DNA Sequencing News and Research

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Scientists have made breakthrough in understanding cancer-promoting action of herbal products

A team of scientists from the National Cancer Centre Singapore, Duke-NUS Graduate Medical School Singapore, and Taiwan's Chang Gung Memorial Hospital, LinKou, have made a breakthrough in understanding the cancer-promoting action of Aristolochic Acid (AA), a natural product of Aristolochia plants traditionally used in some Asian herbal remedies for weight loss and slimming.

14 Aug 2013

Coalition with Innovative Life Sciences delivers best medicine in oncology for cancer patients

GenoSpace, PathGroup and the IP & Science business of Thomson Reuters today announced an innovative initiative to develop and deliver a best-in-class personalized medicine service in oncology, the result of which will enable physicians to make more precise therapeutic recommendations for cancer patients.

13 Aug 2013

Study of childhood epilepsies links two new genes to severe forms of disease

A genetic study of childhood epilepsies has linked two new genes to severe forms of disease and provides a novel strategy for identifying therapy targets. This study used a cutting-edge genetic technique, called exome sequencing, to search for new mutations that are not inherited.

12 Aug 2013

Four genetic variants in non-small cell lung cancer patients help predict survival, treatment response

Researchers at the Moffitt Cancer Center have identified four inherited genetic variants in non-small cell lung cancer patients that can help predict survival and treatment response. Their findings could help lead to more personalized treatment options and improved outcomes for patients.

9 Aug 2013

Children born by Caesarean section more vulnerable to allergies

Children who came into the world by Caesarean section are more often affected by allergies than those born in the natural way. The reason for this may be that they have a less diverse gut microbiota, according to a study by universities in Sweden and Scotland.

9 Aug 2013

Columbia researchers identify 18 new genes that drive glioblastoma multiforme

A team of researchers at the Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center has identified 18 new genes responsible for driving glioblastoma multiforme, the most common-and most aggressive-form of brain cancer in adults. The study was published August 5, 2013, in Nature Genetics.

6 Aug 2013

Specific mutations in FLT3 receptor can contribute to acute myeloid leukemia

Specific mutations (N676K) in the FLT3 receptor can contribute to the development of acute myeloid leukemia. The FLT3 receptor regulates cell growth, while activating gene mutations promote the uncontrolled proliferation of white blood cells. These findings were reported in the specialist journal Blood by a group of scientists from the Helmholtz Zentrum München and the Hospital of the Ludwig Maximilians University in Munich as part of a clinical research collaboration with the German Cancer Consortium.

3 Aug 2013

Study offers new hope for treatment of diffuse large B-cell lymphoma

Researchers have discovered how an experimental drug is capable of completely eradicating human lymphoma in mice after just five doses. The study, led by researchers at Weill Cornell Medical College, sets the stage for testing the drug in clinical trials of diffuse large B-cell lymphoma, the most common subtype of non-Hodgkin lymphoma, itself the seventh most frequently diagnosed cancer in the U.S.

2 Aug 2013

Professor receives Celebration of African Australians Inc Award for exceptional research works

Professor Vanessa Hayes received a Celebration of African Australians Inc Award at Parliament House on Saturday.

30 Jul 2013

Statins: A class of cholesterol-lowering drugs may help treat Rett Syndrome

Statins, a class of cholesterol-lowering drugs found in millions of medicine cabinets, may help treat Rett Syndrome, according to a study published today in Nature Genetics. The Rett Syndrome Research Trust (RSRT) funded this work with generous support from the Rett Syndrome Research Trust UK and Rett Syndrome Research & Treatment Foundation.

30 Jul 2013

New clinic focuses on men with fast-growing prostate cancer

While every year about 30,000 men die of prostate cancer in the United States, the most common cause of death in men with prostate cancer is heart disease. That's because not all prostate cancers are the same. Some are slow-growing while others are very aggressive.

25 Jul 2013

Inovio plans to advance synthetic hTERT cancer vaccine into clinical trials in 2014

Inovio Pharmaceuticals, Inc. announced today that in a preclinical study with two animal models, Inovio's hTERT (human telomerase reverse transcriptase) DNA cancer vaccine administered with Inovio's CELLECTRA adaptive electroporation delivery technology generated robust and broad immune responses, broke the immune system's tolerance to its self-antigens, induced T-cells with a tumor-killing function, and increased the rate of survival.

