Hematology News and Research

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Hematology, also spelled haematology, is the branch of biology (physiology), pathology, clinical laboratory, internal medicine, and pediatrics that is concerned with the study of blood, the blood-forming organs, and blood diseases. Hematology includes the study of etiology, diagnosis, treatment, prognosis, and prevention of blood diseases.

Effort to control opioids in an ER leaves some sickle cell patients in pain

India Hardy has lived with pain since she was a toddler — ranging from dull persistent aches to acute flare-ups that interrupt the flow of her normal life.

6 Jan 2020

Researchers discover a way to move precision immunotherapy forward for multiple myeloma

Researchers at the Icahn School of Medicine at Mount Sinai have discovered a way to move precision immunotherapy forward by using genomics to inform immunotherapy for multiple myeloma, a blood cancer, according to a study published in Clinical Cancer Research, a journal of the American Association for Cancer Research, in December.

19 Dec 2019

ACCC develops new tools and resources to improve care for geriatric patients with cancer

To prepare the multidisciplinary cancer care team for the growing prevalence of cancer and comorbidities among our nation’s graying population, the Association of Community Cancer Centers—in collaboration with The Gerontological Society of America and the International Society of Geriatric Oncology—has developed new tools and resources, offering expert insights through its Multidisciplinary Approaches to Caring for Geriatric Patients with Cancer program.

18 Dec 2019

New combination therapy can lead to durable responses in patients with multiple myeloma

An experimental, off-the-shelf immunotherapy that combines a targeted antibody and chemotherapy can lead to potentially durable responses in multiple myeloma patients whose disease has relapsed or is resistant to other standard therapies.

17 Dec 2019

Extrachromosomal circular DNA can contribute to cancer development in children

Cancer development is associated with the gradual accumulation of DNA defects over time. Thus, cancer is considered an age-related disease.

17 Dec 2019

Mount Sinai Kravis Children's Hospital receives new grant to support "Paws & Play" program

Mount Sinai Kravis Children's Hospital announced today that PetSmart Charities has offered a gift of $75,000 to extend the tenure of Professor Bunsen Honeydew the hospital's first of three facility dogs, through October 2020.

12 Dec 2019

Researchers develop 'scar in a dish' model to closely mimic progressive organ scarring

Every organ in the body is capable, to some extent, of repairing itself after an injury. As part of this process, scar tissue forms and then recedes to make room for normal tissue when healing is complete.

11 Dec 2019

Clinical trial eligibility criteria may be excessive, needlessly excluding patients

Federal regulations may keep lung cancer patients out of clinical trials simply because these patients are on medications that might affect the electrical system of the heart. Drilling into the details quickly turns up reasons to think these regulations may be preventing a substantial proportion of patients from participating in clinical trials.

10 Dec 2019

Study provides most detailed classification of acute myeloid leukemia, myelodysplastic syndrome

Results from a study conducted by St. Jude Children's Research Hospital and the Munich Leukemia Laboratory were presented today as a late-breaking abstract at the American Society of Hematology annual meeting. The study integrates genomic and transcriptomic sequencing to provide the most detailed classification of acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) to date.

10 Dec 2019

Researchers aim to exploit DNA mutations in the treatment of blood and bone marrow cancers

In a clinical trial led by Yale Cancer Center and Smilow Cancer Hospital, researchers aim to exploit DNA mutations in the treatment of two blood and bone marrow cancers, a different tacit than the more traditional approach of blunting or switching off genetic mutations linked to cancer.

10 Dec 2019

Immunotherapy more effective than chemotherapy for children, young adults with relapsed B-ALL

New findings from a clinical trial show that treatment with the immunotherapy drug blinatumomab is superior to standard chemotherapy for children and young adults with high- or intermediate-risk B-cell acute lymphoblastic leukemia that has relapsed.

10 Dec 2019

Scientists highlight the benefits of Droplet Digital PCR technology at the 2019 ASH meeting

Scientists will present more than 40 abstracts highlighting research driven in part by Bio-Rad Laboratories' Droplet Digital PCR (ddPCR) technology at the 2019 American Society of Hematology (ASH) meeting in Orlando Florida, December 7-10.

