Immune System News and Research

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CU research sheds light on liver disease caused by intravenous nutrition

Research by physician-scientists at the University of Colorado Anschutz Medical Campus offers hope for improved quality of life for people who rely on intravenous nutrition due to intestinal damage.

24 May 2018

Penn investigators discover source of immune molecule involved in nasal polyps, asthma

A new discovery about how the immune system responds to common sinus infections and asthma could explain why patients develop these issues in the first place and ultimately may lead to improved targeted therapies.

23 May 2018

Skin cream containing rapamycin reduces TSC-related facial tumors

Addressing a critical issue for people with a genetic disorder called tuberous sclerosis complex, doctors at The University of Texas Health Science Center at Houston reported that a skin cream containing rapamycin significantly reduced the disfiguring facial tumors affecting more than 90 percent of people with the condition.

23 May 2018

Study provides blueprint of how fruit flies can be used to screen potentially pathogenic human genes

It all began with one young patient; a 7-year old boy who was born without a thymus, an important organ of the immune system, and without functional immune cells. The boy also presented with cardiac and skeletal defects, dysmorphic craniofacial features and some signs of autistic behaviors.

23 May 2018

Advanced genetics study of TB bacteria uncovers virulent 'Beijing lineage' strain among young adults

LSTM's Dr Maxine Caws is co-lead investigator on an advanced genetics study published in Nature Genetics(link is external), which has shown that a virulent strain of tuberculosis (TB) has adapted to transmit among young adults in Ho Chi Minh City, Vietnam.

23 May 2018

Celgene to share new and updated data around novel hematological therapies

Celgene Corporation today announced that data from a broad range of early and late stage studies evaluating Celgene investigational agents and investigational uses of marketed products will be presented at the 23rd European Hematology Association annual meeting in Stockholm, Sweden, from June 14-17, 2018.

22 May 2018

Researchers discover link between tuberculosis and Parkinson's disease

The mechanism our immune cells use to clear bacterial infections like tuberculosis (TB) might also be implicated in Parkinson's disease, according to a new collaborative study led by the Francis Crick Institute, Newcastle University and GSK.

22 May 2018

Pfizer starts Phase 1/2 study of RSV vaccine candidate in healthy adult volunteers

Pfizer Inc. today announced that it has started a Phase 1/2 trial of its respiratory syncytial virus (RSV) vaccine candidate in healthy adult volunteers. RSV is a common respiratory virus that affects the lungs and airways, with significant impact on young children and older adults.

22 May 2018

Novel drug prevents memory impairment in mice exposed to simulated deep space radiation

Planning a trip to Mars? You'll want to remember your anti-radiation pills. NASA and private space companies like SpaceX plan to send humans to the red planet within the next 15 years--but among the major challenges facing future crewed space missions is how to protect astronauts from the dangerous cosmic radiation of deep space.

22 May 2018

Thyroid tumors may be more susceptible to precisely targeted radiation treatment, suggests study

Anaplastic thyroid cancer is almost uniformly fatal, with an average lifespan of about 5 months after diagnosis.

22 May 2018

Researchers create tool to determine patient's response to immunotherapy drugs

Understanding that not all bladder cancers are the same, researchers at the University of North Carolina Lineberger Comprehensive Cancer Center have created a tool that may help them to uncover why only a fraction of patients respond to new immune-based treatments.

21 May 2018

Updated SSC Bundle aims to improve survival for sepsis patients

For patients with sepsis, a serious infection causing widespread inflammation, immediate treatment is essential to improve the chances of survival. An updated "Hour-1 Bundle" of the international, evidence-based guidelines for treatment of sepsis is introduced in the June issue of Critical Care Medicine.

18 May 2018

Study: Psoriasis patients taking Humira show no change in aortic inflammation

An antibody used to treat the skin disease psoriasis and other chronic autoimmune diseases such as rheumatoid arthritis and inflammatory bowel disease has no effect on aortic inflammation – a key marker of future risk of major cardiovascular events – unlike other antibodies that target different aspects of the immune system.

18 May 2018

Study finds body temperature as major barrier to potential dengue, Zika vaccine

A major route toward creating effective vaccines against dengue virus and Zika involves the E protein that covers the surface of each viral particle.

18 May 2018

HIV patients on single-tablet regimen show better outcomes than those taking multiple pills

HIV patients on a single-tablet daily regimen had better treatment retention and viral suppression than patients taking multiple pills, in a study by a Michael E. DeBakey Veterans Affairs Medical Center researcher and his colleagues.

18 May 2018

Study: Macrophages play key role in maintaining stem cell niche of mammary gland

A new study finds that one of the toughest characters in the immune system, the macrophage, has a nurturing side, at least when it comes to guarding the developing breast.

18 May 2018

Study provides insights into how immune cells kill bacteria with acid

The first line of immune defense against invading pathogens like bacteria are macrophages, immune cells that engulf every foreign object that crosses their way. After enclosing it in intracellular membrane vesicles, a process called phagocytosis, macrophages kill their prey with acid.

17 May 2018

Scientists find how immune system helps to clear HBV infection after treatment interruption

Scientists from Karolinska Institutet and Hannover Medical School have published two studies that provide insights into how the immune system responds and helps to clear a hepatitis B infection after treatment interruption.

17 May 2018

Alexo Therapeutics marks next significant milestone by initiating ALX148 combination cohorts

Alexo Therapeutics, a clinical-stage immuno-oncology company developing therapies to block the CD47 checkpoint mechanism, today announced it has initiated ALX148 combination dosing with targeted antibody therapies in its Phase 1 clinical program in patients with advanced solid tumors and lymphoma.

17 May 2018

Lowering blood cholesterol levels could enhance success of T-cell cancer immunotherapy

Cleveland Clinic researchers have demonstrated for the first time that lowering blood cholesterol levels could enhance the success of a specific type of T-cell immunotherapy in fighting cancer.

16 May 2018

Immune System News and Research

CU research sheds light on liver disease caused by intravenous nutrition

Penn investigators discover source of immune molecule involved in nasal polyps, asthma

Skin cream containing rapamycin reduces TSC-related facial tumors

Study provides blueprint of how fruit flies can be used to screen potentially pathogenic human genes

Advanced genetics study of TB bacteria uncovers virulent 'Beijing lineage' strain among young adults

Celgene to share new and updated data around novel hematological therapies

Researchers discover link between tuberculosis and Parkinson's disease

Pfizer starts Phase 1/2 study of RSV vaccine candidate in healthy adult volunteers

Novel drug prevents memory impairment in mice exposed to simulated deep space radiation

Thyroid tumors may be more susceptible to precisely targeted radiation treatment, suggests study

Researchers create tool to determine patient's response to immunotherapy drugs

Updated SSC Bundle aims to improve survival for sepsis patients

Study: Psoriasis patients taking Humira show no change in aortic inflammation

Study finds body temperature as major barrier to potential dengue, Zika vaccine

HIV patients on single-tablet regimen show better outcomes than those taking multiple pills

Study: Macrophages play key role in maintaining stem cell niche of mammary gland

Study provides insights into how immune cells kill bacteria with acid

Scientists find how immune system helps to clear HBV infection after treatment interruption

Alexo Therapeutics marks next significant milestone by initiating ALX148 combination cohorts

Lowering blood cholesterol levels could enhance success of T-cell cancer immunotherapy

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