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Researchers develop ferritin-based nanomedicine for targeted delivery of leukemia therapy

Researchers from the Institute of Process Engineering\ of the Chinese Academy of Sciences, Peking University and Zhujiang Hospital of Southern Medical University have developed a ferritin (Fn)-based nanomedicine for targeted delivery of arsenic (As) and efficient therapy against diverse leukemia types.

25 Oct 2021

Regulating blood insulin levels in obese, diabetic patients may help reduce COVID-19 risk

Keeping blood insulin levels within strict, healthy parameters is a daily goal for people with diabetes. But now, researchers from Japan have found that regulating blood insulin levels may even help lower the risk of getting COVID-19.

25 Oct 2021

Can targeting autophagy become a new approach to COVID-19 treatment?

In a recent review, the author discusses autophagy as a contributing mechanism of selected drugs that are currently being evaluated to treat COVID‐19.

25 Oct 2021

Study finds FDA-approved drug has potent antiviral activity against SARS-CoV-2 and variants of concern

A new study aimed to examine the antiviral potential of atovaquone against the original SARS-CoV-2 strain and other variants of concern.

25 Oct 2021

Blood pressure drug increases SARS-CoV-2 receptors in transmission and pathogenesis associated tissues

A new study aimed to determine whether ACE2 targeting drugs change the tissue levels of ACE2 in healthy mice.

25 Oct 2021

Nanoparticle-mediated, slow-release delivery of TT-10 enhances heart attack recovery in mouse model

A heart attack kills heart muscle cells, leading to a scar that weakens the heart, often leading to eventual heart failure. The lack of muscle repair is due to the very limited ability of mammalian heart muscle cells to proliferate, except for a brief period around birth.

25 Oct 2021

Cancer patients have impaired antibody responses to COVID-19 mRNA vaccines

A new study posted to the medRxiv* preprint server studies the neutralizing antibody response in cancer patients diagnosed with chronic lymphocytic leukemia (CLL), lung cancer, breast cancer, and various non-Hodgkin’s lymphomas (NHL), post-reception of two doses of messenger RNA (mRNA) vaccines.

25 Oct 2021

Molecular mechanism that controls the transition from acute to chronic pain revealed

A new study led by University of California, Irvine researchers is the first to reveal the specific molecular mechanism that controls the transition from acute to chronic pain, and identifies this mechanism as a critical target for disease-modifying medicines.

25 Oct 2021

Innovative in vitro platform to evaluate the cardiotoxicity of chemicals

People are continuously exposed to a huge amount and variety of potentially toxic chemicals present in the surrounding environment, such as pesticides or drugs traces in water, soil, air and living organisms. The combined action of pollutants can increase the risk of toxic effects.

25 Oct 2021

Researchers unravel the molecular origins of recombination in RNA viruses

An international consortium, led by Delft University of Technology and the University of North Carolina, has for the first time succeeded in probing the molecular origins of recombination in RNA viruses.

22 Oct 2021

Researchers identify mechanism behind insufficient treatment efficacy of psoriasis drugs

Interleukin-12 - a messenger molecule of immune cells - was long considered to trigger the development of psoriasis.

22 Oct 2021

Researchers find a new way to analyze diseased and healthy cells from brain tumor patients

Scientists studying the most common and aggressive type of brain tumor in adults have discovered a new way of analyzing diseased and healthy cells from the same patient.

22 Oct 2021

New AI-based tool helps clinicians understand and better predict adverse effects of COVID-19

The symptoms and side effects of Covid-19 are scattered across a diagnostic spectrum. Some patients are asymptomatic or experience a mild immune response, while others report significant long-term illnesses, lasting complications, or suffer fatal outcomes.

22 Oct 2021

Targeted drug shows promising activity in kidney cancer patients with brain metastases

A targeted drug has shown promising activity against brain metastases resulting from kidney cancer, achieving a 50 percent response rate, and supporting further studies of the drug in this patient group whose poor prognosis has created a significant unmet need.

21 Oct 2021

Researchers identify a common gene variant that drives the efficiency and outcome of dialysis

Every day, the human kidneys clean about 1,500 liters of blood by producing approximately 1–2 liters of urine. Thereby, the body gets rid of excess water and toxic waste products of the metabolism or also drugs and maintains the balance of water and minerals in the tissues.

21 Oct 2021

Novel Einstein-developed strategy successfully suppresses HIV infections in mice

Armed with a novel strategy they developed for bolstering the body's immune response, scientists at Albert Einstein College of Medicine have successfully suppressed HIV infections in mice - offering a path to a functional cure for HIV and other chronic viral infections.

21 Oct 2021

CAR-T cell treatment's efficacy in hematological malignancies predicted by epigenetics

One in five cancers affects blood cells and lymph nodes, causing leukemias and lymphomas, respectively. Although their treatment with drugs has led to a great advance in their cure, there are cases where there is no clinical response or resistance to them is generated.

21 Oct 2021

Antidepressant Prozac could offer the first treatment for atrophic macular degeneration

An antidepressant best known as Prozac could offer the first treatment for the leading cause of blindness among people over 50, new research from the University of Virginia School of Medicine suggests.

21 Oct 2021

Study highlights major role of polysubstance use in drug overdose risk

Even as the opioid epidemic dominated national attention over the past decade, the rate of overdose deaths involving cocaine, methamphetamine and other stimulants tripled, a new study in veterans suggests.

21 Oct 2021

Researchers employ novel algorithm to identify candidate cancer drugs for pulmonary hypertension

By combining computational and experimental approaches, University of Pittsburgh School of Medicine and Prairie View A&M University researchers identified cancer drugs that show promise for treating pulmonary hypertension, or PH, a rare and incurable lung disease.

21 Oct 2021

Drugs News and Research

Researchers develop ferritin-based nanomedicine for targeted delivery of leukemia therapy

Regulating blood insulin levels in obese, diabetic patients may help reduce COVID-19 risk

Can targeting autophagy become a new approach to COVID-19 treatment?

Study finds FDA-approved drug has potent antiviral activity against SARS-CoV-2 and variants of concern

Blood pressure drug increases SARS-CoV-2 receptors in transmission and pathogenesis associated tissues

Nanoparticle-mediated, slow-release delivery of TT-10 enhances heart attack recovery in mouse model

Cancer patients have impaired antibody responses to COVID-19 mRNA vaccines

Molecular mechanism that controls the transition from acute to chronic pain revealed

Innovative in vitro platform to evaluate the cardiotoxicity of chemicals

Researchers unravel the molecular origins of recombination in RNA viruses

Researchers identify mechanism behind insufficient treatment efficacy of psoriasis drugs

Researchers find a new way to analyze diseased and healthy cells from brain tumor patients

New AI-based tool helps clinicians understand and better predict adverse effects of COVID-19

Targeted drug shows promising activity in kidney cancer patients with brain metastases

Researchers identify a common gene variant that drives the efficiency and outcome of dialysis

Novel Einstein-developed strategy successfully suppresses HIV infections in mice

CAR-T cell treatment's efficacy in hematological malignancies predicted by epigenetics

Antidepressant Prozac could offer the first treatment for atrophic macular degeneration

Study highlights major role of polysubstance use in drug overdose risk

Researchers employ novel algorithm to identify candidate cancer drugs for pulmonary hypertension

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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