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Dysregulation of innate lymphoid cells drives colon cancer progression and immunotherapy resistance

An immune cell subset called innate lymphoid cells (ILC3s) protects against colorectal cancer, in part by helping to maintain a healthy dialogue between the immune system and gut microbes, according to a new study led by researchers at Weill Cornell Medicine and NewYork-Presbyterian. The finding opens the door to new strategies for treating this type of cancer.

17 Aug 2021

Specific leukemia gene mutations exert divergent effects on DNA repair and sensitivity to PARP Inhibitors

In a recent study published in Cancer Research, researchers from Fels Cancer Institute for Personalized Medicine at the Lewis Katz School of Medicine at Temple University and Fox Chase Cancer Center identified specific leukemia gene mutations and the mechanisms by which they regulate DNA repair and respond to PARP inhibitors.

13 Aug 2021

Study highlights the significance of screening for pre-cancerous Barrett’s esophagus

Abnormal cells that go on develop into oesophageal cancer – cancer that affects the tube connecting the mouth and stomach – start life as cells of the stomach, according to scientists at the University of Cambridge.

13 Aug 2021

Immunotherapy pairs ultrasound with immune cells to destroy tumors without toxic side effects

Bioengineers at the University of California San Diego have developed a cancer immunotherapy that pairs ultrasound with cancer-killing immune cells to destroy malignant tumors while sparing normal tissue.

12 Aug 2021

New study offers insight into how high-risk form of blood cancer can develop in children

In some children with acute myeloid leukemia, cancer cells have the same amount of DNA changes as healthy blood stem cells.

6 Aug 2021

Economic mobility associated with racial mortality gaps in the United States

A new study suggests structural racism measured by the racial economic mobility gap between Black and White persons with a similar parental income (as an indicator of similar childhood socioeconomic status) is strongly associated with Black-White disparities in mortality in the United States, both in a recent birth cohort and in all ages combined.

4 Aug 2021

New integrative NGS panel for analysis of standard and novel biomarkers in lymphoid neoplasms

Increasing knowledge about genomic biomarkers has facilitated better monitoring and personalized management of patients with B-cell malignant tumors.

29 Jul 2021

ASCCP voices support for 2020 ACS guidelines, recognizes the need to shift to primary HPV screening

Last year, the American Cancer Society (ACS) issued an updated set of guidelines for cervical cancer screening - emphasizing the shift toward screening with primary human papillomavirus (HPV) testing.

26 Jul 2021

EWG study recommends stringent health-based standards for radiation exposure from wireless devices

A peer-reviewed study by the Environmental Working Group recommends stringent health-based exposure standards for both children and adults for radiofrequency radiation emitted from wireless devices. EWG's children's guideline is the first of its kind and fills a gap left by federal regulators.

20 Jul 2021

Study reveals pathological mechanism and treatment strategy of pre-engraftment syndrome

The research team led by Prof. WEI Haiming and Prof. TIAN Zhigang from Division of Life Sciences and Medicine, University of Science and Technology of China of the Chinese Academy of Sciences, collaborating with the research group led by Prof. SUN Zimin from the First Affiliated Hospital of USTC revealed the pathological mechanism of severe pre-engraftment syndrome (PES) after umbilical cord blood transplantation, not only providing a treatment strategy for patients with PES, but significantly guiding for further improvement in the curative effect of unrelated cord blood transplantation (UCBT).

19 Jul 2021

Scientists divide all cancers into two categories

All cancers fall into just two categories, according to new research from scientists at Sinai Health, in findings that could provide a new strategy for treating the most aggressive and untreatable forms of the disease.

16 Jul 2021

RUDN University biologists discover the way how macrophages respond to inflammation

RUDN University biologists discovered the way how macrophages (the cells of the "first line" immune response) respond to inflammation and identified how the immune response depends on their origin.

16 Jul 2021

$50,000 grant to help explore the use of turmeric for reducing joint pain in breast cancer patients

UC Davis Comprehensive Cancer Center received a $50,000 grant from the Safeway Foundation to explore the use of the South Asian spice Turmeric as a way of reducing joint pain in breast cancer patients being treated with anti-estrogen drugs.

