Infectious Diseases News and Research

RSS

Number of new TB infections fall, but drug resistance, lack of funding could slow progress, WHO reports

"New tuberculosis [TB] infections dropped 2.2 percent worldwide last year, but with nearly nine million new infections, the World Health Organization said TB remains a massive problem that could worsen if countries shortchange funding to fight it," Reuters reports.

19 Oct 2012

TB Alliance and FIND partner to promote development of TB drugs and diagnostics

A new partnership announced today will increase efforts to coordinate the development of complementary novel tools to fight TB, including drug-resistant TB, and identify emerging drug resistance trends around the globe.

19 Oct 2012

Chloride-restrictive intravenous fluids reduce risk for kidney injury

The restrictive use of chloride in intravenous fluids reduces the risk for acute kidney injury and renal replacement therapy, research shows.

18 Oct 2012

Ciclosporin no more effective than infliximab in severe UC

Ciclosporin and infliximab have similar efficacy for the treatment of patients with refractory severe ulcerative colitis, show the findings of a multinational trial.

18 Oct 2012

Novel drug increases survival in animal models exposed to high-dose radiation

A novel drug that mimics a naturally occurring molecule found in coffee and blueberries has been developed to treat radiation exposure. Charles R. Yates, Pharm.D., Ph.D., and colleagues Duane Miller, Ph.D., and Waleed Gaber, Ph.D., from the University of Tennessee Health Science Center and Baylor College of Medicine, show that application of this drug, starting 24 hours after radiation exposure, increases survival in animal models by three-fold compared to placebo.

17 Oct 2012

BioLineRx completes pre-clinical development of BL-8020 for HCV

BioLineRx, a biopharmaceutical development company, announced today that it has successfully completed the pre-clinical development of BL-8020, an orally available, interferon-free treatment for the Hepatitis C virus (HCV), and plans to commence a Phase I/II safety and efficacy study for BL-8020 in Europe during the first quarter of 2013.

17 Oct 2012

Antibiotic injections are associated with lower risk of infection in cataract surgery

Intracameral antibiotic injections were associated with a 22-fold reduction in the risk of postoperative infection following cataract surgery when compared with the standard post-operative treatment of antibiotic eyedrops, according to a Kaiser Permanente study.

16 Oct 2012

LRRK2 inhibitors may provide neuroprotection for patients with Parkinson's

For decades, patients with Parkinson's disease (PD) have had the same experience. Their hands start to shake uncontrollably, their limbs become rigid and they lose their balance. Years before those movement problems set in, many begin struggling with fainting, incontinence, sexual dysfunction, anxiety and depression. Many patients are still treated with a 42-year-old drug called L-DOPA, which temporarily staves off symptoms but can itself cause heart arrhythmias, stomach bleeding and hallucinations.

16 Oct 2012

Gravity changes affect immune system development

New research findings recently published in The FASEB Journal, show that immune system development is affected by gravity changes, as reported by researchers from the University of Lorraine and University of Luxembourg. Astronauts are exposed to stresses, during launch and landing, which disrupts their body's natural defenses against infection. Changes to the immune system need to be investigated before astronauts undergo longer space missions.

16 Oct 2012

NIAID-funded study to evaluate PPSV23 and PCV13 in Phase Iib pneumococcal trial

Researchers plan to see if a higher dose of a pneumococcal vaccine will create a stronger immune response in older adults who received an earlier generation vaccine against pneumonia and other pneumococcal diseases.

16 Oct 2012

Experts discuss recent U.S. meningitis outbreak at ANESTHESIOLOGY 2012 meeting

Four experts in anesthesiology, infectious disease and pain medicine discussed the recent U.S. meningitis outbreak in the Late-Breaking Education Panel, "The Fungal Meningitis Crisis," on Sunday, Oct. 14.

16 Oct 2012

Screening practices for multidrug-resistant organisms in ICUs vary widely between hospitals

Screening practices for multidrug-resistant organisms (MDROs) in intensive care units (ICUs) vary widely from hospital to hospital, according to a new study by researchers at Columbia University School of Nursing and published in the October 2012 issue of the American Journal of Infection Control.

16 Oct 2012

Saint Louis University to participate in PPV23 vaccine trial for pneumonia

Saint Louis University is participating in a multi-site, National Institutes of Health-sponsored clinical trial in older adults of a new vaccine designed to protect against one of the most common types of pneumonia and related diseases such as bloodstream infections and meningitis.

16 Oct 2012

Environmental factors affect pneumonia hospitalization in HIV

Hospital admissions for Pneumocystis pneumonia in HIV-infected individuals are significantly more common in the summer months, US research shows.

15 Oct 2012

Therapeutic HPV16 and HPV18 vaccine ‘may eliminate infection’

A candidate vaccine against human papillomavirus serotypes 16 and 18 appears to induce robust immune responses to antigens, potentially leading to the elimination of virus-infected cells and regression of dysplasia, say US investigators.

15 Oct 2012

Merck, AiCuris enter licensing agreement for novel HCMV candidates

Merck, known as MSD outside the United States and Canada, and AiCuris today announced that they have entered into an exclusive worldwide licensing agreement for AiCuris' novel portfolio of investigational medicines targeting Human Cytomegalovirus (HCMV), including letermovir (AIC246), an oral, late-stage antiviral candidate being investigated for the treatment and prevention of HCMV infection in transplant recipients.

15 Oct 2012

Researchers develop two ultra-rapid tests for diagnosis of antibiotic resistance

With their excellent sensitivity and specificity, the use of these extremely efficient tests on a world-wide scale would allow us to adapt antibiotic treatments to the individual's needs and to be more successful in controlling antibiotic resistance, particularly in hospitals.

15 Oct 2012

Database of drug-induced liver injury now available from NIH

A free source of evidence-based information for health care professionals and for researchers studying liver injury associated with prescription and over-the-counter drugs, herbals, and dietary supplements is now available from the National Institutes of Health. Researchers and health care professionals can use the LiverTox database to identify basic and clinical research questions to be answered and to chart optimal ways to diagnose and control drug-induced liver injury.

15 Oct 2012

Researchers identify keys and doors of Anaplasmataceae tick-borne bacterium

Virginia Commonwealth University School of Medicine researchers have identified the "keys" and "doors" of a bacterium responsible for a series of tick-transmitted diseases. These findings may point researchers toward the development of a single vaccine that protects against members of an entire family of bacteria that cause disease in humans, domestic animals and livestock.

15 Oct 2012

Researchers identify molecular emergency brake in charge of regulating self-digestion

Almost everything that happens inside a cell, including autophagy, is tightly regulated on a biochemical level. Like that, the cell makes sure that processes only take place when they are needed and that they are shut off when the need has expired. "Inside the cell, there exists a network of molecules. Between them, information is constantly being exchanged," says Schmitz, head of the research group "Systems-oriented Immunology and Inflammation Research" at HZI, who also holds a chair at the Otto von Guericke University in Magdeburg.

15 Oct 2012