Donepezil for dementia due to Alzheimer's disease

Trials lasting up to 12 months show that taking daily doses of either 5mg or 10mg donepezil improves cognition and global clinical state in patients with Alzheimer's disease.

This conclusion was drawn from a systematic review of 23 trials that involved a total of 5,272 participants, and is published in the latest update of The Cochrane Library.

Benefits of treatment were also seen on measures of activities of daily living and behaviour, but not on the quality of life score. The benefits are small, but for people with Alzheimer’s disease they can often be important.

Alzheimer’s disease may be involved in up to 80% of cases of dementia. Donepezil inhibits the breakdown of acetylcholine, an important neurotransmitter associated with memory, and lessens the impact of the loss of neurons in Alzheimer’s disease.

The Review Authors found that a 10mg daily dose gave only marginally greater benefit than 5mg, but produces more side effects. “Considering the better tolerability and lower costs, the lower dose may be the better option for most patients,” says lead author Jacqueline Birks who works in the Department of Clinical Geratology at the University of Oxford, UK.


The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News Medical.
Post a new comment

While we only use edited and approved content for Azthena answers, it may on occasions provide incorrect responses. Please confirm any data provided with the related suppliers or authors. We do not provide medical advice, if you search for medical information you must always consult a medical professional before acting on any information provided.

Your questions, but not your email details will be shared with OpenAI and retained for 30 days in accordance with their privacy principles.

Please do not ask questions that use sensitive or confidential information.

Read the full Terms & Conditions.

You might also like...
Hip fracture surgery may reduce mortality for dementia patients compared to non-surgical methods