Alzheimer's Disease News and Research

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Alzheimer's disease (AD) is an irreversible, progressive brain disease that slowly destroys memory and thinking skills and, eventually, the ability to carry out the simplest tasks of daily living. In most people with AD, symptoms first appear after age 60. AD is the most common cause of dementia among older people, but it is not a normal part of aging. Dementia refers to a decline in cognitive function that interferes with daily life and activities. AD starts in a region of the brain that affects recent memory, then gradually spreads to other parts of the brain. Although treatment can slow the progression of AD and help manage its symptoms in some people, currently there is no cure for this devastating disease.

Research may help explain Alzheimer's memory loss

Based on laboratory research, scientists at Georgetown University Medical Center have a new theory as to why people with Alzheimer's disease have trouble performing even the simplest memory tasks, such as remembering a family member's name.

16 Feb 2006

A high level of education means Alzheimer's hits later, but harder and faster

According to researchers at the Columbia University Medical Center in New York, high levels of education may help ward off Alzheimer’s disease, but they also speed up its progression once the disease has developed.

16 Feb 2006

Risk of Alzheimer's 80% genetic

In the largest twin study to date, researchers in the U.S. looked at the Swedish Twin Registry to see which factors lead to Alzheimer's disease (AD).

14 Feb 2006

NogoReceptor reduces Alzheimer's plaque

Increasing the level of a protein that plays a key role in traumatic spinal cord injuries and multiple sclerosis reduces the concentration of disease-causing plaque in Alzheimer's disease, Yale School of Medicine researchers report in the Journal of Neuroscience.

12 Feb 2006

Alzheimer's disease appears to be highly heritable

In a large study of twins, Alzheimer's disease appears to be highly heritable and genetic factors may also influence timing of the disease, according to an article in the February Archives of General Psychiatry.

9 Feb 2006

Depression linked to Alzheimer's

A lifetime history of depression is associated with increased plaques and tangles in the brains of those with Alzheimer's disease and more rapid cognitive decline, according to a study by researchers at the Alzheimer's Disease Research Center at Mount Sinai School of Medicine.

9 Feb 2006

Alzheimer disease has a genetic cause in up to 80 percent of cases

"Our finding confirms the higher estimates that have been suggested previously. The important thing is that no one has had this large a sample before," Gatz said, adding the size was 10 times that of any previous study.

7 Feb 2006

Link between dementia and cancer

By expressing a protein associated with Alzheimer's disease in the brain of the fruit fly, researchers have demonstrated an intriguing link between neuronal death and proteins previously associated with cancer.

7 Feb 2006

Abraham Lincoln may have suffered from movement disorder

Researchers at Johns Hopkins and the University of Minnesota have discovered a gene mutation in the descendants of Abraham Lincoln's grandparents that suggests the Civil War president himself might have also suffered from a disease that destroys nerve cells in the cerebellum-- the part of the brain that controls movement.

7 Feb 2006

Study finds brain changes begin gradually in 'middle age'

A study looking at brain function in young, middle-aged and older adults has identified changes in brain activity that begin gradually in middle age - and which may explain why older adults find it difficult to concentrate in busy environments and filter out irrelevant information.

7 Feb 2006

Memory loss and menopause

Women who feel that they become more forgetful as menopause approaches shouldn't just ignore it, there may be something to their own widespread reports that they're more likely to forget things as menopause approaches

5 Feb 2006

HMRI researcher lights a path to understanding brain diseases

Neurologist Mike Harrington of Pasadena, California's Huntington Medical Research Institutes argues that soon we may be able to detect brain disease before symptoms even begin. The secret is in the cerebrospinal fluid, the clear liquid that cushions our brain and spinal cord.

2 Feb 2006

Statins cut the risk of serious infection

According to scientists Cholesterol-lowering drugs, known as statins, can reduce the risk of severe infection in patients suffering from heart disease or stroke.

26 Jan 2006

Working your brain hard reduces risk of dementia

Research from the University of New South Wales (UNSW), Australia, provides the most convincing evidence to date that complex mental activity across people's lives significantly reduces the risk of dementia. The researchers found that such activity almost halves the incidence of dementia.

25 Jan 2006

Breakthrough in lupus research

A major breakthrough in lupus research - one that may fundamentally change thinking on how the disease affects behavior and cognition - was reported in the January 17, 2006 Proceedings of the National Academy of Sciences (PNAS).

25 Jan 2006

Donepezil for dementia due to Alzheimer's disease

Trials lasting up to 12 months show that taking daily doses of either 5mg or 10mg donepezil improves cognition and global clinical state in patients with Alzheimer's disease.

25 Jan 2006

Alzheimer's disease may be more common than previously recognized

A study published in the January issue of the Annals of Neurology found that neurofibrillary tangles in the substantia nigra, a part of the brain that is subject to cell loss in Parkinson's disease, are associated with gait impairment in older persons with and without dementia.

25 Jan 2006

Aricept, Razadyne and Exelon can help people with mild Alzheimer's

The Alzheimer's drugs Aricept, Razadyne and Exelon can lead to small improvements in mental functioning and the ability to carry out everyday activities in people with mild to moderate forms of the disease, according to a new review of recent studies.

25 Jan 2006

Concern over decision that new Alzheimer drugs only available for advanced disease

The recommendation by the National Institute of Clinical Evidence (NICE), that Alzheimer's drugs should be used in a minority of people with the degenerative brain disease, has created both rage and disbelief from charities and drug companies alike.

24 Jan 2006

New tool for genetic research

In an article appearing online today in the journal Nature Methods, researchers at the EPFL (Ecole Polytechnique Fidirale de Lausanne) unveil a powerful new tool that will facilitate genetic research and open up new avenues for the clinical treatment of genetic disease.

23 Jan 2006