Enzyme News and Research

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Three cups of coffee per day reduce liver cancer risk by more than 50%

Coffee consumption reduces risk of hepatocellular carcinoma (HCC), the most common type of liver cancer, by about 40 percent, according to an up-to-date meta-analysis published in Clinical Gastroenterology and Hepatology, the official clinical practice journal of the American Gastroenterological Association.

23 Oct 2013

Nanopharmaceutical drug shows promise for cancers that resist antiangiogenic drugs

The nanopharmaceutical drug CRLX101 is showing promise as a potential new treatment for cancers that develop resistance to antiangiogenic drugs and radiation therapy, according to clinical trial results presented here at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, held Oct. 19 - 23.

22 Oct 2013

Scientist receives NIH New Innovator Award to design innovative approaches for cancer treatment

Derek Taylor, PhD, a member of the Case Western Reserve School of Medicine, has been awarded the prestigious New Innovator Award by the National Institutes of Health (NIH).

22 Oct 2013

Researchers discover link between NOX4 enzyme and osteoporosis

Genkyotex, the leading developer of NOX enzyme inhibitors, announced today that a group of collaborators have discovered a link between the enzyme NOX4 and development of osteoporosis.

21 Oct 2013

Atorvastatin drug plus zoledronic acid may help treat toxoplasmosis

Researchers at the University of Georgia have discovered that a combination of two commonly prescribed drugs used to treat high cholesterol and osteoporosis may serve as the foundation of a new treatment for toxoplasmosis, a parasitic infection caused by the protozoan Toxoplasma gondii. They published their findings recently in PLOS Pathogens.

18 Oct 2013

Nintedanib drug to treat NSCLC is submitted for approval from European Medicines Agency

Boehringer Ingelheim announced the submission of a Marketing Authorisation Application to the European Medicines Agency for the approval of its oral triple angiokinase inhibitor nintedanib, in combination with docetaxel, for the treatment of patients with locally advanced, metastatic or recurrent non-small cell lung cancer (NSCLC) of adenocarcinoma tumour histology after first line chemotherapy.

17 Oct 2013

BRAF inhibitor vemurafenib effective for patients with papillary thyroid cancer

Mutations in a gene that codes for the enzyme BRAF kinase have been associated with increased risk for papillary thyroid cancer. An early-stage clinical trial of the BRAF inhibitor vemurafenib resulted in either a partial response or stable disease in patients with PTC and BRAF mutations.

17 Oct 2013

Researchers find novel drug target for anaplastic thyroid carcinomas

Anaplastic thyroid carcinomas are aggressive tumors that do not respond to traditional radio- or chemotherapeutic agents, and there currently is no cure or effective treatment available. Median survival from diagnosis is 5 months, and although ATC accounts for only 1.7% of all thyroid cancers in the U.S., it is responsible for a large proportion of thyroid cancer-related deaths.

17 Oct 2013

Scientists uncover faulty brain mechanism that may underlie schizophrenia in humans

Working with mice genetically engineered to display symptoms of schizophrenia, neuroscientists at the RIKEN-MIT Center for Neural Circuit Genetics at the Picower Institute for Learning and Memory at MIT have uncovered a faulty brain mechanism that may underlie schizophrenia and other psychiatric disorders in humans.

17 Oct 2013

Spraying plant hormone on broccoli may boost cancer-fighting potential

Spraying a plant hormone on broccoli - already one of the planet's most nutritious foods - boosts its cancer-fighting potential, and researchers say they have new insights on how that works.

17 Oct 2013

Simple urine test uses nanotechnology to detect dangerous blood clotting

Life-threatening blood clots can form in anyone who sits on a plane for a long time, is confined to bed while recovering from surgery, or takes certain medications.

17 Oct 2013

Certain blood pressure medications may reduce risk of dementia due to Alzheimer's disease

A Johns Hopkins-led analysis of data previously gathered on more than 3,000 elderly Americans strongly suggests that taking certain blood pressure medications to control blood pressure may reduce the risk of dementia due to Alzheimer's disease.