16 Jul 2021

A small molecule inhibitor shows promise to reduce the growth of uveal melanoma

Uveal melanoma, or UM, is a rare and deadly cancer of the eye, and the mortality rate has remained unimproved for 40 years. Half of the melanomas spread to other organs of the body, causing death in less than a year, so new treatments to preserve vision and prevent death are an urgent need.

15 Jul 2021

Drug combination found to be safe and effective in malignant peritoneal mesothelioma patients

A phase II study led by researchers from The University of Texas MD Anderson Cancer Center found that treatment with atezolizumab and bevacizumab was well-tolerated and resulted in a 40% objective response rate in patients with advanced malignant peritoneal mesothelioma, a rare cancer in the lining of the abdomen.

14 Jul 2021

Pfizer-BioNTech’s COVID-19 vaccine effective and safe for use among cancer patients

Researchers in Israel have conducted a study showing that the use of Pfizer-BioNTech’s coronavirus disease 2019 (COVID-19) vaccine appears to be safe and effective among patients with cancer.

11 Jul 2021

MRI screening and targeted biopsies could reduce overdiagnoses of prostate cancer

Most countries have not introduced nationwide prostate-cancer screening, as current methods result in overdiagnoses and excessive and unnecessary biopsies. A new study by researchers at Karolinska Institutet in Sweden, which is published in The New England Journal of Medicine, indicates that screening by magnetic resonance imaging (MRI) and targeted biopsies could potentially cut overdiagnoses by half.

9 Jul 2021

Researchers propose a new non-invasive method to distinguish thyroid nodules from cancer

A lump in the thyroid gland is called a thyroid nodule, and 5-10% of all thyroid nodules are diagnosed as thyroid cancer.

9 Jul 2021

Scientists discover potential marker for the success of immunotherapy in lung cancer patients

Lung cancer has the highest mortality rate of all cancers, and treatment options are extremely limited, especially for patients with oncogenic mutations in the KRAS gene.

8 Jul 2021

Novel tool enables multi-resolution characterization of molecular taxonomies

The discovery of novel groups or categories within diseases, organisms and biological processes and their organization into hierarchical relationships are important and recurrent pursuits in biology and medicine, which may help elucidate group-specific vulnerabilities and ultimately novel therapeutic interventions.

8 Jul 2021

Malignant News and Research

Dysregulation of innate lymphoid cells drives colon cancer progression and immunotherapy resistance

Specific leukemia gene mutations exert divergent effects on DNA repair and sensitivity to PARP Inhibitors

Study highlights the significance of screening for pre-cancerous Barrett’s esophagus

Immunotherapy pairs ultrasound with immune cells to destroy tumors without toxic side effects

New study offers insight into how high-risk form of blood cancer can develop in children

Economic mobility associated with racial mortality gaps in the United States

New integrative NGS panel for analysis of standard and novel biomarkers in lymphoid neoplasms

ASCCP voices support for 2020 ACS guidelines, recognizes the need to shift to primary HPV screening

EWG study recommends stringent health-based standards for radiation exposure from wireless devices

Study reveals pathological mechanism and treatment strategy of pre-engraftment syndrome

Scientists divide all cancers into two categories

RUDN University biologists discover the way how macrophages respond to inflammation

$50,000 grant to help explore the use of turmeric for reducing joint pain in breast cancer patients

A small molecule inhibitor shows promise to reduce the growth of uveal melanoma

Drug combination found to be safe and effective in malignant peritoneal mesothelioma patients

Pfizer-BioNTech’s COVID-19 vaccine effective and safe for use among cancer patients

MRI screening and targeted biopsies could reduce overdiagnoses of prostate cancer

Researchers propose a new non-invasive method to distinguish thyroid nodules from cancer

Scientists discover potential marker for the success of immunotherapy in lung cancer patients

Novel tool enables multi-resolution characterization of molecular taxonomies

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