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Targeting a key protein outside of the brain could help manage Parkinson's-related heart issues

Parkinson's doesn't just affect movement and the brain - it may also impact the heart, according to new research from the University of Surrey. Scientists from Surrey's School of Veterinary Medicine suggest that targeting a key protein outside of the brain could help manage Parkinson's-related heart issues.

3 Apr 2025

NUZ-001 shows positive results in human 3D brain model

Neurizon Therapeutics Limited (“Neurizon”), a clinical-stage biotech company dedicated to advancing treatments for neurodegenerative diseases, is pleased to advise that results from an independent study undertaken in collaboration with Tessara Therapeutics (“Tessara”) will be presented by the group’s Principal Scientist and Alzheimer’s Disease expert, Dr Mark Greenough at the AD/PD 2025 Advances in Sciences & Therapy conference on April 2nd to 3rd.

3 Apr 2025

How your skin’s microbes shape immunity, inflammation, and chronic skin disease

Skin microbes do more than coexist—they shape immune responses, repair tissue, and influence gene expression across your lifespan. This review explains how disruptions in this microbiome-immune dialogue can lead to eczema, psoriasis, or acne.

2 Apr 2025

New drug shows neuroprotective and anti-inflammatory effects in murine models of Alzheimer's

Alzheimer's disease, the most common cause of dementia, is currently incurable. The current drugs available have very limited efficacy and only in mild stages of the disease.

2 Apr 2025

New drug restores vision by regenerating retinal nerves

Vision is one of the most crucial human senses, yet over 300 million people worldwide are at risk of vision loss due to various retinal diseases.

1 Apr 2025

Weight training shields the brain from dementia in older adults

The benefits of weight training are many: it promotes gains in strength and muscle mass, reduces body fat, and contributes to well-being and mental health.

1 Apr 2025

Queen Mary scientists invent a new way to repair osteochondral defects

Scientists at Queen Mary University of London have invented a new way to repair osteochondral defects – a common form of joint damage often caused by sports injuries or trauma – and to prevent progression to osteoarthritis.

1 Apr 2025

ALL ALS Consortium creates a central information hub to accelerate ALS research

The Access for All in ALS (ALL ALS) Consortium announced the launch of its official website, creating a central hub for information about its initiatives and clinical research studies. ALL-ALS.org is designed to inform and engage researchers, clinicians, and current and prospective study participants.

31 Mar 2025

Hedonic eating fades with obesity—but neurotensin helps bring it back

Chronic high-fat diets blunt the brain’s pleasure response to rich foods by impairing NAcLat→VTA signaling in mice. Neurotensin dysfunction underlies this effect, but restoring its signaling revives hedonic feeding and reduces obesity symptoms.

30 Mar 2025

Artificial neurons learn independently in self-organized networks

Novel artificial neurons learn independently and are more strongly modeled on their biological counterparts.

28 Mar 2025

New insights into how glutamate opens brain cell signaling channels

In an effort to understand how brain cells exchange chemical messages, scientists say they have successfully used a highly specialized microscope to capture more precise details of how one of the most common signaling molecules, glutamate, opens a channel and allows a flood of charged particles to enter.

28 Mar 2025

New insights into how the immune system handles latent parasite infections

Most humans have long-lived infections in various tissues-including in the nervous system-that typically do not result in disease.

28 Mar 2025

Study finds 24-hour fasting cycles enhance libido in male mice

Long-term fasting in 24-hour cycles increases the sex drive of male mice by lowering the concentration of the neurotransmitter serotonin in the brain.

28 Mar 2025

Scientists develop lab model to study TDP-43 accumulation in neurodegeneration

Accumulation of a protein called TDP-43 is a key feature of ALS and frontotemporal dementia. In a newly published study, researchers report 'seeding' this accumulation through fragments of the culprit protein created in the lab.

28 Mar 2025

How HIIT and intermittent fasting alter metabolism in postmenopausal women

How the combination of HIIT with intermittent fasting or a low-calorie diet improves metabolic health among postmenopausal women.

28 Mar 2025

Auburn researchers discover fundamental principle of how brain cells stay connected

Scientists at Auburn University have uncovered a fundamental principle of how brain cells stay connected, and their discovery could change how we understand Alzheimer's disease.

27 Mar 2025

Dopamine neurons play a central role in sustaining hedonic eating

A previously overlooked dopamine-producing brain circuit drives hedonic eating, or eating for pleasure, according to a new study in mice.

27 Mar 2025

Unveiling leptin signaling in the DMH for metabolic effects

Scientists at Pennington Biomedical Research Center have gained greater clarity in the brain regions and neurons that control metabolism, body temperature and energy use.

27 Mar 2025

Discovery provides crucial molecular targets for future obesity treatments

The pleasure we get from eating junk food - the dopamine rush from crunching down on salty, greasy French fries and a luscious burger - is often blamed as the cause of overeating and rising obesity rates in our society.

26 Mar 2025

Study highlights the flexible nature of numerical quantity processing in the brain

The National Institute of Information and Communications Technology (NICT, President: TOKUDA Hideyuki, Ph.D.) has revealed, through fMRI-based brain activity analysis, that multiple regions in the human cerebral cortex flexibly represent numerical quantity.

26 Mar 2025