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FDA grants approval for first drug to treat inherited breast cancer

The U.S. Food and Drug Administration today expanded the approved use of Lynparza (olaparib tablets) to include the treatment of patients with certain types of breast cancer that have spread (metastasized) and whose tumors have a specific inherited (germline) genetic mutation, making it the first drug in its class (PARP inhibitor) approved to treat breast cancer, and it is the first time any drug has been approved to treat certain patients with metastatic breast cancer who have a "BRCA" gene mutation.

15 Jan 2018

Researchers use immune-mimicking biomaterial scaffolds to fast track T cell therapies

Immunologists and oncologists are harnessing the body's immune system to fight cancers and other diseases with adoptive cell transfer techniques. In a normal immune response, a type of white blood cell known as T cells are instructed by another kind of immune cell called an antigen-presenting cell (APC) to expand their numbers and stay alive.

15 Jan 2018

Researchers develop remote-controlled mechanogenetics system to target and kill cancer cells

A team of researchers has developed an ultrasound-based system that can non-invasively and remotely control genetic processes in live immune T cells so that they recognize and kill cancer cells.

15 Jan 2018

Caltech researchers develop new method to see neural connections in living flies

The human brain is composed of billions of neurons wired together in intricate webs and communicating through electrical pulses and chemical signals.

12 Jan 2018

U.S. FDA approves first drug for patients with germline BRCA-mutated metastatic breast cancer

AstraZeneca and Merck, known as MSD outside the United States and Canada, today announced that the U.S. Food and Drug Administration has approved LYNPARZA (olaparib) for use in patients with deleterious or suspected deleterious germline BRCA-mutated (gBRCAm), human epidermal growth factor receptor 2 (HER2)-negative metastatic breast cancer who have been previously treated with chemotherapy in the neoadjuvant, adjuvant or metastatic setting.

12 Jan 2018

Exposure to estrogen-mimicking compounds may reverse effects of breast cancer treatment

Scientists from The Scripps Research Institute have discovered that two estrogen-mimicking compounds found in many foods appear to potently reverse the effects of palbociclib/letrozole, a popular drug combination for treating breast cancer.

12 Jan 2018

The Virus That Causes Hand, Foot and Mouth Disease May Use Human Protein to Aid Infection

The human protein, prohibitin, may be used by the virus to enter motor neurons and cause the neurological complications of hand, foot and mouth disease.

12 Jan 2018

New TSRI study uncovers workings of first potential treatment for Marburg virus

With a mortality rate of up to 88 percent, Marburg virus can rip through a community in days. In 2005, an outbreak of Marburg virus struck a pediatric ward in the country of Angola. With no treatment available, doctors struggled to help as the virus killed 329 of 374 infected patients.

11 Jan 2018

New HSS study may signal hope for patients suffering from scleroderma

Scleroderma is a terribly debilitating disease with no effective treatments and the mortality rates are still upwards of 20%-50%, the highest of any rheumatic disease.

11 Jan 2018

Researcher provides insight into how stress causes physical symptoms and disease

A Michigan State University researcher is providing new insight into how certain types of stress interact with immune cells and can regulate how these cells respond to allergens, ultimately causing physical symptoms and disease.

10 Jan 2018

UC scientists identify protein that acts as mediator of HER2-driven breast cancer

Researchers at the University of Cincinnati College of Medicine have identified for the first time that the estrogen receptor-binding protein MED1 is a critical mediator of HER2-driven breast cancer, identifying it as a potential therapeutic target.

9 Jan 2018

New drugs and screening techniques reduce breast cancer mortality rates, research shows

In the last few decades, dozens of new breast cancer drugs -- from chemotherapies to targeted compounds -- have become available for clinical use, and mammogram technology has gone from film to digital. But are the changes making a difference in how many women die of breast cancer?

9 Jan 2018

Vanderbilt and Lundbeck collaborate to develop novel approach for treating schizophrenia

Vanderbilt University has signed separate licensing and research collaboration agreements with Lundbeck, a global pharmaceutical company based in Denmark, to develop a novel approach for treating schizophrenia.

9 Jan 2018

New blood stabilization method prolongs lifespan of blood samples for CTC profiling

A new blood stabilization method, developed at the Massachusetts General Hospital Center for Engineering in Medicine, significantly prolongs the lifespan of blood samples for microfluidic sorting and transcriptome profiling of rare circulating tumor cells (CTCs), living cancer cells carried in the bloodstream.

9 Jan 2018

Scientists use artificial intelligence to create new ‘ImmunoMap’

Johns Hopkins scientists have used a form of artificial intelligence to create a map that compares types of cellular receptors, the chemical "antennas" on the surface of immune system T-cells.

8 Jan 2018

Targeted fluorescence successfully identifies pulmonary metastases in osteosarcoma patient

In a proof-of-principle case report, researchers announce that targeted fluorescence successfully identified pulmonary metastases in a patient with osteosarcoma, making it easier for surgeons to locate the tumors for resection.

5 Jan 2018

Researchers pinpoint mechanism for conversion of white fat into brown fat

An international team of researchers led from Karolinska Institutet have, in experiments on mice, pinpointed a mechanism for the conversion of energy-storing white fat into energy-expending brown fat.

5 Jan 2018

Research reveals how Zika virus infection spurs fetal demise

A powerful antiviral protein may act as a checkpoint for keeping or ending a pregnancy.

5 Jan 2018

Adrenomedullin could serve as biomarker, therapeutic target in disorders caused by leaky blood vessels

Disorders caused by a leaky vasculature are more common than most people think. Despite ICU treatment, one third of the 27 million patients globally that suffer from sepsis, and up to 20% of the more than 5 million US patients with congestive heart failure die every year from their condition.

5 Jan 2018

Genetic differences can influence efficiency of medicines

Medicines do not follow the one size fits all principle, because genetic differences can influence their efficiency.

5 Jan 2018

Receptor News and Research

FDA grants approval for first drug to treat inherited breast cancer

Researchers use immune-mimicking biomaterial scaffolds to fast track T cell therapies

Researchers develop remote-controlled mechanogenetics system to target and kill cancer cells

Caltech researchers develop new method to see neural connections in living flies

U.S. FDA approves first drug for patients with germline BRCA-mutated metastatic breast cancer

Exposure to estrogen-mimicking compounds may reverse effects of breast cancer treatment

The Virus That Causes Hand, Foot and Mouth Disease May Use Human Protein to Aid Infection

New TSRI study uncovers workings of first potential treatment for Marburg virus

New HSS study may signal hope for patients suffering from scleroderma

Researcher provides insight into how stress causes physical symptoms and disease

UC scientists identify protein that acts as mediator of HER2-driven breast cancer

New drugs and screening techniques reduce breast cancer mortality rates, research shows

Vanderbilt and Lundbeck collaborate to develop novel approach for treating schizophrenia

New blood stabilization method prolongs lifespan of blood samples for CTC profiling

Scientists use artificial intelligence to create new ‘ImmunoMap’

Targeted fluorescence successfully identifies pulmonary metastases in osteosarcoma patient

Researchers pinpoint mechanism for conversion of white fat into brown fat

Research reveals how Zika virus infection spurs fetal demise

Adrenomedullin could serve as biomarker, therapeutic target in disorders caused by leaky blood vessels

Genetic differences can influence efficiency of medicines

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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