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New approach promises better drugs for diabetes and osteoporosis

By swapping replacement parts into the backbone of a synthetic hormone, UW-Madison graduate student Ross Cheloha and his mentor, Sam Gellman, along with collaborators at Harvard Medical School, have built a version of a parathyroid hormone that resists degradation in laboratory mice.

18 Jun 2014

Compound developed as cholesterol-fighting molecule can kill cancerous cells

Researchers at the University of Missouri have proven that a compound initially developed as a cholesterol-fighting molecule not only halts the progression of breast cancer, but also can kill the cancerous cells.

18 Jun 2014

Pfizer and Cellectis enter into global strategic collaboration to develop CAR-T immunotherapies

Pfizer Inc. and Cellectis today announced that they have entered into a global strategic collaboration to develop Chimeric Antigen Receptor T-cell (CAR-T) immunotherapies in the field of oncology directed at select targets.

18 Jun 2014

Researchers identify new mechanism by which normal cells turn malignant in mammary epithelial tissues

A team of researchers led by David J. Mooney, Robert P. Pinkas Family Professor of Bioengineering at the Harvard School of Engineering and Applied Sciences, have identified a possible mechanism by which normal cells turn malignant in mammary epithelial tissues, the tissues frequently involved in breast cancer.

17 Jun 2014

Protein test predicts NSCLC survival benefit for chemotherapy over erlotinib

Italian study results confirm that a multivariate serum protein test predicts improved survival after treatment with chemotherapy versus erlotinib for non-small-cell lung cancer, but only among patients who are likely to have a poor outcome with the latter treatment type.

16 Jun 2014

Androgen sensitivity may contribute to hypertrichosis in girls

Prepubertal girls with hypertrichosis are likely to have genetic variants of the androgen receptor known to be particularly sensitive to androgen, say researchers.

16 Jun 2014

Survival differences after docetaxel, erlotinib are EGFR dependent

Results from the DELTA trial indicate no significant differences in progression-free or overall survival after treatment with docetaxel versus erlotinib in non-small-cell lung cancer patients unselected for their epidermal growth factor receptor mutation status.

16 Jun 2014

Risk of breast cancer recurrence associated with carbohydrate intake

Dartmouth researchers have found that reducing carbohydrate intake could reduce the risk of breast cancer recurrence among women whose tumor tissue is positive for the IGF-1 receptor.

13 Jun 2014

Proteins causing daytime sleepiness also play crucial role in bone formation

Orexin proteins, which are blamed for spontaneous daytime sleepiness, also play a crucial role in bone formation, according to findings by UT Southwestern Medical Center researchers.

13 Jun 2014

Tufts researchers gain new insight into protein associated with bipolar disorder

Researchers from Tufts have gained new insight into a protein associated with bipolar disorder. The study, published in the June 3 issue of Science Signaling, reveals that calcium channels in resting neurons activate the breakdown of Sp4, which belongs to a class of proteins called transcription factors that regulate gene expression.

12 Jun 2014

New path may lead to powerful adjunctive novel therapy for PTSD treatment

There are currently only two FDA-approved medications for the treatment of posttraumatic stress disorder (PTSD) in the United States. Both of these medications are serotonin uptake inhibitors. Despite the availability of these medications, many people diagnosed with PTSD remain symptomatic, highlighting the need for new medications for PTSD treatment.

12 Jun 2014

DNA methylation identified as potential anti-TNF response biomarker for RA

DNA methylation has been identified as a potential biomarker of response to etanercept and adalimumab in patients with rheumatoid arthritis (RA) according to preliminary results from one of the largest methylome-wide investigations of treatment response to anti-TNF therapies.

12 Jun 2014

Intake of monounsaturated fatty acids, cholesterol influence disease activity in RA and OA respectively

Two new studies presented today at the European League Against Rheumatism Annual Congress have helped clarify the relationship between the dietary intake of monounsaturated fatty acids and cholesterol with disease activity in rheumatoid arthritis (RA) and osteoarthritis (OA) respectively.

12 Jun 2014

Reducing carbohydrate intake could reduce risk of breast cancer recurrence

Dartmouth researchers have found that reducing carbohydrate intake could reduce the risk of breast cancer recurrence among women whose tumor tissue is positive for the IGF-1 receptor. The study, "Risk of Breast Cancer Recurrence Associated with Carbohydrate Intake and Tissue Expression of IGFI Receptor," will appear in the July issue of Cancer Epidemiology Biomarkers & Prevention.

11 Jun 2014

Combined chemo and radionuclide therapy stops neuroendocrine tumors

Advanced cancer of the neuroendocrine system can lead to dismal prognoses, but a novel therapy is packing a punch by uniting powerful radionuclide treatment and chemotherapy drugs, revealed researchers at the Society of Nuclear Medicine and Molecular Imaging's 2014 Annual Meeting.

10 Jun 2014

Combination of novel molecular imaging techniques can help predict spread of cancer, patient survival

A simple noninvasive blood test matched with state-of-the-art molecular imaging of individual cells could help oncologists understand their patients' chances of survival, say researchers at the Society of Nuclear Medicine and Molecular Imaging's 2014 Annual Meeting.

10 Jun 2014

Antibody-based molecular imaging agent offers hope for novel breast cancer treatments

For years researchers have been developing molecular imaging techniques that visualize hormonally active breast cancer cells-specifically those testing positive for human epidermal growth factor receptor 2 (HER2).

10 Jun 2014

Scientists unravel how herpesviruses fight against our immune system

How the virus does this was unknown until now. The scientists from the HZI research group "Viral Immune Modulation" under the leadership of Prof. Melanie Brinkmann have now been able to show that the virus is actively preventing activation of the innate immune system through Toll-like receptors.

9 Jun 2014

Scientists develop new molecule for monitoring drug concentration

Monitoring the drug concentration in patients is critical for effective treatment, especially in cases of cancer, heart disease, epilepsy and immunosuppression after organ transplants.

9 Jun 2014

Researchers uncover several gene networks with potentially important roles in autism

A large new analysis of DNA from thousands of patients has uncovered several underlying gene networks with potentially important roles in autism.

9 Jun 2014

Receptor News and Research

New approach promises better drugs for diabetes and osteoporosis

Compound developed as cholesterol-fighting molecule can kill cancerous cells

Pfizer and Cellectis enter into global strategic collaboration to develop CAR-T immunotherapies

Researchers identify new mechanism by which normal cells turn malignant in mammary epithelial tissues

Protein test predicts NSCLC survival benefit for chemotherapy over erlotinib

Androgen sensitivity may contribute to hypertrichosis in girls

Survival differences after docetaxel, erlotinib are EGFR dependent

Risk of breast cancer recurrence associated with carbohydrate intake

Proteins causing daytime sleepiness also play crucial role in bone formation

Tufts researchers gain new insight into protein associated with bipolar disorder

New path may lead to powerful adjunctive novel therapy for PTSD treatment

DNA methylation identified as potential anti-TNF response biomarker for RA

Intake of monounsaturated fatty acids, cholesterol influence disease activity in RA and OA respectively

Reducing carbohydrate intake could reduce risk of breast cancer recurrence

Combined chemo and radionuclide therapy stops neuroendocrine tumors

Combination of novel molecular imaging techniques can help predict spread of cancer, patient survival

Antibody-based molecular imaging agent offers hope for novel breast cancer treatments

Scientists unravel how herpesviruses fight against our immune system

Scientists develop new molecule for monitoring drug concentration

Researchers uncover several gene networks with potentially important roles in autism

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