Oxygen News and Research

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Cancer biology, pharmacology and engineering combine to create cancer smart bomb

Imagine a cancer drug that can burrow into a tumor, seal the exits and detonate a lethal dose of anti-cancer toxins, all while leaving healthy cells unscathed.

27 Jul 2005

After 30 aerobic fitness declines rapidly

As if you did you didn't already know, without a team of scientists telling you, your physical fitness is on the decline once you hit 30, but now, even more depressingly for the grey brigade of fitness fanatics out, a new study shows that the decline gains speed with each decade, regardless of a person's previous exercise habits.

27 Jul 2005

Single prenatal dose of methamphetamine enough to cause long-term neurodevelopmental problems in babies

In research published in the August issue of Free Radical Biology and Medicine, U of T pharmacy and pharmacology professor Peter Wells and his colleagues determined that exposing pregnant mice only once to methamphetamine led to delivery of offspring with long-term neurodevelopmental problems, including reduced motor co-ordination.

26 Jul 2005

Leg strength gets a push from training technique

A pair of studies published recently in Medicine & Science in Sports & Exercise (MSSE), the official scientific journal of the American College of Sports Medicine (ACSM), underscore the relevance of sports and exercise research to this year’s Tour de France. One study accurately predicted Lance Armstrong’s time in a stage of the 2004 race, while another points to an effective training technique for aspiring cyclists.

26 Jul 2005

Researchers discover type of "fuel" that the heart uses can contribute to the severity of heart failures

Researchers have determined how metabolic pathways differ between healthy and failing hearts. Normally, a heart derives its energy from a balance of fatty acids and carbohydrates, specifically glucose.

21 Jul 2005

New way to fight antibiotic-resistant Staphylococcus infections

Researchers at the University of California, San Diego School of Medicine and Children’s Hospital and Health Center, San Diego have discovered that "Staph" bacteria use a protective golden armor to ward off the immune system, a finding with the potential to lead to new treatments for serious infections now increasingly resistant to standard antibiotics.

19 Jul 2005

New and more efficient target for antiangiogenic therapy

Scientists now have a more complete understanding of how cancer cells send signals to surrounding tissues to promote development of the blood supply needed to support tumor growth.

19 Jul 2005

Many paramedics do not get enough clinical experience in insertion of emergency breathing tubes

Across the United States, many patients require insertion of emergency breathing tubes before arriving to a hospital, but emergency medicine researchers at the University of Pittsburgh School of Medicine have found that many paramedics - the highest level of prehospital providers - do not get enough clinical experience in this life-saving skill.

19 Jul 2005

New theory on aging says popping pills and drinking orange juice no guarantee you'll live longer

In direct contrast to previous reports, researchers now say that drinking gallons of orange juice and popping vitamin pills may not be a guarantee that you will live longer.

18 Jul 2005

Study shows mutation in NOTCH1 gene causes aortic valve disease

By studying five generations of a Dallas family, UT Southwestern Medical Center researchers have discovered that a mutation in a key gene causes aortic valve disease, a common heart birth defect as well as a major contributor to adult heart disease.

18 Jul 2005

New molecular insights may one day lead to opportunities to stave off old age

Delving deep into the molecular subtleties of a strain of mice engineered to age rapidly, scientists have found that an accumulation of genetic mutations prompts a cascade of programmed cell death that seems to underpin the aging process.

18 Jul 2005

New insights into brain cell metabolism from PET and MRI scans

By discovering a crucial piece of submicroscopic information about how the brain converts fuel into energy for neurons, Cornell University biophysicists have gleaned new insights into brain cell metabolism that will allow neurologists to better interpret data from such diagnostic tests as positron emission tomography (PET) scans and a specialized magnetic resonance imaging (MRI) test.

12 Jul 2005

Congenital central hypoventilation syndrome (CCHS) offers clues to SIDS, sleep apnea

Imagine raising a child who stops breathing when falling asleep - and has to be reminded to visit the bathroom after drinking a Big Gulp. That's the dilemma faced by parents of children born with congenital central hypoventilation syndrome (CCHS).

11 Jul 2005

Giving oxygen may do more harm than good

Doctors and paramedics who give their patients oxygen - the most commonly administered "drug" in the world - may be doing more harm than good, a Queen's University researcher contends.

11 Jul 2005

Study is the first to show that there are mechanisms in place for the immune system to identify cancer cells

A study undertaken by biologists at the University of California, Berkeley, has found that damage to a cell's DNA sets off a chain reaction that leads to the increased expression of a marker recognized by the body's immune system.

6 Jul 2005

Cancer cells may be able to avoid destruction by anti-vascular and anti-angiogenesis agents

Cancer cells may be able to avoid destruction by anti-vascular and anti-angiogenesis agents through a cellular stress response that activates a pro-survival protein called GRP78, according to researchers from the Keck School of Medicine of the University of Southern California.

6 Jul 2005

HIF-1alpha expression regulates the bactericidal capacity of phagocytes

When microorganisms invade the body, immune mechanisms kick in to fight them off. The infected tissues typically show depleted oxygen levels, and a protein called HIF-1 alpha regulates this. Interestingly, the cells responsible for destroying the foreign pathogens are effective in this low-oxygen environment.

6 Jul 2005

Disruption of a single gene, Nrf2, plays a critical role in determining the susceptibility to asthma

A research team led by Shyam Biswal , PhD, at the Johns Hopkins Bloomberg School of Public Health found the absence of Nrf2 exacerbated allergen-mediated asthma in mice models.

5 Jul 2005

Children who snore are far more likely to suffer hyperactivity disorders

Several years ago, University of Michigan researchers published some of the strongest evidence yet that children who snore when they sleep are far more likely to have attention and hyperactivity problems than their non-snoring peers.

4 Jul 2005

Scientists discover identifying markers for primitive blood-forming stem cells - simplifies cell identification

Scientists at the University of Michigan Medical School have discovered the biological equivalent of a grocery store bar code on the surface of primitive, blood-forming stem cells in mice. Called hematopoietic stem cells, they give rise to all the different types of specialized cells found in blood.

30 Jun 2005

Oxygen News and Research

Cancer biology, pharmacology and engineering combine to create cancer smart bomb

After 30 aerobic fitness declines rapidly

Single prenatal dose of methamphetamine enough to cause long-term neurodevelopmental problems in babies

Leg strength gets a push from training technique

Researchers discover type of "fuel" that the heart uses can contribute to the severity of heart failures

New way to fight antibiotic-resistant Staphylococcus infections

New and more efficient target for antiangiogenic therapy

Many paramedics do not get enough clinical experience in insertion of emergency breathing tubes

New theory on aging says popping pills and drinking orange juice no guarantee you'll live longer

Study shows mutation in NOTCH1 gene causes aortic valve disease

New molecular insights may one day lead to opportunities to stave off old age

New insights into brain cell metabolism from PET and MRI scans

Congenital central hypoventilation syndrome (CCHS) offers clues to SIDS, sleep apnea

Giving oxygen may do more harm than good

Study is the first to show that there are mechanisms in place for the immune system to identify cancer cells

Cancer cells may be able to avoid destruction by anti-vascular and anti-angiogenesis agents

HIF-1alpha expression regulates the bactericidal capacity of phagocytes

Disruption of a single gene, Nrf2, plays a critical role in determining the susceptibility to asthma

Children who snore are far more likely to suffer hyperactivity disorders

Scientists discover identifying markers for primitive blood-forming stem cells - simplifies cell identification

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