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New drug combination doubles effectiveness in shrinking enlarged spleens in myelofibrosis patients

Combining the JAK inhibitor ruxolitinib with the BCL-xL inhibitor navitoclax was twice as effective in reducing enlarged spleens – a major indicator of clinical improvement – compared with standard-of-care ruxolitinib monotherapy for adult patients with intermediate or high-risk myelofibrosis, a rare bone marrow cancer, according to results of the Phase III TRANSFORM-1 trial reported by researchers from The University of Texas MD Anderson Cancer Center.

11 Dec 2023

Combination of dasatinib and blinatumomab offers effective treatment for older Ph+ ALL patients

Older patients with Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL) who were not good candidates for the standard treatment of intensive chemotherapy had a median overall survival (OS) of 6.5 years on an alternate regimen of dasatinib and blinatumomab.

11 Dec 2023

Phase I clinical trial of new CAR T cell therapy AT101 shows promising early responses

Early results from a Phase I clinical trial of AT101, a new CAR T cell therapy that uses a distinct binding mechanism to target CD19, show a 100 percent complete response (CR) rate at the higher dose levels studied in the trial, according to researchers from the University of Pennsylvania Perelman School of Medicine and Penn Medicine's Abramson Cancer Center.

11 Dec 2023

New organoid model could revolutionize neuroendocrine tumor research

The Organoid Group (Hubrecht Institute) and the Rare Cancers Genomics Team (IARC/WHO) found a way to grow samples of different types of neuroendocrine tumors (NETs) in the lab.

11 Dec 2023

Study provides a better understanding of how the brain responds to injuries

A new study published in Proceedings of the National Academy of Sciences Nexus provides a better understanding of how the brain responds to injuries.

11 Dec 2023

Natural compound activates macrophages to fight resistant tuberculosis bacteria

Tuberculosis (TB) is a prevalent infectious disease that affects millions of people each year. It was previously the leading cause of death from a single pathogen before the COVID-19 pandemic.

11 Dec 2023

Researchers produce artificial cells with potential for drug delivery and tissue engineering

Artificial cells, made with the use of synthetic materials, have been produced in international research led at the University of Strathclyde.

11 Dec 2023

New atlas characterizes cellular landscape of the early human limb

Human fingers and toes do not grow outward; instead, they form from within a larger foundational bud, as intervening cells recede to reveal the digits beneath. This is among many processes captured for the first time as scientists unveil a spatial cell atlas of the entire developing human limb, resolved in space and time.

11 Dec 2023

‘Naughty but nice’ Christmas foods can help achieve a better balance of cholesterol, expert says

Finally, there’s good news about many of our favorite Christmas foods. A turkey meal with all – well, most – of the trimmings and a traditional dessert can lower your LDL ‘bad’ cholesterol levels and improve your ratio of HDL good cholesterol, reveals a leading testing expert.

11 Dec 2023

Small molecule applications of process Raman spectroscopy

In this interview, Kevin Broadbelt of Thermo Fisher Scientific discusses the small molecule applications of process Raman spectroscopy.

From Thermo Fisher Scientific – Pharmaceutical and Biopharmaceutical Solutions 11 Dec 2023

Machine learning reveals key markers for healthy aging, separate from chronic disease risks

Using machine learning, researchers successfully distinguished factors of healthy aging from chronic disease risks by analyzing health data across various ages, finding key markers like neutrophil counts and alkaline phosphatase levels as early indicators of healthy aging.

10 Dec 2023

Breakthrough in pancreatic cancer treatment: Inhibiting specific enzymes slows tumor progression

Study demonstrates that inhibiting stromal class I histone deacetylases (HDACs) can effectively slow down pancreatic cancer progression, shedding light on a new therapeutic approach targeting the tumor microenvironment.

10 Dec 2023

Key role of ion and water influx in T cell migration uncovered

Research reveals that T cell migration relies on ion and water influx for actin polymerization and movement, with the WNK1 kinase playing a critical role in regulating these processes, offering new insights into adaptive immunity.

10 Dec 2023

Study explores the intricate gut-brain-liver connection and its impact on health

Study reviews the gut-brain-liver axis, revealing the complex interplay between these organs in health and disease and the implications for therapeutic interventions, focusing on how gut microbiota affects liver and brain health.

10 Dec 2023

Study links organic Mediterranean diet to improved male fertility

Researchers in Italy have found that a low-carbohydrate organic Mediterranean diet significantly enhances male fertility by increasing testosterone levels and reducing sperm DNA fragmentation, offering new dietary guidelines for improving male reproductive health.

10 Dec 2023

Cell News and Research

New drug combination doubles effectiveness in shrinking enlarged spleens in myelofibrosis patients

Combination of dasatinib and blinatumomab offers effective treatment for older Ph+ ALL patients

Phase I clinical trial of new CAR T cell therapy AT101 shows promising early responses

New organoid model could revolutionize neuroendocrine tumor research

Study provides a better understanding of how the brain responds to injuries

Natural compound activates macrophages to fight resistant tuberculosis bacteria

Researchers produce artificial cells with potential for drug delivery and tissue engineering

New atlas characterizes cellular landscape of the early human limb

‘Naughty but nice’ Christmas foods can help achieve a better balance of cholesterol, expert says

Small molecule applications of process Raman spectroscopy

Machine learning reveals key markers for healthy aging, separate from chronic disease risks

Breakthrough in pancreatic cancer treatment: Inhibiting specific enzymes slows tumor progression

Key role of ion and water influx in T cell migration uncovered

Study explores the intricate gut-brain-liver connection and its impact on health

Study links organic Mediterranean diet to improved male fertility

Understanding why healthy cells help cancer cells to evade treatment

Using near-infrared spectroscopy to study how infant brains respond to touch

MD Anderson and Rigel partner to expand olutasidenib evaluation in AML and other cancers

Study unlock secrets of Zika virus's multipurpose enzyme and reveals therapeutic vulnerability

Study offers new hope for heart repair and regeneration with reduced mitochondrial activity

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