Antigen News and Research

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Reviving reservoirs: new findings shake up HIV treatment understanding

Researchers provide insight into the interaction between T lymphocytes and persisting reservoirs of HIV, with repercussions for harnessing effective, long-lasting responses to HIV eradication.

14 Sep 2023

A novel multi-epitope vaccine targeting extracellular proteins of Chlamydia pneumoniae

Researchers designed and evaluated a multi-epitope vaccine targeting the main outer membrane protein of Chlamydia pneumoniae using immunoinformatics.

14 Sep 2023

Oral SARS-CoV-2 vaccine shows promise in monkeys

A new paper in Biology Methods and Protocols, published by Oxford University Press, indicates that researchers studying SARS-CoV-2 may have developed new methods to administer vaccines orally, which would be both easier to administer and more effective at combatting illnesses.

13 Sep 2023

COVID-19 doubles risk of early type 1 diabetes signs in high-risk children

New research in JAMA finds a temporal association between SARS-CoV-2 infections and the onset of islet autoimmunity, a precursor to type 1 diabetes, in genetically predisposed infants. The study underscores COVID-19 as a potential risk factor for the development of this form of diabetes in young children.

13 Sep 2023

“Inverse vaccine” shows promise to reverse autoimmune diseases without shutting down rest of the immune system

A new type of vaccine developed by researchers at the University of Chicago's Pritzker School of Molecular Engineering (PME) has shown in the lab setting that it can completely reverse autoimmune diseases like multiple sclerosis, type 1 diabetes, and Crohn's disease - all without shutting down the rest of the immune system.

12 Sep 2023

The safety and efficacy of the nano-based COVID-19 vaccine

A recent study evaluated the safety and efficacy of the GBP510 vaccine against SARS-CoV-2 infection.

12 Sep 2023

New machine-learning algorithms can help optimize the next-generation of therapeutic antibodies

Antibody treatments may be able to activate the immune system to fight diseases like Parkinson’s, Alzheimer’s and colorectal cancer, but they are less effective when they bind with themselves and other molecules that aren’t markers of disease.

11 Sep 2023

Unlocking the secrets of our body's first line of defense against strep throat and more

Researchers have mapped the complex structures of secretory immunoglobulin A (sIgA) in interaction with human CD89 and Streptococcus pyogenes M4, offering new insights into how our first line of mucosal defense operates. The study reveals the intricate ways these components may influence each other, impacting both bacterial survival strategies and host immune responses.

10 Sep 2023

New way to administer CAR-T-cell therapy could lead to fewer side effects

When Richard O'Neil, Ph.D., joined MUSC Hollings Cancer Center two years ago, he knew that he wanted to continue finding ways to make CAR-T-cell therapy easier on patients.

8 Sep 2023

Self-adjuvanting RNA vaccines boost immune response 10x more than existing vaccines

RNA vaccines against Covid-19 have proven effective at reducing the severity of disease. However, a team of researchers at MIT is working on making them even better.

8 Sep 2023

Scientists discover thymic M cells

It came as a surprise to Professor David Lo and his graduate student Diana Del Castillo when they were recently consulted by researchers in Israel for their expertise on specialized cells called Microfold cells, or M cells, which are mostly known for their presence in the intestinal epithelium.

7 Sep 2023

Immune cells can create their own chemical cues to navigate in complex environments

Human immune cells are capable of coordinating their own movement more independently than previously thought. InFLAMES researcher Jonna Alanko has discovered that immune cells do not just passively follow the chemical cues in their environment.

7 Sep 2023

Novavax's updated XBB.1.5 vaccine shows promising cross-neutralizing antibodies against new COVID-19 variants

The study reveals that Novavax's updated XBB.1.5 vaccine effectively induces cross-neutralizing antibodies against multiple Omicron XBB sub-variants in both mice and non-human primates.

