Signaling Pathway News and Research

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Study shows why MDS cells have a competitive advantage that supports disease progression

A powerful clue has emerged in a long-running mystery about how the cells of myelodysplastic syndrome (MDS) manage to outcompete normal blood cells to cause a disease state that often leads to leukemia, according to a study published online April 20, 2020, in Nature Immunology.

21 Apr 2020

Tumors commandeer cell death pathway to avoid immune system attack after radiation

Cancer cells avoid an immune system attack after radiation by commandeering a cell signaling pathway that helps dying cells avoid triggering an immune response, a new study led by UTSW scientists suggests.

13 Apr 2020

Molecular pathway responsible for TNBC's progression and spread identified

Immunotherapies have revolutionized treatment for people with a variety of cancers. But when given to those with triple-negative breast cancer, a particularly aggressive form of the disease, less than 20% respond.

13 Apr 2020

Scientist proposes geroprotective strategies to reduce lethality of COVID-19 in the elderly

The Biogerontology Research Foundation, a registered UK charity supporting and promoting aging and longevity research worldwide since 2008, today announced the publication of a paper titled "Geroprotective and senoremediative strategies to reduce the comorbidity, infection rates, severity, and lethality in gerophilic and gerolavic infections" in the leading journal Aging.

6 Apr 2020

Natural approaches along with current therapies could improve colon cancer treatment

Using a modified natural substance along with current approaches could improve colon cancer treatment, according to findings by University of California, Irvine biologists.

6 Apr 2020

Extracellular forces regulate the formation of epithelia-integrating actomyosin bundles

Different surfaces and organs of the body are covered by epithelial tissue, which is composed of cells tightly connected to each other.

2 Apr 2020

Lipid aids healing of scratches on the cornea

A species of a lipid that naturally helps skin injuries heal appears to also aid repair of common corneal injuries, even when other conditions, like diabetes, make healing difficult, scientists report.

26 Mar 2020

Researchers uncover molecular link between trans fats and variety of disorders

Tohoku University researchers in Japan have uncovered a molecular link between some trans fats and a variety of disorders, including cardiovascular and neurodegenerative diseases.

25 Mar 2020

Research demonstrates control mechanism of force-induced cell-to-cell attachment

Using the amphibian Xenopus laevis as a model, Drs. Noriyuki Kinoshita and Naoto Ueno from the National Institute for Basic Biology, Japan and Dr. Ileana Cristea from Princeton University, USA have demonstrated that physical forces, such as centrifugal force, enhance cell-to-cell attachment and increase the stiffness of embryonic tissues as a result of force-induced cell shape change.

18 Mar 2020

Drug from scorpion venom could offer hope for children with fetal alcohol spectrum disorder

A research team led by Children's National Hospital faculty was able to "rescue" a pre-clinical model of fetal alcohol spectrum disorder in juvenile models, reversing motor skill deficits with the help of a novel drug derived from scorpion venom.

18 Mar 2020

Protective brain-cell housekeeping mechanism may also be involved in regulating sleep

An important biological mechanism that is thought to protect brain cells from neurodegenerative diseases such as Alzheimer's and Parkinson's may also be involved in regulating sleep, according to new research from the Perelman School of Medicine at the University of Pennsylvania.

12 Mar 2020

Gut bacteria can accumulate in tumors and improve effectiveness of cancer immunotherapy

Researchers at the University of Texas Southwestern Medical Center and University of Chicago have discovered that bacteria that usually live in the gut can accumulate in tumors and improve the effectiveness of immunotherapy in mice.

10 Mar 2020

Gut bacteria can boost effectiveness of cancer immunotherapy, mice study suggests

Could the response to cancer immunotherapy depend on bacteria that originate in the gut and travel to the tumor?

7 Mar 2020

Study provides new insight into neurofibromin-deficient ER+ breast cancer

An international team of researchers led by scientists at Baylor College of Medicine has new insights into the function of neurofibromin, a tumor suppressor produced by the NF1 gene.

5 Mar 2020

Study identifies a protein and signaling pathway that may contribute to sudden cardiac death

By studying the sick hearts removed from four patients undergoing heart transplants, researchers have identified a protein and a signaling pathway that may contribute to sudden death in an inherited form of heart disease.

3 Mar 2020

Major investment can help improve technology aimed at turning bad fat to good fat

A significant investment from a Purdue University alumnus and his wife will help further develop technology aimed at treating obesity and diabetes by turning bad fat into good fat inside the body.

28 Feb 2020

New study expands the knowledge on tumor-suppressor role of HERC proteins

The RAF protein could be a therapeutical target to treat the tumor growth in regulated pathways by the p38 protein, according to a new study published in the journal Scientific Reports by a team of experts of the Faculty of Medicine and Health Sciences of the University of Barcelona and the Bellvitge Institute for Biomedical Research.

20 Feb 2020

Signaling Pathway News and Research

Study shows why MDS cells have a competitive advantage that supports disease progression

Tumors commandeer cell death pathway to avoid immune system attack after radiation

Molecular pathway responsible for TNBC's progression and spread identified

Scientist proposes geroprotective strategies to reduce lethality of COVID-19 in the elderly

Natural approaches along with current therapies could improve colon cancer treatment

Extracellular forces regulate the formation of epithelia-integrating actomyosin bundles

Lipid aids healing of scratches on the cornea

Researchers uncover molecular link between trans fats and variety of disorders

Research demonstrates control mechanism of force-induced cell-to-cell attachment

Drug from scorpion venom could offer hope for children with fetal alcohol spectrum disorder

Protective brain-cell housekeeping mechanism may also be involved in regulating sleep

Gut bacteria can accumulate in tumors and improve effectiveness of cancer immunotherapy

Gut bacteria can boost effectiveness of cancer immunotherapy, mice study suggests

Study provides new insight into neurofibromin-deficient ER+ breast cancer

Study identifies a protein and signaling pathway that may contribute to sudden cardiac death

Major investment can help improve technology aimed at turning bad fat to good fat

New study expands the knowledge on tumor-suppressor role of HERC proteins

UCLA researchers identify new molecule that promotes airway health

Breakthrough discovery could open up new treatments for some blood cancers

Study provides a detailed molecular snapshot of endometrial cancer

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