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Age and immunity: study highlights challenges and opportunities for vaccine protection

Scientists have evaluated molecular mechanisms responsible for heterogeneous responses to influenza vaccination among older adults.

17 Jul 2023

Understanding the impact of HPV on the vaginal microbiome and its role in cervical cancer

Researchers determine whether cervical cancer risk could be assessed using microflora-derived metabolites in HPV-infected females.

17 Jul 2023

Aerobic glycolysis essential for eye development in mammals, study finds

Aerobic glycolysis, the process by which cells transform glucose into lactate, is key for eye development in mammals, according to a new Northwestern Medicine study published in Nature Communications.

14 Jul 2023

Exploring the relationship between epigenetic aging and gut microbiome composition in physically fit men and women

Researchers investigate the relationship between the gut microbiome, physical fitness, and epigenetic aging in physically fit individuals.

14 Jul 2023

NOSTER & Science Microbiome Prize winner illuminates how "silent flagellins" from commensal microbiota evade innate immunity

Sara Clasen is the 2023 winner of the NOSTER & Science Microbiome Prize for her work in illuminating how "silent flagellins" from commensal microbiota evade a host's innate immunity.

6 Jul 2023

New blood test could diagnose bile acid diarrhea

Most people have at some point in their life suffered an intestinal infection or food poisoning forcing them to stay close to the bathroom. It is very uncomfortable. Most of the time, though, it passes quickly.

5 Jul 2023

Reproductive impact of changes in the vaginal microbiome of obese women

Study explores the impact of obesity on vaginal microbiota and reproduction.

5 Jul 2023

New atlas offers a way to identify the deep mechanisms of cancer

An atlas that catalogs gene activity and the levels of small molecules called metabolites in tumor samples offers a new way of identifying the deep mechanisms of cancer, according to researchers at Weill Cornell Medicine and Memorial Sloan Kettering Cancer Center.

29 Jun 2023

The effect of coffee consumption on abdominal aortic calcification among adults

How coffee consumption affects the incidence of abdominal aortic calcification.

23 Jun 2023

Mapping the by-products of bacteria processing amino acids associated with cardiovascular disease

A Cleveland Clinic research team recently published an "atlas" of metabolites associated with cardiovascular disease in the European Heart Journal. The novel findings provide key details about the routes and potential branching paths taken by bacteria and metabolic by-products, metabolites.

23 Jun 2023

Study reveals contrasting effects of sucralose on insulin and glucose control

Sucralose, a commonly used artificial sweetener, has contrasting effects on insulin secretion and glucose homeostasis. While bolus administration of sucralose enhances insulin secretion and decreases glucose levels, long-term consumption exacerbates insulin resistance and glucose intolerance, particularly in combination with a high-fat diet. The study highlights the involvement of the T1R3-ERK1/2 pathway in sucralose-induced insulin resistance in the liver.

22 Jun 2023

Study reveals how metformin interacts with the liver and gut to reduce circulating glucose levels

There are still many enigmas about the mechanism of action of metformin, the most prescribed drug to treat diabetes mellitus, also known as type 2 diabetes.

22 Jun 2023

Herbal extracts for mental health: Are they safe for pregnant women?

Researchers evaluate the T-cell modulating effects of St. John’s wort, valerian, hops, lavender, and California poppy.

18 Jun 2023

Research explores complex relationship between cholesterol and breast cancer risk

Research explores the complex relationship between cholesterol and breast cancer risk, with some studies suggesting an increased risk with elevated cholesterol levels while others find an inverse association.

15 Jun 2023

Gut microbiota holds clues to predicting Alzheimer's risk

Gut microbiome alterations in preclinical Alzheimer's disease (AD) were investigated, revealing distinct taxonomic composition and potential markers of AD risk. These findings contribute to understanding AD pathology and offer insights into gut-derived markers for AD.

15 Jun 2023

Study reveals impressive skin benefits of blueberries

The benefits of topical and dietary blueberry supplementation in preventing environmental stressor-mediated skin damage and preserving skin health.

14 Jun 2023

Study finds altered gut bacteria in people with early signs of Alzheimer's disease

People in the earliest stage of Alzheimer's disease - after brain changes have begun but before cognitive symptoms become apparent - harbor an assortment of bacteria in their intestines that differs from the gut bacteria of healthy people, according to a study by researchers at Washington University School of Medicine in St. Louis.

14 Jun 2023

CHOP researchers engineer stable, universal MHC-I molecules in a shorter timeframe

Class I major histocompatibility complex (MHC-I) proteins play an essential role in the immune system of all jawed vertebrates. The MHC-I displays peptide fragments of proteins from within the cell on the cell surface, "presenting" them to the immune system, which is constantly scanning the body for foreign or toxic antigens.

13 Jun 2023

Vaccine against deadly chytrid fungus shifts microbiome to make frogs more resilient to future exposure

A human or animal's microbiome - the collection of often beneficial microorganisms, including as bacteria and fungi, that live on or within a host organism - can play an important role in the host's overall immune response, but it is unclear how vaccines against harmful pathogens impact the microbiome.

11 Jun 2023

Sea cucumbers could be key ingredient in preventing diabetes

Sea cucumbers are a marine delicacy loved across Asia, but the humble sea cucumber is also proving to be a key ingredient in preventing diabetes, according to new research from the University of South Australia.

10 Jun 2023