17 Oct 2013

Researchers develop new method to produce artificial membranes using nanoscaled tip

Researchers around Dr. Michael Hirtz from Karlsruhe Institute of Technology and Dr. Aravind Vijayaraghavan from the University of Manchester have developed a new method to produce artificial membranes: Using a nanoscaled tip, they write tailored patches of phospholipid membrane onto a graphene substrate.

16 Oct 2013

Researchers develop innovative 3D method to grow miniature pancreas from progenitor cells

An international team of researchers from the University of Copenhagen have successfully developed an innovative 3D method to grow miniature pancreas from progenitor cells. The future goal is to use this model to help in the fight against diabetes. The research results has just been published in the scientific journal Development.

16 Oct 2013

UC researchers receive $2.1M grant from NIH to study molecular mechanisms of muscle fatigue

University of Cincinnati (UC) researchers have been awarded a five-year, $2.1 million grant from the National Institutes of Health (NIH) to study an isoform that plays a critical role in human resistance to fatigue.

16 Oct 2013

Key marker in blood and urine identifies genetic mutations in gene responsible for RP

Research led by physician-scientists at Bascom Palmer Eye Institute of the University of Miami Miller School of Medicine has produced a breakthrough discovery in diagnosing retinitis pigmentosa, a blinding disease that affects about 1 in 4,000 people in the United States.

16 Oct 2013

People who lower stress levels through meditation, yoga have longer telomeres

Targeting telomeres, the protective caps at the end of all chromosomes that are critical to healthy cell function, T.A. Sciences' products activate an enzyme that can slow down and possibly reverse age- and lifestyle-related telomere shortening. Short telomeres can cause mutations and degradations to chromosomes leading to loss of cell functionality. Its inaugural product, TA-65 is the only proven product specifically focused on the telomerase activation market.

12 Oct 2013

Astrazeneca, Janssen To Promote Novel Prostate Cancer Treatment In Japan

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11 Oct 2013

HSCI researchers discover on-off switch for gene expression

Harvard Stem Cell Institute researchers have settled a century-old debate over whether occurrence of DNA methylation acts to silence gene expression, or if genes are turned off by other means before they are methylated.

11 Oct 2013

TSRI scientists discover viable strategy for weight loss in people

Scientists at The Scripps Research Institute have discovered key details of a brain-to-body signaling circuit that enables roundworms to lose weight independently of food intake. The weight-loss circuit is activated by combined signals from the worm versions of the neurotransmitters serotonin and adrenaline, and there are reasons to suspect that it exists in a similar form in humans and other mammals.

11 Oct 2013

Enzyme News and Research

Three cups of coffee per day reduce liver cancer risk by more than 50%

Nanopharmaceutical drug shows promise for cancers that resist antiangiogenic drugs

Scientist receives NIH New Innovator Award to design innovative approaches for cancer treatment

Researchers discover link between NOX4 enzyme and osteoporosis

Atorvastatin drug plus zoledronic acid may help treat toxoplasmosis

Nintedanib drug to treat NSCLC is submitted for approval from European Medicines Agency

BRAF inhibitor vemurafenib effective for patients with papillary thyroid cancer

Researchers find novel drug target for anaplastic thyroid carcinomas

Scientists uncover faulty brain mechanism that may underlie schizophrenia in humans

Spraying plant hormone on broccoli may boost cancer-fighting potential

Simple urine test uses nanotechnology to detect dangerous blood clotting

Certain blood pressure medications may reduce risk of dementia due to Alzheimer's disease

Researchers develop new method to produce artificial membranes using nanoscaled tip

Researchers develop innovative 3D method to grow miniature pancreas from progenitor cells

UC researchers receive $2.1M grant from NIH to study molecular mechanisms of muscle fatigue

Key marker in blood and urine identifies genetic mutations in gene responsible for RP

People who lower stress levels through meditation, yoga have longer telomeres

Astrazeneca, Janssen To Promote Novel Prostate Cancer Treatment In Japan

HSCI researchers discover on-off switch for gene expression

TSRI scientists discover viable strategy for weight loss in people

Measuring Drug-Target Residence Times with Biochemical Assays eBook

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