10 Dec 2019

Combination therapy is safe and effective for older patients diagnosed with acute lymphoblastic leukemia

A study led by The University of Texas MD Anderson Cancer Center showed that treatment combining lower doses of chemotherapy with the monoclonal antibody inotuzumab ozogamicin (INO), with or without the drug blinatumomab, is safe and effective in patients over 60 years of age who were newly diagnosed with a high-risk form of acute lymphoblastic leukemia (ALL) known as Philadelphia chromosome-negative ALL.

10 Dec 2019

Rutgers researchers identify small mutations for AML and MDS through deep DNA sequencing

Deep DNA sequencing analysis conducted by Rutgers Cancer Institute of New Jersey investigators examining genomic differences within tumors for prediction of disease relapse in certain hematologic malignancies has identified small mutations.

9 Dec 2019

New strategies needed to manage ibrutinib-related toxicities in CLL patients, study suggests

New findings by Yale Cancer Center and Smilow Cancer Hospital researchers show that as the use of the drug ibrutinib climbs in patients with chronic lymphocytic leukemia, so do the rates of patients who stop taking the drug.

9 Dec 2019

Relapsed mantle cell lymphoma patients may benefit from CAR T-cell therapy

A one-year follow-up study led by The University of Texas MD Anderson Cancer Center revealed a majority of patients with mantle cell lymphoma resistant to prior therapies may benefit from treatment with CD19-targeting chimeric antigen receptor (CAR) T-cell therapy.

9 Dec 2019

Stem cell transplant following treatment with PD-1 inhibitor is safe, effective for patients with Hodgkin lymphoma

A new analysis shows that a donor stem cell transplant following treatment with an immune checkpoint inhibitor is generally safe and produces good outcomes for patients with Hodgkin lymphoma, easing concerns that these patients are at heightened risk for severe immune-related complications.

9 Dec 2019

Pairing chemotherapy azacitidine with enasidenib boosts complete remission in AML patients

A multi-institutional, Phase II study led by The University of Texas MD Anderson Cancer Center showed that pairing standard chemotherapy azacitidine (AZA) with a drug called enasidenib (ENA) measurably boosts complete remission in patients newly diagnosed with a specific form of acute myeloid leukemia (AML).

9 Dec 2019

Yale study highlights the need to develop effective, less toxic approaches to treat AML patients

A new study by Yale Cancer Center researchers shows understanding treatment patterns for patients with acute myeloid leukemia is vital to develop strategies to improve outcomes.

9 Dec 2019

Venetoclax in combination with azacytidine aids therapy for myelodysplastic syndromes

A new study by Yale Cancer Center and Smilow Cancer Hospital researchers suggests that the drug venetoclax aids therapy for relapsed/refractory myelodysplastic syndromes, especially when paired with azacytidine.

9 Dec 2019

Hematology News and Research

Further Reading

Effort to control opioids in an ER leaves some sickle cell patients in pain

Researchers discover a way to move precision immunotherapy forward for multiple myeloma

ACCC develops new tools and resources to improve care for geriatric patients with cancer

New combination therapy can lead to durable responses in patients with multiple myeloma

Extrachromosomal circular DNA can contribute to cancer development in children

Mount Sinai Kravis Children's Hospital receives new grant to support "Paws & Play" program

Researchers develop 'scar in a dish' model to closely mimic progressive organ scarring

Clinical trial eligibility criteria may be excessive, needlessly excluding patients

Study provides most detailed classification of acute myeloid leukemia, myelodysplastic syndrome

Researchers aim to exploit DNA mutations in the treatment of blood and bone marrow cancers

Immunotherapy more effective than chemotherapy for children, young adults with relapsed B-ALL

Scientists highlight the benefits of Droplet Digital PCR technology at the 2019 ASH meeting

Combination therapy is safe and effective for older patients diagnosed with acute lymphoblastic leukemia

Rutgers researchers identify small mutations for AML and MDS through deep DNA sequencing

New strategies needed to manage ibrutinib-related toxicities in CLL patients, study suggests

Relapsed mantle cell lymphoma patients may benefit from CAR T-cell therapy

Stem cell transplant following treatment with PD-1 inhibitor is safe, effective for patients with Hodgkin lymphoma

Pairing chemotherapy azacitidine with enasidenib boosts complete remission in AML patients

Yale study highlights the need to develop effective, less toxic approaches to treat AML patients

Venetoclax in combination with azacytidine aids therapy for myelodysplastic syndromes

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