calorie diet, researchers at UT Southwestern Medical Center have found in a small clinical study.

23 Jan 2009

Genetic interactions are the key to understanding complex traits

In recent years, genetic studies have uncovered hundreds of DNA variations linked to common diseases, such as cancer or diabetes, raising the prospect that scientists can gauge disease risk based on information in an individual's genome.

23 Jan 2009

Lisofylline drug improves type 2 insulin action; reduces harm of fat in preclinical study

Results of a preclinical study involving DiaKine Therapeutics' lead drug candidate Lisofylline (LSF) indicate the compound may reduce two key risk factors for type 2 diabetes.

23 Jan 2009

Morbidity rates increased substantially after Hurricane Katrina

In the year following Hurricane Katrina, the health of survivors 65 and over declined nearly 4 times that of a national sample of older adults not affected by the disaster, according to a study led by researchers at the Johns Hopkins Bloomberg School of Public Health.

23 Jan 2009

Topical treatment wipes out herpes with RNAi

Whether condoms or abstinence, most efforts to prevent sexually transmitted diseases have a common logic: keep the pathogen out of your body altogether.

21 Jan 2009

Discovery could lead to novel arrhythmia treatments

Abnormal heart rhythms - arrhythmias - are killers. They strike without warning, causing sudden cardiac death, which accounts for about 10 percent of all deaths in the United States.

21 Jan 2009

Slices of living human brain tissue are helping scientists identify new stroke therapies

Slices of living human brain tissue are helping scientists learn which drugs can block the waves of death that engulf and engorge brain cells following a stroke.

21 Jan 2009

Lou Gehrig's disease in humans has genetic links to degenerative myelopathy in dogs

An incurable, paralyzing disease in humans is now genetically linked to a similar disease in dogs.

21 Jan 2009

Protease inhibitor found to aid diabetic retinopathy treatment

Researchers from Joslin Diabetes Center, Boston, and ActiveSite Pharmaceuticals, Inc., San Francisco, announced today that they have demonstrated that a specific inhibitor of the protease plasma kallikrein, ASP-440, developed by ActiveSite Pharmaceuticals, may provide a new therapeutic approach for treatment of diabetic retinopathy, the most common eye-related complication of diabetes.

21 Jan 2009

Loss of sex drive after menopause affects health, quality of life

Women with low levels of sexual desire, often as a result of menopause, are more likely to be depressed and to suffer physical symptoms such as back pain and memory problems than women who report higher levels of desire, according to a new study by researchers at the University of North Carolina at Chapel Hill and Procter & Gamble Pharmaceuticals.

21 Jan 2009

Oral steroids ineffective treatment for wheezing in children

A new study from Barts and The London School of Medicine and Dentistry has found that a common treatment for wheezing in preschool children is no more effective than a placebo.

21 Jan 2009

Potential new target in the war on HIV/AIDS

The study revealed that a variant of a protein involved in HIV pathogenesis can suppress production of an HIV protein, known as Nef. Nef is required for the human immunodeficiency virus to develop into AIDS through a series of complex events involving viral elements and cellular proteins. Nef has never been a target for drug treatment in HIV patients.

21 Jan 2009

Impaired kidney function raises risk of heart problems in the elderly

A study published next week in the open access journal PLoS Medicine suggests that elderly people with damaged kidneys are at greater risk of cardiovascular disease, such as heart failure and stroke, and other causes of mortality.

21 Jan 2009

Researchers show how anthracycline class of chemotherapeutics block blood vessel growth, slow cancer spread

Researchers at the Johns Hopkins University School of Medicine have discovered how a whole class of commonly used chemotherapy drugs can block cancer growth.

21 Jan 2009

Topical microbicide protects against genital herpes

A topical microbicide that silences two genes can safely protect against genital herpes infection for as long as one week, according to a joint study by researchers at the Albert Einstein College of Medicine of Yeshiva University and Harvard Medical School.

21 Jan 2009

Too much weight loss can be a bad thing

Doctors are not doing enough to pick up on problems with excessive weight loss, says a Saint Louis University physician who helped draft recent guidelines to diagnose the condition called "cachexia" (kuh-kex-ee-uh).

21 Jan 2009

More scientific evidence supporting Darwinian views of evolution

Studies at the University of Pennsylvania School of Medicine on brain electrical signaling offer a fresh perspective on vertebrate evolution, provide additional evidence supporting Darwinian views of evolution, and may also lead to more effective treatment of epileptic seizures in infants.

21 Jan 2009

Engineered virus targets and kills apparent cancer stem cells in neuroblastoma

After identifying an apparent population of cancer stem cells for neuroblastoma, researchers successfully used a reprogrammed herpes virus to block tumor formation in mice by targeting and killing the cells.

21 Jan 2009

Mentally ill, the disabled and ethnic minorities more susceptible to terrorism fears

Research has shown that certain marginalized groups - including the mentally ill, the disabled and ethnic minorities such as African Americans and Latinos - fare worse than others in the aftermath of natural disasters, suffering disproportionate impoverishment, injuries and fatalities.

21 Jan 2009

Newly discovered protein acts as virus alarm

The Center for Molecular Medicine of the Austrian Academy of Sciences (CeMM) announces the discovery of a new molecular sensor in human cells capable of recognizing infecting viruses and transmitting an alarm signal to the body.

21 Jan 2009