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Research reveals a previously unknown role for a key transcription regulator linked to cancer

CTCF is a transcription factor that has been a research target due to its role in regulating a critical oncogene called MYC.

7 Sep 2021

New low-cost technique helps profile dynamic metabolic features from single isogenic cells

Researchers with the Single-Cell Center, Qingdao Institute of Bioenergy and Bioprocess Technology of the Chinese Academy of Sciences, have developed a fast, low-cost and high-throughput technique capable of profiling dynamic metabolic features from just one isogenic sample of cells.

1 Sep 2021

New compounds offer a two-for-one punch to fight estrogen-sensitive breast cancer

A set of compounds developed by scientists at Scripps Research in Florida target estrogen-sensitive breast cancer cells in new ways, potentially creating better options for patients with treatment-resistant cancers.

31 Aug 2021

Role of glycans on the SARS-CoV-2 spike protein in human receptor interaction

A team of investigators, led by Dr. Benjamin F. Mann, from Merck, USA have published a new study on the preprint server bioRxiv*. They have used a biochemical approach to control the glycosylation profile of the S protein receptor-binding domain (RBD) and to analyze the effect of different glycosylation patterns on receptor binding.

30 Aug 2021

Migraine-inducing peptides may protect against diabetes by influencing insulin production

People who get migraines are less likely to develop type 2 diabetes, while some people who develop diabetes become less prone to migraines.

26 Aug 2021

The influence of COVID-19 on platelet activation and aggregation

In a paper recently uploaded to the bioRxiv* preprint server, humanized ACE2 mice are infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and platelets are subsequently isolated from the blood for quantitative proteomic analysis.

26 Aug 2021

Researchers identify a cluster of small molecules that contribute to coffee's mouthfeel

Coffee drinkers intuitively recognize the pleasure of swallowing a smooth, rich brew versus a watery one.

24 Aug 2021

Study pinpoints an enzyme with a significant impact on SARS-CoV-2 replication

By applying a systems biology approach, a recent bioRxiv* preprint research paper by scientists from the Icahn School of Medicine at Mount Sinai in New York unveils interactions between the severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) and p38 mitogen-activated protein kinase (MAPK) pathway responsible for regulating the expression of crucial inflammatory mediators in human lung epithelial cells.

23 Aug 2021

Northwestern scientists discover remarkable longevity in a subset of mitochondrial proteins

Northwestern Medicine investigators have discovered that a subset of proteins in mitochondria of brain and heart cells are long-lived, supporting the long-term stability of mitochondrial complex architecture.

20 Aug 2021

Studies shed light on the versatility, precision, and sensitivity of quantitative analytical tools

Three independent studies in the Journal of Pharmaceutical Analysis explore the potential uses and applications of quantitative analytical tools in the characterization and quality assessment of biological and medicinal compounds.

19 Aug 2021

How do glycans affect SARS-CoV-2 spike protein openings?

In a paper recently uploaded to the bioRxiv* preprint server, the role of glycan coating on the SARS-CoV-2 spike protein is further investigated by molecular dynamics simulations of the glycosylated and non-glycosylated protein, identifying several key glycans that play a role in stabilizing and protecting the RBD, and also encourage bonding with the ACE2 receptor.

18 Aug 2021

Study uncovers molecular mechanisms that promote cell-to-cell adhesion and communication

A study led by Northwestern Medicine investigators has identified the molecular mechanisms within protein complexes that promote cell-to-cell adhesion and communication, according to findings published in the Proceedings of the National Academy of Sciences.

11 Aug 2021

Scientists develop new approach to identify proteins in the living brain

For the first time, researchers have developed a successful approach for identifying proteins inside different types of neurons in the brain of a living animal.

11 Aug 2021

Emerging biosensing technologies could revolutionize the diagnosis of neonatal sepsis

Sepsis in newborn infants can be fatal. Early diagnosis is thus key to effectively manage the infection. Conventional diagnostic methods are, however, time-consuming.

11 Aug 2021

Research shows how SARS-CoV-2 variants are evolving towards increased furin cleavage efficiency

The spike protein comprises of two subunits: S1 subunit having the receptor-binding domain (RBD) that helps it to bind to the angiotensin-converting enzyme 2 (ACE2), which is present on the cell surface of the host, and the S2 subunit that helps in the fusion of the cellular membrane and the viral membrane.

9 Aug 2021

Could a plant metabolite in liverworts be a potent antiviral against SARS-CoV-2 and other RNA viruses?

A new study from the National Centre for Biotechnology and Medicinal Chemistry Institute suggests Mother Nature delivered — in the form of liverworts. They found that the bryophyte Marchantia polymorpha, also known as umbrella liverworts, could work as a potential antiviral treatment.

5 Aug 2021

New molecular and morphologic insights into chronic rejection after lung transplantation

A study of lung tissue from patients with end-stage bronchiolitis obliterans syndrome (BOS) as a complication of lung transplantation yielded molecular and morphologic insights into the development of chronic rejection.

3 Aug 2021

Mass spectrometry used to develop N-glycosylation profiles for SARS-CoV-2 D614G

A new study has characterized and compared the N-glycosylation of the wild type (S-614D) and variant (S-614G) of SARS-CoV-2 S glycoproteins using MS techniques.

28 Jul 2021

Scientists identify an antiviral metabolite as a potential serum biomarker for SARS-CoV-2 infection

Scientists from the UK have recently identified an antiviral metabolite 3'-Deoxy-3',4'-didehydro-cytidine as a potential serum biomarker to diagnose active severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The study is currently available on the medRxiv* preprint server while awaiting peer review.

27 Jul 2021

Researchers use mass spectrometry to study immunogenic SARS-CoV-2 epitopes

A new study has been published on the bioRxiv* preprint server, which has used MS to identify T cell epitopes of SARS-CoV-2 conserved protein, i.e., the membrane glycol protein (MGP) and the non-structure protein-13 (NSP13).

23 Jul 2021

Spectrometry News and Research

Research reveals a previously unknown role for a key transcription regulator linked to cancer

New low-cost technique helps profile dynamic metabolic features from single isogenic cells

New compounds offer a two-for-one punch to fight estrogen-sensitive breast cancer

Role of glycans on the SARS-CoV-2 spike protein in human receptor interaction

Migraine-inducing peptides may protect against diabetes by influencing insulin production

The influence of COVID-19 on platelet activation and aggregation

Researchers identify a cluster of small molecules that contribute to coffee's mouthfeel

Study pinpoints an enzyme with a significant impact on SARS-CoV-2 replication

Northwestern scientists discover remarkable longevity in a subset of mitochondrial proteins

Studies shed light on the versatility, precision, and sensitivity of quantitative analytical tools

How do glycans affect SARS-CoV-2 spike protein openings?

Study uncovers molecular mechanisms that promote cell-to-cell adhesion and communication

Scientists develop new approach to identify proteins in the living brain

Emerging biosensing technologies could revolutionize the diagnosis of neonatal sepsis

Research shows how SARS-CoV-2 variants are evolving towards increased furin cleavage efficiency

Could a plant metabolite in liverworts be a potent antiviral against SARS-CoV-2 and other RNA viruses?

New molecular and morphologic insights into chronic rejection after lung transplantation

Mass spectrometry used to develop N-glycosylation profiles for SARS-CoV-2 D614G

Scientists identify an antiviral metabolite as a potential serum biomarker for SARS-CoV-2 infection

Researchers use mass spectrometry to study immunogenic SARS-CoV-2 epitopes

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