DNA Sequencing News and Research

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Studying Tumor Mutations Via A Network Approach

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16 Sep 2013

Domestic animals less likely to be major source of antibiotic resistant Salmonella in humans

A new study has shown that, contrary to popular belief, local domestic animals are unlikely to be the major source of antibiotic resistant Salmonella in humans. The result comes from a detailed study of DNA from more than 370 Salmonella samples collected over a 22-year period.

13 Sep 2013

Data can help scientists, physicians match precision drugs to cancer's genetic traits

More than 5,000 genetic profiles of tumor DNA have been completed in a large research study by scientists at Dana-Farber Cancer Institute, Brigham and Women's Hospital, and Boston Children's Hospital designed to speed the development of personalized cancer care with precision treatments.

13 Sep 2013

Study shows anorexia linked to how cholesterol processes

The largest DNA-sequencing study of anorexia nervosa has linked the eating disorder to variants in a gene coding for an enzyme that regulates cholesterol metabolism. The finding suggests that anorexia could be caused in part by a disruption in the normal processing of cholesterol, which may disrupt mood and eating behavior.

12 Sep 2013

New research explains how DNA strands repair themselves

Researchers have discovered the details of how cells repair breaks in both strands of their DNA, a potentially devastating kind of DNA damage.

12 Sep 2013

Genia Technologies receives $5M grant from NIH to develop nanopore-based DNA sequencing platform

Genia Technologies, Inc. today announced that the company, as part of a research consortium with Columbia University and Harvard Medical School, received a Revolutionary Genome Sequencing Technologies – The $1,000 Genome grant from the National Human Genome Research Institute (NHGRI) of the National Institutes of Health (NIH).

12 Sep 2013

Professor to develop DNA sequencing technologies to search for long-range genome interactions

Why do some people develop disease while others with the same genetic mutation don't? For example, the National Cancer Institute estimates that women who inherit a harmful BRCA2 mutation have a 45 percent chance of developing breast cancer by age 70.

11 Sep 2013

Researchers discover inherited gene mutation linked to childhood leukemia

Researchers have discovered the first inherited gene mutation linked exclusively to acute lymphoblastic leukemia occurring in multiple relatives in individual families. The discovery of the PAX5 gene mutation was led by St. Jude Children's Research Hospital and others. The work appears in the current advance online edition of the scientific journal Nature Genetics.

11 Sep 2013

Three rapid diagnostic tests could be used to diagnose drug resistance in TB

Results of a new study suggest that three new diagnostic tests could each be used to successfully diagnose drug resistance in tuberculosis (TB) patients in a quarter of the time taken by the current method.

10 Sep 2013

Research team receives nearly $17M to focus on nanopore technology in DNA sequencing

The use of nanopore technology aimed at more accurate and efficient DNA sequencing is the main focus of grants awarded by the National Institutes of Health. The grants - nearly $17 million to eight research teams - are the latest awarded through the National Human Genome Research Institute (NHGRI)'s Advanced DNA Sequencing Technology program, which was launched in 2004. NHGRI is part of NIH.

7 Sep 2013

Natural products: The source of nearly half of modern drugs

New technology for discovering antibiotics, anti-cancer drugs and other medicines inside soil microbes and other natural sources is reviving a treasure hunt that already has given humanity more than 50 percent of today's prescription drugs. This new era in "bioprospecting" is the topic of the cover story in Chemical & Engineering News, the weekly newsmagazine of the American Chemical Society.

5 Sep 2013

Researchers discover role played by epigenetic factors in senescence and age-related diseases

One way cells promote tumor suppression is through a process called senescence, an irreversible arrest of proliferation. Senescence is thought to be associated with normal aging, but is also a protective measure by the body against run-away cell replication.