5 Sep 2023

Boosters slow antibody waning but hit a ceiling: Long-term COVID study reveals limits of immunity

The study tracks the long-term kinetics of antibody responses to SARS-CoV-2 after vaccination and infections in New York healthcare workers from 2020 to 2023. It reveals that antibody waning is slower after booster shots, but there's an upper limit to antibody levels, which gradually lowers with repeated SARS-CoV-2 exposures and vaccinations.

31 Aug 2023

Fourth COVID-19 booster supercharges antibody defense in older adults, study says

The study finds that the fourth dose of the COVID-19 mRNA vaccine significantly boosts neutralizing antibody levels in the elderly, providing enhanced protection against new SARS-CoV-2 variants like Omicron. This supports the efficacy of booster shots for older populations in combating COVID-19.

31 Aug 2023

Gene variant protects against Alzheimer's and Parkinson's diseases

About one in every five people carries a version of a gene that, although largely unsung, appears to confer protection against both Alzheimer's disease and Parkinson's disease, Stanford Medicine investigators and their colleagues have learned.

30 Aug 2023

New oral agent shows promise in treatment of relapsed multiple myeloma

A new agent that subverts myeloma cells from within while also subjecting them to an immune system attack produced impressive responses in combination with dexamethasone in patients with multiple myeloma that had relapsed and stopped responding to all currently available therapies, a clinical trial conducted by researchers at Dana-Farber Cancer Institute and around the world has found.

30 Aug 2023

GADx's BotrytisAlert now detects fungal crop pathogen across several critical points in wine production

Global Access Diagnostics (GADx), a social enterprise and leading developer of lateral flow and rapid diagnostic technologies, today announced it has expanded the applications of its low-cost, rapid diagnostic test, BotrytisAlert.

From Global Access Diagnostics 30 Aug 2023

Can muvalaplin achieve safe and tolerable plasma concentrations adequate to reduce steady-state Lp(a) levels without modulating plasminogen activity in humans?

Researchers evaluated the tolerability, safety, pharmacodynamics, and pharmacokinetic properties of muvalaplin.

30 Aug 2023

How frequent are hospital-onset SARS-CoV-2 infections and what hospital characteristics are associated with rates of hospital-onset SARS-CoV-2 infections?

Researchers investigated the frequency of hospital-onset COVID-19 cases and the hospital characteristics related to hospital-onset infections by SARS-CoV-2 in US.

30 Aug 2023

Antigen News and Research

Reviving reservoirs: new findings shake up HIV treatment understanding

A novel multi-epitope vaccine targeting extracellular proteins of Chlamydia pneumoniae

Oral SARS-CoV-2 vaccine shows promise in monkeys

COVID-19 doubles risk of early type 1 diabetes signs in high-risk children

“Inverse vaccine” shows promise to reverse autoimmune diseases without shutting down rest of the immune system

The safety and efficacy of the nano-based COVID-19 vaccine

New machine-learning algorithms can help optimize the next-generation of therapeutic antibodies

Unlocking the secrets of our body's first line of defense against strep throat and more

New way to administer CAR-T-cell therapy could lead to fewer side effects

Self-adjuvanting RNA vaccines boost immune response 10x more than existing vaccines

Scientists discover thymic M cells

Immune cells can create their own chemical cues to navigate in complex environments

Novavax's updated XBB.1.5 vaccine shows promising cross-neutralizing antibodies against new COVID-19 variants

Boosters slow antibody waning but hit a ceiling: Long-term COVID study reveals limits of immunity

Fourth COVID-19 booster supercharges antibody defense in older adults, study says

Gene variant protects against Alzheimer's and Parkinson's diseases

New oral agent shows promise in treatment of relapsed multiple myeloma

GADx's BotrytisAlert now detects fungal crop pathogen across several critical points in wine production

Can muvalaplin achieve safe and tolerable plasma concentrations adequate to reduce steady-state Lp(a) levels without modulating plasminogen activity in humans?

How frequent are hospital-onset SARS-CoV-2 infections and what hospital characteristics are associated with rates of hospital-onset SARS-CoV-2 infections?

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