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Study isolates mania-specific genetic architecture in bipolar disorder

Researchers at King's College London and the University of Florence have, for the first time, identified the specific genetic blueprint of mania, the defining feature of bipolar disorder.

27 Jan 2026

First topical CRISPR gene therapy corrects disease-causing mutations in human skin

Gene-editing tools like CRISPR have unlocked new treatments for previously uncurable diseases. Now, researchers at the University of British Columbia are extending those possibilities to the skin for the first time.

27 Jan 2026

Tracking antibiotic resistance across environmental systems using advanced metagenomic tools

Antibiotic resistance is often framed as a hospital problem, but a growing body of evidence shows that the environment plays an equally critical role in the global spread of drug resistant bacteria.

27 Jan 2026

How modern lifestyles reprogram the gut microbiome and shape disease risk

Modern lifestyle factors such as circadian disruption, sleep deprivation, stress, and exercise reshape the gut bacteriome and its metabolic outputs. These microbiome changes are linked to immune, metabolic, and cancer-related pathways, largely through evidence from animal models and observational human studies.

27 Jan 2026

Brain organoids reveal glioblastoma's secrets and therapy resistance

UCLA scientists have developed advanced miniature 3D tumor organoid models that make it possible to study glioblastoma tumors in a setting that closely mirrors the human brain, shedding light on how the aggressive cancer interacts with surrounding brain cells and the immune system to become more invasive and resistant to therapy.

27 Jan 2026

Study identifies genes, smoking, and obesity as pneumonia risk factors

Researchers at the University of Oulu have identified genes that increase susceptibility to pneumonia. Alongside inherited risk factors, smoking and higher body mass were also found to raise the risk of developing the disease.

27 Jan 2026

KAIST proposes novel strategy for multifactorial Alzheimer's treatment

Conventional treatments of Alzheimer's disease, one of the most common forms of dementia, have been largely focused on targeting individual pathological features.

27 Jan 2026

Multi-fluid microRNA signals as markers of endometriosis

Researchers uncover distinct microRNA profiles in bodily fluids, offering insights into noninvasive diagnostic markers for endometriosis and its complexities.

27 Jan 2026

New atlas of brain lysosomes sheds light on neurodegenerative disorders

Functioning brain cells need a functioning system for picking up the trash and sorting the recycling. But when the cellular sanitation machines responsible for those tasks, called lysosomes, break down or get overwhelmed, it can increase the risk of Alzheimer's, Parkinson's, and other neurological disorders.

27 Jan 2026

WVU researchers explore how to restore vision in people with inherited blindness

A research team at the WVU is studying how to restore vision in people who develop a form of inherited blindness.

26 Jan 2026

Gene therapy targeting connexin 43 shows promise across inherited heart diseases

University of California San Diego-led team has discovered that restoring a key cardiac protein called connexin‑43 in a mouse model can dramatically improve heart function and extend survival in several inherited forms of arrhythmogenic cardiomyopathy (ACM)

26 Jan 2026

Physical behavior reveals aggressive cancer cells in a simple new approach

New study shows that aggressive cancer cells can be identified in a simple, new way; by how they physically behave, not just by their genes.

26 Jan 2026

Genetic study reveals immune-related roots of allergic conjunctivitis

Allergic conjunctivitis is one of the most common eye conditions. A new large-scale genetic study shows that susceptibility to the disease is strongly linked to genes that regulate inflammation and immune defense.

26 Jan 2026

Secondary-treated wastewater still transfers antibiotic resistance to fresh produce

A study reveals tertiary-treated wastewater significantly reduces antimicrobial resistance risks in lettuce irrigation compared to secondary-treated water.

26 Jan 2026

Orphan noncoding RNAs define cancer identity and enable blood-based monitoring

We knew we had something interesting with T3p, a single small RNA found in breast cancer but absent from normal tissue.

24 Jan 2026

Unraveling liver injury mechanisms in familial hypobetalipoproteinemia

Familial Hypobetalipoproteinemia (FHBL), caused by variants in the apolipoprotein B (APOB) gene, is a rare autosomal co-dominant monogenic disorder characterized by lifelong low plasma levels of total cholesterol, low-density lipoprotein cholesterol (LDL-C), and APOB.

24 Jan 2026

Shared genetic architecture links schizophrenia with hemispheric white matter microstructure

Schizophrenia is a highly heterogeneous psychiatric disorder affecting ~1% of the global population, typically emerging in adolescence or early adulthood and characterized by hallucinations, delusions, disorganized thinking, and cognitive impairments; while its etiology remains elusive, genetic factors are widely recognized as fundamental, and GWAS have identified over 200 genome-wide significant loci.

24 Jan 2026

MYC cancer gene suppresses immune alarm signals to protect pancreatic tumors

The cancer gene MYC camouflages tumors by suppressing alarm signals that normally activate the immune system.

23 Jan 2026

Genetic study links vitamin B1 metabolism to gut motility and IBS risk

Research links thiamine metabolism to gut motility, identifying genetic markers that could lead to new therapies for IBS and related digestive disorders.

23 Jan 2026

Ageing slows brain protein clearance and shifts synaptic waste to microglia

Ageing slows neuronal protein degradation in mice, leading to widespread accumulation and aggregation of long-lived proteins, particularly at synapses. As neuronal clearance declines, microglia selectively accumulate synaptic proteins, suggesting a compensatory but potentially strained proteostasis pathway in the ageing brain.

22 Jan 2026