Metabolic Disorders News and Research

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Three research groups awarded NIH grants to develop framework for evaluating genetic variants

Three grants totaling more than $25 million over four years will help three research groups to develop authoritative information on the millions of genomic variants relevant to human disease and the hundreds that are expected to be useful for clinical practice. The awards are from the National Institutes of Health.

26 Sep 2013

Understanding genetic, physiological basis for metabolic diseases related to circadian function

A new study by a team of University of Notre Dame researchers, which appears in the Sept. 2 edition of the journal PLoS ONE, is a significant step in understanding the molecular genetic and physiological basis for a spectrum of metabolic diseases related to circadian function.

24 Sep 2013

Gender warns of bipolar I disorder risks

Researchers have confirmed several features that differ between men and women with bipolar disorder, which may impact on the course and treatment of the condition.

11 Sep 2013

Weill Cornell Medical College gets $100M gift to launch Driving Discoveries, Changing Lives campaign

Weill Cornell Medical College announced today that it has received a $100 million gift from longtime benefactors Joan and Sanford I. Weill and the Weill Family Foundation to launch the Medical College's $300 million Driving Discoveries, Changing Lives campaign dedicated to using the most advanced scientific approaches to rapidly translate research breakthroughs into innovative treatments and therapies for patients.

10 Sep 2013

Parasites could be potential key to treating autoimmune diseases

There is a new weapon in the fight against autoimmune diseases such as Type 1 diabetes, rheumatoid arthritis, Crohn's disease and lupus, the common trait of which is an immune system that attacks its own organs and tissues.

10 Sep 2013

More than 3,000 chemicals or "metabolites" can be detected in urine, say researchers

Researchers at the University of Alberta announced today that they have determined the chemical composition of human urine. The study, which took more than seven years and involved a team of nearly 20 researchers, has revealed that more than 3,000 chemicals or "metabolites" can be detected in urine.

6 Sep 2013

Being overweight but metabolically healthy is not linked with increased risk of heart attack

Metabolically healthy women have the same cardiovascular disease risk regardless of their BMI, according to research presented at the ESC Congress today by Dr S-ren Sk-tt Andersen and Dr Michelle Schmiegelow from Denmark.

2 Sep 2013

Increased caffeine intake may reduce fatty liver in people with NAFLD

Surprise! Your morning cup of tea or coffee may be doing more than just perking you up before work. An international team of researchers led by Duke-NUS Graduate Medical School (Duke-NUS) and the Duke University School of Medicine suggest that increased caffeine intake may reduce fatty liver in people with non-alcoholic fatty liver disease (NAFLD).

17 Aug 2013

Researchers now have more complete picture of mTORC1 pathway that can lead to cancer, diabetes

Deciphering the body's complex molecular pathways that lead to disease when they malfunction is highly challenging. Researchers at Sanford-Burnham Medical Research Institute now have a more complete picture of one particular pathway that can lead to cancer and diabetes. In the study published by Molecular Cell, the scientists uncovered how a protein called p62 has a cascade affect in regulating cell growth in response to the presence of nutrients such as amino acids and glucose. Disrupting this chain may offer a new approach to treating disease.

2 Aug 2013

HHS Inspector General raises concerns about Medicare policy on observation care

The report also finds that policies on admitting patients or keeping them under observation -- a distinction that can have dramatic financial impact on the patients -- varies substantially among hospitals.

31 Jul 2013

TSRI scientists study 3-D structure of glucagon receptor for treatment of diabetes

The study is reported on July 17, 2013, in an advance online edition of the journal Nature, alongside a British laboratory's structural study of another member of the same class of receptors-known as "class B" G protein-coupled receptors (GPCRs).

18 Jul 2013

Alize Pharma initiates AZP-531 Phase I clinical trial for treatment of type 2 diabetes

Alize Pharma, a company specialized in the development of drugs for the treatment of metabolic diseases and rare diseases, announces today the launch of the first Phase I clinical trial for AZP-531, its unacylated ghrelin analog, in type 2 diabetes.

16 Jul 2013

Obese fathers may pass their obesity to children and grandchildren

New research from the University of Adelaide shows that the sperm of obese fathers could increase the risk of both their children and their grandchildren to inherit obesity.

16 Jul 2013

Obese fathers pass on diseases to kids

If you are obese and hope to be a father, here's another reason to lose weight: your children and grandchildren may inherit your waistline or metabolic disorders. That's because scientists have discovered in mice that obese fathers, even those who did not show any signs of diabetes, passed this negative trait on most frequently to their daughters. Sons don't entirely dodge this genetic bullet either-both sons and daughters of obese fathers have increased risks of developing metabolic diseases, such as diabetes.

12 Jul 2013

Research shows food contaminants are responsible for metabolic changes in obese mice

In order to get a better understanding of these effects, researchers from the Inserm cardiovascular, metabolism, diabetology and nutrition unit introduced a "cocktail" of contaminants mixed with low doses of dioxin, PCB, bisphenol A and phtalates into the feeding of mice that had already been rendered obese by a high-fat diet.

28 Jun 2013

Researchers find RNA molecule that interferes with lipoprotein production, reduces hyperlipidemia

Hyperlipidemia, a condition with high levels of fats circulating in the bloodstream, is a known risk factor for various cardiovascular and metabolic disorders. While the Western diet often contributes to high levels of lipids such as cholesterol and triglycerides, over-production of the body's own lipoproteins can lead to hyperlipidemia, independent of food intake.

25 Jun 2013

MIT study shows that SIRT1 gene plays key role in controlling circadian rhythms

Human sleeping and waking patterns are largely governed by an internal circadian clock that corresponds closely with the 24-hour cycle of light and darkness. This circadian clock also controls other body functions, such as metabolism and temperature regulation.

21 Jun 2013

Special type of IVF may increase risk for insulin resistance among children

A special type of in vitro fertilization, or IVF, may increase the risk for insulin resistance among children conceived in this way, according to a new study from Greece. The results will be presented Monday at The Endocrine Society's 95th Annual Meeting in San Francisco.

18 Jun 2013

People suffering from PTSD have risk of developing type 2 diabetes

The presence of posttraumatic stress disorder is significantly associated with the development of type 2 diabetes. This is the finding of scientists from the Helmholtz Zentrum München and the University Hospital Gieβen and Marburg who worked with data from the population-based KORA cohort study.

16 May 2013

Aileron Therapeutics concludes first-in-human study of ALRN-5281 Stapled Peptide drug

Aileron Therapeutics, Inc. today announced the completion of the first-in-human study of its lead Stapled Peptide drug, ALRN-5281, a proprietary, long-acting growth-hormone-releasing hormone (GHRH) agonist for treating orphan endocrine disorders, including adult growth hormone (GH) deficiency and human immunodeficiency virus (HIV) lipodystrophy, as well as broader patient populations involving a wide variety of metabolic/endocrine diseases.

7 May 2013