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Scientists reveal timing mechanism in formation of vertebrae

As they develop, vertebrate embryos form vertebrae in a sequential, time-controlled way. Scientists have determined previously that this process of body segmentation is controlled by a kind of "clock," regulated by the oscillating activity of certain genes within embryonic cells. But questions remain about how precisely this timing system works.

14 Nov 2012

Patients with gastric cancer have impaired TGFβig-h3 protein

Scientists at the University of Liverpool have found that the production of a protein that prevents the growth and spread of cancerous cells is impaired in patients with gastric cancer.

14 Nov 2012

Study indicates that impact of early-life abuse extend well into older age

The psychological scars of childhood abuse can last well into adulthood. New research from Concordia University shows the harm can have longterm negative physical effects, as well as emotional ones.

14 Nov 2012

Atpif1 gene regulates heme synthesis in red blood cell formation

Scientists at the University of Georgia, Harvard Medical School and the University of Utah have discovered a new gene that regulates heme synthesis in red blood cell formation. Heme is the deep-red, iron-containing component of hemoglobin, the protein in red blood cells responsible for transporting oxygen in the blood.

14 Nov 2012

Neuroticism can be good for health under certain circumstances

Under certain circumstances neuroticism can be good for your health, according to a University of Rochester Medical Center study showing that some self-described neurotics also tended to have the lowest levels of Interleukin 6 (IL-6), a biomarker for inflammation and chronic disease.

14 Nov 2012

Scientists discover how external signals regulate vascular remodelling at cell level

Blood vessels are extremely dynamic: depending on the external conditions, they can adapt their permeability for nutrients, their contractility, and even their shape. Unlike cardiac muscle cells, for example, the smooth muscle cells in blood vessels demonstrate a high degree of plasticity, so they can specialise or multiply as required, even repairing damage to the vessel wall.

13 Nov 2012

Cancer metastasis research facilitated by nanoparticle characterization technology from NanoSight

NanoSight, leading manufacturers of unique nanoparticle characterization technology, reports on the breakthrough cancer metastasis research of Dr. Hector Peinado Selgas and Dr. David Lyden's research team from Weill Cornell Medical College.

13 Nov 2012

Monoclonal antibody boosts cholesterol reduction

Adding a monoclonal antibody that blocks the breakdown of lipid receptors to atorvastatin therapy further reduces low-density lipoprotein cholesterol levels in patients with primary hypercholesterolemia, show study findings.

9 Nov 2012

Patients with focal segmental glomerulosclerosis tend to have high suPAR levels

Patients with a disease that is a leading cause of kidney failure tend to have high levels of a particular factor circulating in their blood, according to a study appearing in an upcoming issue of the Journal of the American Society of Nephrology (JASN).

9 Nov 2012

Dopamine improves long-term memory

The feel-good hormone dopamine improves long-term memory. This is the finding of a team lead by Emrah D-zel, neuroscientist at the German Center for Neurodegenerative Diseases and the University of Magdeburg.

9 Nov 2012

HCT 1026 may help stem debilitating effects of muscular dystrophy

Cedars-Sinai Heart Institute researchers have found that an experimental compound may help stem the debilitating effects of muscular dystrophy by restoring normal blood flow to muscles affected by the genetic disorder.

9 Nov 2012

UIC researchers develop transgenic Alzheimer's mouse with apoE4 gene

Researchers at the University of Illinois at Chicago College of Medicine have developed a transgenic mouse that carries a human gene known to increase risk of Alzheimer's 15-fold. This new mouse mimics the genetics of the human disease more closely than any of the dozen existing mouse models and may prove more useful in the development of candidate drugs to prevent or treat the disease.

9 Nov 2012

New understanding of how noise can break critical tip link protein structure in inner ear cells

Researchers have mapped the precise 3-D atomic structure of a thin protein filament critical for cells in the inner ear and calculated the force necessary to pull it apart.

8 Nov 2012

ACS Prized Science video features advances in personalized medicine

Personalized medicine - the promise of customizing treatments that will work best for each individual patient - could get a boost from advances in understanding how the proteins that help determine health and disease take the three-dimensional shapes needed to work in the body. That's the message of the latest episode of the 2012 edition of a popular video series from the American Chemical Society (ACS), the world's largest scientific society.

8 Nov 2012

Simple biomarker model to predict heart failure risk

The most widely used models for predicting heart failure rely on a complex combination of lifestyle, demographic, and cardiovascular risk factor information.

8 Nov 2012

Two new EU Member States now represented within TRANSVAC services platform

In addition to the initial panel of nine services, the TRANSVAC transnational access platform has integrated in July 2012 five additional groups which provide their services to users on a free and paid basis. Two new European Union (EU) Member States are now represented within the platform of services: France and Portugal.

8 Nov 2012

Researchers discover cellular pathway that causes lung-damaging inflammation in CF

Vancouver researchers have discovered the cellular pathway that causes lung-damaging inflammation in cystic fibrosis (CF), and that reducing the pathway's activity also decreases inflammation.

8 Nov 2012

Washington University, SRI investigators launch Global Metabolomic Initiative

Investigators at Washington University and The Scripps Research Institute have announced the launch of a "Global Metabolomic Initiative" to facilitate meta-analyses on studies of the metabolism of bacteria, yeast, plants, animals and people.

7 Nov 2012

WU researchers to study blood-clotting disorders

Researchers at Washington University School of Medicine in St. Louis have received a $9 million grant to investigate blood-clotting disorders. From heart attacks and strokes to uncontrolled bleeding, clotting disorders cause more deaths each year in the United States than all types of cancer combined.

7 Nov 2012

Atpif1 gene regulates hemoglobin synthesis during red blood cell formation

Researchers at Brigham and Women's Hospital (BWH) have discovered a new gene that regulates hemoglobin synthesis during red blood cell formation. The findings advance the biomedical community's understanding and treatment of human anemias and mitochondrial disorders.

7 Nov 2012