Preclinical News and Research

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Biovail acquires worldwide rights to Tetrabenazine

Biovail Corporation today announced a wholly owned subsidiary has entered into a definitive agreement to acquire worldwide development and commercialization rights to the entire portfolio of tetrabenazine products, including Xenazine/Nitoman (tetrabenazine tablets), and the associated intellectual property rights held by Cambridge Laboratories (Ireland) Ltd and its affiliates.

18 May 2009

Discovery of molecular pathway behind invasive prostate cancers

University of Cincinnati (UC) cancer and cell biologists have identified a new molecular pathway key to the development of invasive prostate cancers.

18 May 2009

Sodium channel-blocking agent shows promise as a potential treatment for cystic fibrosis

Cystic fibrosis patients may benefit from a new therapy that increases airway hydration, preventing the buildup of mucous, which is a key factor in the disease, according to researchers at Parion Sciences in Durham, N.C.

17 May 2009

A relationship found between cancer stem cells and prognosis in primary breast cancer

Breast cancer patients who received chemotherapy prior to surgery had heightened levels of cancer-initiating stem cells in their bone marrow, and the level of such cells correlated to a tumor's lymph node involvement, according to research from The University of Texas M. D. Anderson Cancer Center.

15 May 2009

Wistar Institute obtains U.S. patent for a novel synthetic vaccine technology

The Wistar Institute today obtained a U.S. patent for a novel synthetic vaccine technology with the potential for further development into a universal flu vaccine which could eliminate the need for annual flu shots and protect against future flu pandemics.

6 May 2009

Discovery of gene key to Alzheimer's-like reversal

A team led by researchers at MIT's Picower Institute for Learning and Memory has now pinpointed the exact gene responsible for a 2007 breakthrough in which mice with symptoms of Alzheimer's disease regained long-term memories and the ability to learn

6 May 2009

Scientists create human monoclonal antibody that neutralizes the Hepatitis C virus

Taking aim at a leading cause of liver failure in the United States, a team of scientists at the Massachusetts Biologic Laboratories (MBL) of the University of Massachusetts Medical School (UMMS) has developed a human monoclonal antibody that neutralizes the Hepatitis C virus (HCV).

5 May 2009

Discovery of genetic marker linked to the risk of acetaminophen-induced liver injury

Acetaminophen (Tylenol and generics) is one of the most commonly used over-the-counter drugs in the United States. While generally safe, acetaminophen is known to cause severe liver injury if taken in high doses. But likely due to genetics, even the recommended dose can induce serious liver damage in a significant number of people.

4 May 2009

A negative mGluR5 allosteric modulator shows efficacy in treating acute migraine attacks

When migraine strikes, because of severe pain, often accompanied by nausea and sensitivity to light and sound, sufferers are effectively disabled for up to 72 hours.

30 Apr 2009

New drug restricts the growth of neuroblastoma

Researchers from the Children's Cancer Hospital at The University of Texas M. D. Anderson Cancer Center have found a new drug that restricts the growth of neuroblastoma, a childhood brain cancer.

23 Apr 2009

Seattle Genetics presents new data on antibody-drug conjugate

Seattle Genetics, Inc. has announced that data from its antibody-drug conjugate (ADC) programs, SGN-35 and SGN-75, were presented at the 2009 Annual Meeting of the American Association for Cancer Research (AACR) being held in Denver, CO. Preclinical data with SGN-35 further elucidate its mechanism of action and demonstrate its superior antitumor activity in lymphoma compared with non-targeted agents. In addition, data with SGN-75 indicate its therapeutic potential in multiple types of solid tumors.

22 Apr 2009

Mitochondrial peptide Humanin linked to neuronal cell survival and regulation of glucose metabolism

Recent studies have shown that the mitochondrial peptide Humanin (HN) protects against neuronal cell death such as happens in Alzheimer's disease.

