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Scientists use next-generation protein degradation technology to study CTCF's role in transcription

CTCF is a critical protein known to play various roles in key biological processes such as transcription. Scientists at St. Jude Children's Research Hospital used a next-generation protein degradation technology to study CTCF.

26 Jan 2023

Altered gut microbiome plays a major role in the progression of endometriosis in animal model

About 196 million women worldwide suffer from endometriosis, a condition that typically causes pelvic pain and infertility.

25 Jan 2023

Researchers gain systematic insight into the organization of proteins in mitochondria

Mitochondria, the so-called powerhouse of the cells, are responsible for the energy supply of the organism and fulfill functions in metabolic and signaling processes.

25 Jan 2023

Altered amino acid metabolism could contribute to diabetes-associated peripheral neuropathy

Approximately half of people with type 1 or type 2 diabetes experience peripheral neuropathy - weakness, numbness, and pain, primarily in the hands and feet.

25 Jan 2023

Atomic-level computer model of the H1N1 virus reveals new vulnerabilities

According to the World Health Organization, each year there are an estimated 1 billion cases of influenza, between 3-5 million severe cases and up to 650,000 influenza-related respiratory deaths globally.

25 Jan 2023

Scientists illuminate how blood cancer treatments can lead to therapy-related myeloid neoplasms

Scientists at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine have illuminated how treatments for multiple myeloma and other aggressive blood cancers can lead to future malignancies, called therapy-related myeloid neoplasms (tMNs).

25 Jan 2023

New interactive tool helps to calculate risk of developing advanced breast cancer

Breast cancer is now the leading cause of global cancer incidence among women but determining who will develop breast cancer is still a challenge for the medical community.

25 Jan 2023

Injectable hydrogel composite loaded with stem cells shows success in treating perianal fistulas

In a new study using a rat model of Crohn's disease, a biodegradable hydrogel composite loaded with stem cells, developed by Johns Hopkins Medicine researchers, in a collaborative effort with the Whiting School of Engineering, has shown significant success in treating perianal fistulas (PAF) — one of the many complications of Crohn's disease.

25 Jan 2023

Scientists reveal how genetic changes lead to differences in the size of cancer cells

Cancer cells can shrink or super-size themselves to survive drug treatment or other challenges within their environment, researchers have discovered.

25 Jan 2023

Genomic screening can facilitate early detection of thyroid cancer in patients with RET gene variants

Population-based genomic screening can facilitate early detection of medullary thyroid cancer (MTC) in patients with variants in the RET gene, a new Geisinger study found.

25 Jan 2023

Process analytical technologies and monitoring inline R&D biopharma processes with Raman spectroscopy

Established in 2004, process analytical technology (PAT), a quality assurance program for the pharmaceutical industry developed by the US Food and Drug Administration, enables pharmaceutical manufacturers to control critical process parameters (CPPs).

From Thermo Fisher Scientific – Pharmaceutical and Biopharmaceutical Solutions 25 Jan 2023

New method analyzes long-range interactions in the interactome

Researchers at the Josep Carreras Leukaemia Research Institute have developed a method to analyze long-range interactions in the DNA -the interactome- from a very low amount of starting material.

25 Jan 2023

Study shows cutaneous touch neuronal cells to be critical for sexual receptiveness

Researchers studied the social relevance of G protein-coupled receptor (GPCR) Mrgprb4-lineage touch neurons in sexual touch and receptivity.

25 Jan 2023

Data demonstrates SARS-CoV-2 Omicron XBB.1.5 substantially escapes NAb responses after bivalent mRNA boosting

Researchers reported that the SARS-CoV-2 Omicron XBB.1.5 variant evades neutralizing response elicited by bivalent vaccine boosters.

25 Jan 2023

Sex-specific patterns of cytokine activation in the hippocampus post-immunological challenge

Researchers evaluated sex-based differences among cytokine and chemokine networks in the hippocampus after systemic immunological challenge.

25 Jan 2023

E-cigarette aerosols can cause cellular and molecular changes in the lungs

New research published in The FASEB Journal indicates that e-cigarettes can cause cellular and molecular changes in the lungs.

25 Jan 2023

Study suggests cortical hemorrhage in fetal brain may be associated with COVID-19

Researchers evaluated the impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections on fetal brain health.

25 Jan 2023

Cryo-electron microscopy reveals detailed blueprint of viral genome replication machinery

RNA viruses, such as the coronavirus that causes COVID-19, are in a life-and-death race the moment they infect a cell.

25 Jan 2023

Targeting newly discovered signaling pathway could boost the potency of cancer therapeutics

Cells zealously protect the integrity of their genomes, because damage can lead to cancer or cell death. The genome - a cell's complete set of DNA - is most vulnerable while it is being duplicated before a cell divides. Cancer cells constantly are dividing, so their genomes are constantly in jeopardy.

24 Jan 2023

Mosaic RBD nanoparticles offer 100% protection against SARS-CoV-2 in animal model

A recent PNAS journal study has sought to address the above-stated drawback and developed a new strategy that involves a self-assembling scaffold of proliferating cell nuclear antigen (PCNA). This technique can develop nanoparticles containing evenly incorporated heterotypic antigens.

24 Jan 2023

B Cell News and Research

Scientists use next-generation protein degradation technology to study CTCF's role in transcription

Altered gut microbiome plays a major role in the progression of endometriosis in animal model

Researchers gain systematic insight into the organization of proteins in mitochondria

Altered amino acid metabolism could contribute to diabetes-associated peripheral neuropathy

Atomic-level computer model of the H1N1 virus reveals new vulnerabilities

Scientists illuminate how blood cancer treatments can lead to therapy-related myeloid neoplasms

New interactive tool helps to calculate risk of developing advanced breast cancer

Injectable hydrogel composite loaded with stem cells shows success in treating perianal fistulas

Scientists reveal how genetic changes lead to differences in the size of cancer cells

Genomic screening can facilitate early detection of thyroid cancer in patients with RET gene variants

Process analytical technologies and monitoring inline R&D biopharma processes with Raman spectroscopy

New method analyzes long-range interactions in the interactome

Study shows cutaneous touch neuronal cells to be critical for sexual receptiveness

Data demonstrates SARS-CoV-2 Omicron XBB.1.5 substantially escapes NAb responses after bivalent mRNA boosting

Sex-specific patterns of cytokine activation in the hippocampus post-immunological challenge

E-cigarette aerosols can cause cellular and molecular changes in the lungs

Study suggests cortical hemorrhage in fetal brain may be associated with COVID-19

Cryo-electron microscopy reveals detailed blueprint of viral genome replication machinery

Targeting newly discovered signaling pathway could boost the potency of cancer therapeutics

Mosaic RBD nanoparticles offer 100% protection against SARS-CoV-2 in animal model

Industry focus eBook - Cell and gene therapy (2nd edition) eBook

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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