24 Jul 2013

Study results suggest reexamination of biological, medical importance of X chromosome

Painstaking new analysis of the genetic sequence of the X chromosome—long perceived as the "female" counterpart to the male-associated Y chromosome—reveals that large portions of the X have evolved to play a specialized role in sperm production.

24 Jul 2013

Four research teams receive NIH grants to explore use of genome sequencing in medical care

The National Institutes of Health has awarded four grants for up to four years to multidisciplinary research teams to explore the use of genome sequencing in medical care. The awards total approximately $6.7 million in the first year and, if funding remains available, approximately $27 million in total.

24 Jul 2013

p53 and cancer research: an interview with Professor Sir David Lane, Scientific Director of the Ludwig Institute for Cancer Research

P53 is a tumor suppressor gene. The gene encodes for a protein that monitors the state of the cell. If something goes wrong, it stops the cell from dividing or causes the cell to commit suicide. I call it the “guardian of the genome” as it is the molecule that seems to keep cells normal. It is one of our big defenses against cancer.

22 Jul 2013

Scientists discover molecular switch that determines death or survival of cell

The study is the result of a collaboration of scientists at Karolinska Institutet in Sweden, University of Michigan, and University of California San Diego, USA, who were interested in finding out whether autophagy can be affected by events in the cell nucleus. Surprisingly, they discovered that a signal chain in the nucleus serves as a kind of molecular switch that determines whether the cell dies or survives.

19 Jul 2013

CHOP-led research increases numbers of patients who could be treated with gene therapy

Gene therapy researchers have produced a bioengineered decoy that fools the immune system and prevents it from mistakenly defeating the benefits delivered by a corrective gene.

18 Jul 2013

Recent advances put melanoma at the forefront of cancer research

A decade ago there was little doctors could do to help a patient with advanced-stage melanoma. Now it seems each week yields important new discoveries about the deadly skin cancer.

17 Jul 2013

High folate intake during pregnancy may have undiscovered later-life effect in progeny

During pregnancy, women are normally advised to take high amounts of multivitamin supplements. In particular, folate is recommended to reduce the risk of neural tube defects in newborns. The problem is that, although vitamins are critical in fetal development, high vitamin doses during pregnancy may cause undesired effects on the offspring later in life.

15 Jul 2013

General DNA sequencing can reveal previously undetectable viruses

There are 170 established HPV types. Cancerous human papillomavirus (HPV) viruses are the main cause of cervical cancer, and are found in close to 100% of cervical tumors.

12 Jul 2013

DNA Sequencing News and Research

Scientists have made breakthrough in understanding cancer-promoting action of herbal products

Coalition with Innovative Life Sciences delivers best medicine in oncology for cancer patients

Study of childhood epilepsies links two new genes to severe forms of disease

Four genetic variants in non-small cell lung cancer patients help predict survival, treatment response

Children born by Caesarean section more vulnerable to allergies

Columbia researchers identify 18 new genes that drive glioblastoma multiforme

Specific mutations in FLT3 receptor can contribute to acute myeloid leukemia

Study offers new hope for treatment of diffuse large B-cell lymphoma

Professor receives Celebration of African Australians Inc Award for exceptional research works

Statins: A class of cholesterol-lowering drugs may help treat Rett Syndrome

New clinic focuses on men with fast-growing prostate cancer

Inovio plans to advance synthetic hTERT cancer vaccine into clinical trials in 2014

Study results suggest reexamination of biological, medical importance of X chromosome

Four research teams receive NIH grants to explore use of genome sequencing in medical care

p53 and cancer research: an interview with Professor Sir David Lane, Scientific Director of the Ludwig Institute for Cancer Research

Scientists discover molecular switch that determines death or survival of cell

CHOP-led research increases numbers of patients who could be treated with gene therapy

Recent advances put melanoma at the forefront of cancer research

High folate intake during pregnancy may have undiscovered later-life effect in progeny

General DNA sequencing can reveal previously undetectable viruses

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