31 Aug 2013

Novel machine learning-based approach used to predict hepatotoxic potential of DNA drug

New classes of therapeutic antisense oligonucleotides can have toxic effects on the liver. A novel machine learning-based approach used to predict the hepatotoxic potential of an antisense drug based on its chemical sequence is presented in Nucleic Acid Therapeutics, a peer-reviewed journal from Mary Ann Liebert, Inc. publishers.

28 Aug 2013

TSRI scientists find way to use new DNA-editing technology for DNA sequencing

Scientists at The Scripps Research Institute have found a way to apply a powerful new DNA-editing technology more broadly than ever before.

27 Aug 2013

Study: Structural defect in skin cells can contribute to allergy development

In a new study published in Nature Genetics, Northwestern Medicine and Tel Aviv University scientists have found that a structural defect in skin cells can contribute to allergy development, including skin and food allergies, traditionally thought primarily to be a dysfunction of the immune system.

27 Aug 2013

Scientists discover crucial role of nitric oxide in cellular signaling and health

Scientists at the University of Illinois at Chicago College of Pharmacy have discovered a new role for nitric oxide, a gas molecule crucial for cellular signaling and health.

26 Aug 2013

Scientists discover that chromosomal rearrangements can be advantageous

In a pioneer study published in the latest issue of the scientific journal Nature Communications, a research team at the Instituto Gulbenkian de Ci-ncia (IGC; Portugal), led by Miguel Godinho Ferreira in collaboration with Isabel Gordo, show for the first time that chromosomes rearrangements (such as inversions or translocations) can provide advantages to the cells that harbor them depending on the environment they are exposed.

23 Aug 2013

Researchers discover 100% genetic match for MERS in insect-eating bat in Saudi Arabia

A 100% genetic match for Middle East Respiratory Syndrome (MERS) has been discovered in an insect-eating bat in close proximity to the first known case of the disease in Saudi Arabia. The discovery points to the likely animal origin for the disease, although researchers say that an intermediary animal is likely also involved.

22 Aug 2013

Researchers provide support for potential importance of vitamin D in pregnancy

Researchers at the MRC Lifecourse Epidemiology Unit, University of Southampton, have demonstrated that the degree to which a gene related to vitamin D action is switched on or off, when measured at birth, predicts bone density of the child at four years of age.

16 Aug 2013

Study suggests that about 70% of total Alzheimer's risk is hereditary

Alzheimer's, and intervene to reduce the risk of the disease? We may be closer to that goal, thanks to a team at the University of Kentucky. Researchers affiliated with the UK Sanders-Brown Center on Aging have completed new work in Alzheimer's genetics; the research is detailed in a paper published today in the Journal of Neuroscience.

16 Aug 2013

DNA Sequencing News and Research

Studying Tumor Mutations Via A Network Approach

Domestic animals less likely to be major source of antibiotic resistant Salmonella in humans

Data can help scientists, physicians match precision drugs to cancer's genetic traits

Study shows anorexia linked to how cholesterol processes

New research explains how DNA strands repair themselves

Genia Technologies receives $5M grant from NIH to develop nanopore-based DNA sequencing platform

Professor to develop DNA sequencing technologies to search for long-range genome interactions

Researchers discover inherited gene mutation linked to childhood leukemia

Three rapid diagnostic tests could be used to diagnose drug resistance in TB

Research team receives nearly $17M to focus on nanopore technology in DNA sequencing

Natural products: The source of nearly half of modern drugs

Researchers discover role played by epigenetic factors in senescence and age-related diseases

Novel machine learning-based approach used to predict hepatotoxic potential of DNA drug

TSRI scientists find way to use new DNA-editing technology for DNA sequencing

Study: Structural defect in skin cells can contribute to allergy development

Scientists discover crucial role of nitric oxide in cellular signaling and health

Scientists discover that chromosomal rearrangements can be advantageous

Researchers discover 100% genetic match for MERS in insect-eating bat in Saudi Arabia

Researchers provide support for potential importance of vitamin D in pregnancy

Study suggests that about 70% of total Alzheimer's risk is hereditary

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