Metastasis News and Research

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Metastasis is the spread of cancer from one part of the body to another. A tumor formed by cells that have spread is called a “metastatic tumor” or a “metastasis.” The metastatic tumor contains cells that are like those in the original (primary) tumor. The plural form of metastasis is metastases

Arteriolar niche used by breast cancer cells to prepare for metastasis

More than 43,000 American women will die from breast cancer this year. Most of those deaths will occur after the cancer has spread to other organs, a process called metastasis. This involves at least five major steps.

19 Aug 2021

Understanding how to regulate key enzyme may lead to new treatments for cancers, viral infections

A new study led by University of California, Irvine (UCI) researchers identifies two ways in which APOBEC3A - a vital enzyme that is responsible for genetic changes resulting in a variety of cancers while protecting our cells against viral infection - is controlled.

13 Aug 2021

Understanding hypoxia-induced gene expression variations in aggressive type of pancreatic cancer

Cancer cells have evolved a myriad of mechanisms that support their uncontrolled growth. In case of solid tissue tumors, the tumor microenvironment, which consists of extracellular components and conditions surrounding the tumor, is crucial in deciding the fate of the cancer cells.

11 Aug 2021

Study may provide a new therapeutic target for treatment of LUAD patients

Aging-US published "A novel ferroptosis-related gene signature for prognostic prediction of patients with lung adenocarcinoma" which reported that RNA-seq transcriptome data of LUAD patients were obtained from The Cancer Genome Atlas database.

9 Aug 2021

New recommendations for diagnosis and treatment of brain metastases from solid tumors

Brain metastases are a common and dangerous complication in cancer patients. Under the leadership of experts from MedUni Vienna, two of the largest international oncology societies have published new clinical guidelines for the diagnosis and treatment of brain metastases from solid tumors.

9 Aug 2021

MRI texture features can predict response to neoadjuvant chemotherapy in patients with breast cancer

Oncotarget published "MRI texture features from tumor core and margin in the prediction of response to neoadjuvant chemotherapy in patients with locally advanced breast cancer" which reported that the authors investigated whether pre-treatment T2-weighted magnetic resonance imaging can be used to predict response to neoadjuvant chemotherapy in breast cancer.

6 Aug 2021

Researchers develop the most comprehensive molecular map of lung squamous cell carcinoma

Lung cancer remains the leading cause of cancer-associated death in the United States and worldwide. Patients with a subtype called lung adenocarcinoma (LUAD) have benefited from the development of new targeted medicines, but the search for effective new therapies for another subtype called lung squamous cell carcinoma (LSCC) has largely come up short.

5 Aug 2021

Researchers use AI to assess metastatic potential of melanoma cells

Using artificial intelligence (AI), researchers from UT Southwestern have developed a way to accurately predict which skin cancers are highly metastatic.

5 Aug 2021

Discovery may enable the development of new therapies to kill aggressive cancer cells

Vanderbilt faculty and researchers are looking for the "Achilles' heel" of the cancer cells that survive initial chemotherapy.

3 Aug 2021

Experimental model shows how topological defects in the mesothelium affect ovarian cancer metastasis

Ovarian cancer devastates more than 20,000 women in the U.S. every year, due in part to its tendency to evade detection and present after metastatic spread. A key element to slowing metastasis is understanding the mechanisms of how tumor cells invade tissues.

3 Aug 2021

Anti-parasitic drug prevents pancreatic cancer's initiation, progression and metastasis in mice

As the third-most lethal cancer in the United States, with only a 1% five-year survival rate for people with its most aggressive form, pancreatic cancer has long been a target of researchers who search for ways to slow or stop its growth and spread.

3 Aug 2021

Hormone-resistant prostate, breast cancers added to clinical trial of experimental DNA therapy

The Republic of Belarus Ministry of Health has approved expanding the ongoing clinical trial of CureLab Oncology's Elenagen, an experimental DNA therapy, to include two new arms: 1) hormone-resistant breast cancer; and 2) hormone-resistant metastatic prostate cancer.

3 Aug 2021

Morphle manufactures its 101st slide scanner for NIH’s NCI

Morphle Labs makes its ceremonial 101st scanner for NIH’s National Cancer Institute. It customized the scanner to fit the research needs of NCI.

From Morphle Digital Pathology 3 Aug 2021

Researchers develop ovarian tumor microenvironment-chip to test novel ways to treat the disease

In the evolving field of cancer biology and treatment, innovations in organ-on-a-chip microdevices allow researchers to discover more about the disease outside the human body.

23 Jul 2021

Study elucidates the role of two isoforms of KRAS oncogenes

KRAS was one of the first oncogenes to be identified, a few decades ago. It is among the most common drivers of cancer and its mutations can be detected in around 25 per cent of human tumors.

19 Jul 2021

MIT engineers create new diagnostic nanoparticle that can pinpoint tumor location

Most of the tests that doctors use to diagnose cancer -- such as mammography, colonoscopy, and CT scans -- are based on imaging. More recently, researchers have also developed molecular diagnostics that can detect specific cancer-associated molecules that circulate in bodily fluids like blood or urine.

16 Jul 2021

A small molecule inhibitor shows promise to reduce the growth of uveal melanoma

Uveal melanoma, or UM, is a rare and deadly cancer of the eye, and the mortality rate has remained unimproved for 40 years. Half of the melanomas spread to other organs of the body, causing death in less than a year, so new treatments to preserve vision and prevent death are an urgent need.

15 Jul 2021

Metastasis News and Research

Further Reading

Arteriolar niche used by breast cancer cells to prepare for metastasis

Understanding how to regulate key enzyme may lead to new treatments for cancers, viral infections

Understanding hypoxia-induced gene expression variations in aggressive type of pancreatic cancer

Study may provide a new therapeutic target for treatment of LUAD patients

New recommendations for diagnosis and treatment of brain metastases from solid tumors

MRI texture features can predict response to neoadjuvant chemotherapy in patients with breast cancer

Researchers develop the most comprehensive molecular map of lung squamous cell carcinoma

Researchers use AI to assess metastatic potential of melanoma cells

Discovery may enable the development of new therapies to kill aggressive cancer cells

Experimental model shows how topological defects in the mesothelium affect ovarian cancer metastasis

Anti-parasitic drug prevents pancreatic cancer's initiation, progression and metastasis in mice

Hormone-resistant prostate, breast cancers added to clinical trial of experimental DNA therapy

Morphle manufactures its 101st slide scanner for NIH’s NCI

Researchers develop ovarian tumor microenvironment-chip to test novel ways to treat the disease

Study elucidates the role of two isoforms of KRAS oncogenes

MIT engineers create new diagnostic nanoparticle that can pinpoint tumor location

A small molecule inhibitor shows promise to reduce the growth of uveal melanoma

Mechanical factors play a key role in the natural growth of human organs

Specialized protein appears to regulate key step in cancer metastasis

Anti-androgen therapy for patients with advanced prostate cancer may fuel bone metastasis

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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