Immune System News and Research

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FDA approves drug for rare, hard-to-treat types of non-Hodgkin lymphoma

The U.S. Food and Drug Administration today approved Poteligeo (mogamulizumab-kpkc) injection for intravenous use for the treatment of adult patients with relapsed or refractory mycosis fungoides or Sézary syndrome after at least one prior systemic therapy.

8 Aug 2018

New CAR T-cell immunotherapy trial targets solid tumors

Seattle Children's has opened a chimeric antigen receptor (CAR) T-cell immunotherapy trial for children and young adults with relapsed or refractory non-central nervous system EGFR-expressing solid tumors. In the phase 1 trial, STRIvE-01, cancer-fighting CAR T cells will target the EGFR protein expressed in many childhood sarcoma, kidney and neuroblastoma tumors.

7 Aug 2018

Access to soil increases mice's resistance to allergic inflammations

When mice live in cages with an added earthen floor, it increases their resistance towards allergic inflammations. Close contact with micro-organisms in the soil triggers anti-inflammatory genes in the mice and stimulates their gut microbiota.

7 Aug 2018

Scientists create new tool to precisely control 3D architecture of linkages in drugs

When it comes to certain molecules, shape makes all the difference. The shape of limonene, for instance, a compound produced by citrus fruits, determines whether it tastes like orange juice or turpentine.

7 Aug 2018

Researchers identify role of infection-fighting cells in inflamed and damaged tissue

Hookworms infect nearly 430 million people in the world, mostly in countries where sanitation is poor, and people often walk barefoot.

7 Aug 2018

Doxorubicin drug causes heart toxicity by disrupting the immune system

Doxorubicin is a chemotherapy drug widely used in ovarian, bladder, lung, thyroid and stomach cancers, but it carries a harmful side effect. The drug causes a dose-dependent heart toxicity that can lead to congestive heart failure.

7 Aug 2018

Unique experimental vaccine against Zika virus proves powerful in mice

A uniquely designed experimental vaccine against Zika virus has proven powerful in mice, new research has found.

6 Aug 2018

Probiotic use could result in disorienting brain fogginess and rapid belly bloating

Probiotic use can result in a significant accumulation of bacteria in the small intestine that can result in disorienting brain fogginess as well as rapid, significant belly bloating, investigators report.

6 Aug 2018

Researchers identify new regulator in breast cancer cells

Triple-negative breast cancer is a particularly aggressive form of breast cancer. Here, important receptors are missing, which often serve as targets for treatments.

6 Aug 2018

New study finds key factors behind differences in immune responses

Age, sex, and specific human genetic variants are the key factors behind differences between immune responses among healthy humans, finds a study of 1,000 individuals carried out by EPFL and the Pasteur Institute.

6 Aug 2018

Clinical trial to use stem cell transplants for treating Crohn's disease

A clinical trial has begun which will use stem cell transplants to grow a new immune system for people with untreatable Crohn's disease - a painful and chronic intestinal disease which affects at least 115,000 people in the UK.

6 Aug 2018

Research uncovers new approach for expanding stem cells from umbilical cord blood

Researchers from the Stowers Institute for Medical Research and collaborators have identified a way to expand blood-forming, adult stem cells from human umbilical cord blood.

3 Aug 2018

Understanding the role of inflammatory cytokines in creating T cell exhaustion in cancer

A better understanding of the role secreted inflammatory cytokines play in the tumor microenvironment that results in the differentiation of effector T cells into exhausted T cells points to possible approaches to improve the antitumor activity of T cells and to intervene in T cell exhaustion.

3 Aug 2018

Study highlights impact of silent viruses on how the host responds to vaccines

UC Davis researchers have shown that low levels of cytomegalovirus (CMV) have a significant impact on microbe and immune cell populations and how the immune system responds to the influenza vaccine. The study was published in the Journal of Virology.

3 Aug 2018

Study sheds new light on link between calorie-burning fat and muscle function

Abundant in human babies and small mammals, brown adipose tissue, or brown fat, was only recently discovered in human adults, and its role remains unclear.

3 Aug 2018

CHOP experts identify new autoimmune disorder along with personalized treatment for young patient

Elijah Patino is a happy, healthy seven-year-old now, but it took a while to get there. For much of his life, he had a mysterious disease that made it painful to eat and painful to play.

2 Aug 2018

Obesity increases viral shedding duration in adults with influenza A

Obesity, which increases influenza disease severity, also extends by about 1.5 days how long influenza A virus is shed from infected adults compared to non-obese adults, according to a multi-year study of two cohorts of Nicaraguan households.

2 Aug 2018

Researchers use DNA editing tool to reveal mechanisms behind autoimmune diseases

A group of researchers at the University of São Paulo in Brazil used a DNA editing tool called CRISPR/Cas9 to manipulate on of the genes associated to the autoaggressive T lymphocytes responsible for inducing autoimmune diseases such as autoimmune polyglandular syndrome type 1 and type 1 diabetes.

2 Aug 2018

Mice study shows mother's dengue immunity protects unborn from ZIKA infection

Dengue and Zika viruses are closely related and carried by mosquitos. In infested subtropical and tropical areas, dengue transmission often precedes Zika virus infection, suggesting that women who previously acquired dengue immunity may be bitten by ZIKV-carrying mosquitoes during pregnancy.

2 Aug 2018

Microscopic imaging helps better understand cancer bone metastasis

Scientists at The University of Texas MD Anderson Cancer Center have engineered a system allowing microscopic monitoring and imaging of cancer that has spread to the bone in mice so they can better understand and develop treatment for bone metastasis in humans.

2 Aug 2018

Immune System News and Research

FDA approves drug for rare, hard-to-treat types of non-Hodgkin lymphoma

New CAR T-cell immunotherapy trial targets solid tumors

Access to soil increases mice's resistance to allergic inflammations

Scientists create new tool to precisely control 3D architecture of linkages in drugs

Researchers identify role of infection-fighting cells in inflamed and damaged tissue

Doxorubicin drug causes heart toxicity by disrupting the immune system

Unique experimental vaccine against Zika virus proves powerful in mice

Probiotic use could result in disorienting brain fogginess and rapid belly bloating

Researchers identify new regulator in breast cancer cells

New study finds key factors behind differences in immune responses

Clinical trial to use stem cell transplants for treating Crohn's disease

Research uncovers new approach for expanding stem cells from umbilical cord blood

Understanding the role of inflammatory cytokines in creating T cell exhaustion in cancer

Study highlights impact of silent viruses on how the host responds to vaccines

Study sheds new light on link between calorie-burning fat and muscle function

CHOP experts identify new autoimmune disorder along with personalized treatment for young patient

Obesity increases viral shedding duration in adults with influenza A

Researchers use DNA editing tool to reveal mechanisms behind autoimmune diseases

Mice study shows mother's dengue immunity protects unborn from ZIKA infection

Microscopic imaging helps better understand cancer bone metastasis

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