22 Apr 2009

FDA gives 'go ahead' for phase II clinical trials of Bryostatin for the treatment of Alzheimer's disease

The Food and Drug Administration (FDA) has given the Blanchette Rockefeller Neurosciences Institute (BRNI) the go-ahead to conduct Phase II clinical trials of Bryostatin for the treatment of Alzheimer's disease patients.

22 Apr 2009

Peregrine's PS-targeting antibodies highlighted in AACR Annual Meeting studies

Peregrine Pharmaceuticals, Inc. has reported that two preclinical studies presented during the AACR 100th Annual Meeting 2009 provided further confirmation of the immunomodulatory mechanisms contributing to the anti-tumor activity of its phosphatidylserine (PS) targeting antibodies.

22 Apr 2009

First human study of pioneering 'cell bandage' technology

A company co-founded by Professor Anthony Hollander has raised over £1.6 million to fund trials, including the first human study, of its pioneering 'cell bandage' technology, which aims to save thousands of patients from the type of knee surgery that currently leads to premature osteoarthritis.

22 Apr 2009

Novel microparticle-based immune response modifier shows broad effects against recurrent or metastatic cancer

MIS416, a novel microparticle-based immune response modifier, demonstrated the ability to significantly reduce the number and size of metastatic tumors in preclinical mouse models of lung and breast cancers, Innate Therapeutics (formerly Virionyx Corporation) announced.

22 Apr 2009

Potential new drug blocks pathway of deadliest cancer

Scientists at Cancer Research Technology Ltd (CRT) will present exciting new findings showing that a potent and selective inhibitor of protein kinase D called CRT0066101, inhibits the growth of pancreatic tumours.

20 Apr 2009

NanoBio starts clinical trial for adjuvanted intranasal flu vaccine

NanoBio has announced that the U.S. Food and Drug Administration (FDA) has approved the company's Investigational New Drug (IND) application for the Phase 1 clinical study of NB-1008, a seasonal influenza vaccine administered via a nasal dropper.

20 Apr 2009

Humanized mouse infected with HIV vaginally and rectally allows testing

The "humanized mouse" developed by Dr. J. Victor Garcia-Martinez has allowed the University of Texas Southwestern physician-scientist to conduct HIV/AIDS studies that would have been impossible without such a small animal model of HIV infection.

20 Apr 2009

Overexpression of PEA-15 protein shrinks breast cancer tumors

Overexpression of PEA-15, which binds and drags an oncoprotein out of the cell nucleus where it fuels cancer growth, steeply reduced breast cancer tumors in a preclinical experiment, researchers at The University of Texas M. D. Anderson Cancer Center reported at the 100th annual meeting of the American Association for Cancer Research.

20 Apr 2009

Preclinical News and Research

Biovail acquires worldwide rights to Tetrabenazine

Discovery of molecular pathway behind invasive prostate cancers

Sodium channel-blocking agent shows promise as a potential treatment for cystic fibrosis

A relationship found between cancer stem cells and prognosis in primary breast cancer

Wistar Institute obtains U.S. patent for a novel synthetic vaccine technology

Discovery of gene key to Alzheimer's-like reversal

Scientists create human monoclonal antibody that neutralizes the Hepatitis C virus

Discovery of genetic marker linked to the risk of acetaminophen-induced liver injury

A negative mGluR5 allosteric modulator shows efficacy in treating acute migraine attacks

New drug restricts the growth of neuroblastoma

Seattle Genetics presents new data on antibody-drug conjugate

Mitochondrial peptide Humanin linked to neuronal cell survival and regulation of glucose metabolism

FDA gives 'go ahead' for phase II clinical trials of Bryostatin for the treatment of Alzheimer's disease

Peregrine's PS-targeting antibodies highlighted in AACR Annual Meeting studies

First human study of pioneering 'cell bandage' technology

Novel microparticle-based immune response modifier shows broad effects against recurrent or metastatic cancer

Potential new drug blocks pathway of deadliest cancer

NanoBio starts clinical trial for adjuvanted intranasal flu vaccine

Humanized mouse infected with HIV vaginally and rectally allows testing

Overexpression of PEA-15 protein shrinks breast cancer tumors

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