Therapy News and Research

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Mitral annulus calcification is a predictor of mortality and a marker of valvular, cardiovascular disease

A retrospective review of more than 24,000 patients who underwent an EKG at Mayo Clinic finds that nearly one-quarter of the patients had mitral annulus calcification, a chronic degeneration of tissue at the base of the heart's mitral valve.

2 Jun 2022

The effectiveness of nirmatrelvir therapy for preventing mortality and hospitalizations due to COVID-19 in high-risk patients during the Omicron surge

Researchers evaluated how effective nirmatrelvir is in preventing COVID-19-associated death and hospitalization in high-risk patients.

2 Jun 2022

New "masked" version of immunotherapy could help fight cancer without causing side effects

Many cancer treatments are notoriously savage on the body; they attack healthy cells at the same time as tumor cells, causing a plethora of side effects.

1 Jun 2022

Membrane lipid stops stress reactions and inhibits cell death

Programmed cell death is an important tool that an organism uses to keep itself healthy. When a cell does not function as it should, various stress reactions are activated. The goal of these reactions is to restore the original cell function.

1 Jun 2022

Genetically modified herpes virus can be used in the fight against cancer

Viruses can make animals and humans sick - or healthy: Researchers at the Fraunhofer Institute for Interfacial Engineering and Biotechnology IGB have succeeded in genetically modifying the herpes simplex virus type 1, which triggers painful cold sores, in such a way that it can be used in the fight against cancer in the future.

1 Jun 2022

Combination bNAb therapy may offer a future alternative to daily ART for people living with HIV

Individuals with HIV who began taking antiretroviral therapy (ART) in the early stages of infection achieved a lengthy period of HIV suppression without ART after receiving two broadly neutralizing anti-HIV antibodies (bNAbs), according to a small study published today in the journal Nature.

1 Jun 2022

Gene therapy for degenerative retinal disease has no safety concerns but fails to improve vision loss

A 28-patient phase 1 gene therapy clinical trial for the degenerative retinal disease Leber hereditary optic neuropathy (LHON) found no significant safety concerns; however, treatment failed to improve or slow vision loss, with even the highest dose. LHON affects the optic nerve, which carries visual signals from the light-sensing retina to the brain.

1 Jun 2022

UCLA researchers identify a method to make tumors susceptible to immune attack

One powerful way cancer cells defend against tumor-killing immune cells is to load up their cell surface with a protein known as PD-L1. Now a team of UCLA Jonsson Comprehensive Cancer Center researchers led by Roger S. Lo, MD, PhD, has identified a method to degrade tumor cell-surface PD-L1, thereby making tumors susceptible to immune attack.

31 May 2022

Liver4Life research team treated damaged liver in a machine and then implanted the recovered organ

The multidisciplinary Zurich research team Liver4Life has succeeded in doing something during a treatment attempt that had never been achieved in the history of medicine until now: it treated an originally damaged human liver in a machine for three days outside a body and then implanted the recovered organ into a cancer patient.

31 May 2022

A multi-pronged effort needed to ensure all patients with obesity get better care

When a person with diabetes, high blood pressure, or osteoarthritis goes to their primary care clinic, they expect treatment that's grounded in modern medical evidence.

31 May 2022

New class of antibiotics found to be highly effective against drug-resistant tuberculosis

Infection by Mycobacterium tuberculosis kills 1.5 million people worldwide every year. Antibiotics to treat TB exist, but in recent years, multi-drug resistant (MDR), extensively drug-resistant (XDR) and totally drug-resistant (TDR) strains of the bacterium have developed.

31 May 2022

Study: Pulse oximeter devices overestimated blood oxygen levels in non-White patients with COVID-19

A retrospective analysis of over 7,000 patients with COVID-19 found that pulse oximeter devices — tools that measure oxygen levels in the blood and that are used in virtually every U.S. hospital — overestimated blood oxygen levels in non-White patients.

31 May 2022

New androgen biosynthesis inhibitor drug for prostate cancer shows mixed results

A new androgen biosynthesis inhibitor drug improved progression-free survival in prostate cancer but did not improve overall survival compared to current therapies, according to a study published in the Journal of Clinical Oncology.

31 May 2022

The effectiveness of tixagevimab/cilgavimab for prevention of SARS-CoV-2 infection and severe disease among immunocompromised patients

A recent article assessed the potency of tixagevimab/cilgavimab in averting SARS-CoV-2 infection in vaccinated immunocompromised people.

31 May 2022

New digital tool provides effective support for the treatment of pediatric obesity

A mobile app that shows a child's weight development in real-time for children with obesity provides greater weight loss compared to conventional care.

31 May 2022

New discovery could pave the way for more effective cancer immunotherapy

A type of white blood cell previously known only as a helper in the immune system appears also to be the instigator of the body's defenses against cancerous tumors.

31 May 2022

Got long covid? Medical expertise is vital, and seniors should prepare to go slow

Older adults who have survived covid-19 are more likely than younger patients to have persistent symptoms such as fatigue, breathlessness, muscle aches, heart palpitations, headaches, joint pain, and difficulty with memory and concentration — problems linked to long covid.

31 May 2022

New compounds for cancer immunotherapy via STING-mediated immune activation

Innovations in cancer immunotherapy have achieved clinical success by considerably increasing the survival rate of patients undergoing cancer treatment.

31 May 2022

Vitamin D therapy may be a useful addition to the treatment of ovarian cancer, study suggests

Ovarian cancer has one of the highest death rates of all cancers. One reason for this is that cancer turns the body's defenses against itself. However, new research from Nagoya University published in Matrix Biology suggests that vitamin D can effectively prevent one of the key pathways used by this cancer.

30 May 2022

Discovery explains why patients with severe asthma are unresponsive to treatment

Patients with the most severe form of asthma produce special substances in their airways when taking medicine during an asthma attack that block the treatment from working, according to a study where Rutgers scientists collaborated with researchers at Genentech, a member of the Roche Group.

30 May 2022

Therapy News and Research

Mitral annulus calcification is a predictor of mortality and a marker of valvular, cardiovascular disease

The effectiveness of nirmatrelvir therapy for preventing mortality and hospitalizations due to COVID-19 in high-risk patients during the Omicron surge

New "masked" version of immunotherapy could help fight cancer without causing side effects

Membrane lipid stops stress reactions and inhibits cell death

Genetically modified herpes virus can be used in the fight against cancer

Combination bNAb therapy may offer a future alternative to daily ART for people living with HIV

Gene therapy for degenerative retinal disease has no safety concerns but fails to improve vision loss

UCLA researchers identify a method to make tumors susceptible to immune attack

Liver4Life research team treated damaged liver in a machine and then implanted the recovered organ

A multi-pronged effort needed to ensure all patients with obesity get better care

New class of antibiotics found to be highly effective against drug-resistant tuberculosis

Study: Pulse oximeter devices overestimated blood oxygen levels in non-White patients with COVID-19

New androgen biosynthesis inhibitor drug for prostate cancer shows mixed results

The effectiveness of tixagevimab/cilgavimab for prevention of SARS-CoV-2 infection and severe disease among immunocompromised patients

New digital tool provides effective support for the treatment of pediatric obesity

New discovery could pave the way for more effective cancer immunotherapy

Got long covid? Medical expertise is vital, and seniors should prepare to go slow

New compounds for cancer immunotherapy via STING-mediated immune activation

Vitamin D therapy may be a useful addition to the treatment of ovarian cancer, study suggests

Discovery explains why patients with severe asthma are unresponsive to treatment

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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