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New compounds offer a two-for-one punch to fight estrogen-sensitive breast cancer

A set of compounds developed by scientists at Scripps Research in Florida target estrogen-sensitive breast cancer cells in new ways, potentially creating better options for patients with treatment-resistant cancers.

31 Aug 2021

Finding the genetic cause of childhood epilepsy helps improve treatment and care

Epilepsy is one of the most common chronic neurological diseases, affecting more than 50 million people worldwide. Although it is believed that a large proportion of childhood-onset epilepsies are caused by genetic changes, it remains unknown precisely how many of these patients suffer from a genetic disorder and how often the treatment can be targeted to their specific genetic alteration.

31 Aug 2021

FDA grants seven years of marketing exclusivity for Octapharma’s Octagam 10%

Octapharma USA today announced the U.S. Food and Drug Administration (FDA) Office of Orphan Products Development (OOPD) has awarded seven years of marketing exclusivity for Octagam® 10% [Immune Globulin Intravenous (Human)], the first and only intravenous immunoglobulin (IVIg) to be indicated for the treatment of adult dermatomyositis (DM).

31 Aug 2021

Study identifies actionable genes and candidate drugs in biliary tract cancer using a knowledgebase

Oncotarget published "Actionability evaluation of biliary tract cancer by genome transcriptome analysis and Asian cancer knowledgebase" which reported that it is necessary to investigate actionable genes and candidate drugs using a sophisticated knowledgebase and characterize BTCs immunologically for evaluating the actionability of molecular and immune therapies.

31 Aug 2021

New evidence provides strong support for the halt on prescribing hydroxychloroquine for COVID-19

In 2021, in the United States alone, there have been more than 560,000 prescriptions of hydroxychloroquine for the prevention, post-exposure and treatment of COVID-19.

31 Aug 2021

Research sheds light on potential biological mechanisms that impact adherence to medications

How strictly patients follow a prescribed drug treatment (drug adherence) is clearly important if the therapy is to have maximum effect. A number of things can affect adherence, including behavioral and socioeconomic factors, but to date there have been few investigations into the role played by genetics. Now, research to be presented at the annual conference of the European Society of Human Genetics today has thrown new light on the potential biological mechanisms that can affect adherence to treatment.

31 Aug 2021

DNMT2/TRDMT1 gene knockout may potentiate adverse effects related to drug-induced senescence

Aging-US published "The lack of functional DNMT2/TRDMT1 gene modulates cancer cell responses during drug-induced senescence" which reported that cellular senescence may be a side effect of chemotherapy and other anti-cancer treatments that may promote inflammation and paracrine secondary senescence in healthy tissues.

31 Aug 2021

Role of glycans on the SARS-CoV-2 spike protein in human receptor interaction

A team of investigators, led by Dr. Benjamin F. Mann, from Merck, USA have published a new study on the preprint server bioRxiv*. They have used a biochemical approach to control the glycosylation profile of the S protein receptor-binding domain (RBD) and to analyze the effect of different glycosylation patterns on receptor binding.

30 Aug 2021

COVID-19 vaccine elicits antibody responses in nearly 9 out of 10 people taking immunosuppressants

COVID-19 vaccination elicited antibody responses in nearly nine out of 10 people with weakened immune systems, although their responses were only about one-third as strong as those mounted by healthy people, according to a study by researchers at Washington University School of Medicine in St. Louis.

30 Aug 2021

Discovery of new urinary biomarkers can boost the surveillance of synthetic drug abuse

A team of researchers from the National University of Singapore has come up with a new solution to boost the surveillance of designer drug abuse.

30 Aug 2021

Computational study identifies human proteins structurally similar to SARS-CoV-2 proteins

A new study published in Scientific Reports identifies the human proteins that share structural similarities with the SARS-CoV-2 proteins.

30 Aug 2021

How early interferon curbs SARS-CoV-2 infection

A new study available in the Journal of Experimental Medicine focuses on the importance of interferon in SARS-CoV-2 infection.

30 Aug 2021

Intensive blood-pressure control benefits older hypertensive patients

Aggressive blood pressure treatment in older hypertensive patients lowers the incidence of cardiovascular events compared to standard therapy, without increasing adverse outcomes. That's the finding of late breaking research presented in a Hot Line session today at ESC Congress 2021.

30 Aug 2021

Combination therapy given in fixed doses can cut risk of cardiovascular disease by more than half

A combination therapy of aspirin, statins and at least two blood pressure medications given in fixed doses can slash the risk of fatal cardiovascular disease (CVD) by more than half, says an international study led by Hamilton researchers.

30 Aug 2021

What might the third wave of COVID-19 in India look like?

A new study applies mathematical modeling to understand what the third wave of the pandemic might look like in India.

29 Aug 2021

$Study identifies drug with a positive effect on heart failure patients with preserved ejection fraction$

Study identifies drug with a positive effect on heart failure patients with preserved ejection fraction

Until now, patients with heart failure with preserved ejection fraction – the most common type of heart failure in the elderly – have had no access to evidenced-based treatments. For the first time, a large clinical trial led by Prof. Dr. Stefan Anker from Charité – Universitätsmedizin Berlin has identified a drug which has a distinctly positive effect on prognosis. In patients affected by this type of heart failure, the drug – empagliflozin – reduces the risk of hospitalization or cardiovascular death by 21 percent. The results of this research have been published in the New England Journal of Medicine.

28 Aug 2021

Research analyzes the role of RNA tags in Alzheimer’s disease

Understanding the role of tau protein in Alzheimer's disease (AD) has led to new ways to diagnose it as well as the creation of medicines now in clinical trials to treat it.

28 Aug 2021

Study may pave way for new treatment strategies to limit the progression of solid tumors

Researchers at the University of British Columbia's faculty of medicine and BC Cancer Research Institute have uncovered a weakness in a key enzyme that solid tumour cancer cells rely on to adapt and survive when oxygen levels are low.

28 Aug 2021

Study discourages use of non-standard therapies for infantile spasms

Children with infantile spasms, a rare form of epileptic seizures, should be treated with one of three recommended therapies and the use of non-standard therapies should be strongly discouraged, according to a study of their effectiveness by a Weill Cornell Medicine and NewYork-Presbyterian investigator and collaborating colleagues in the Pediatric Epilepsy Research Consortium. Early treatment with an effective therapy is important for improving neurodevelopmental outcomes and, for some children, can result in permanent remission of epilepsy.

28 Aug 2021

Mobile telemedicine unit found to be effective in treating opioid use disorder in rural areas

Rural regions in the U.S. have been disproportionately affected by the opioid epidemic, while also having the fewest number of programs to treat opioid use disorder.

28 Aug 2021

Drugs News and Research

New compounds offer a two-for-one punch to fight estrogen-sensitive breast cancer

Finding the genetic cause of childhood epilepsy helps improve treatment and care

FDA grants seven years of marketing exclusivity for Octapharma’s Octagam 10%

Study identifies actionable genes and candidate drugs in biliary tract cancer using a knowledgebase

New evidence provides strong support for the halt on prescribing hydroxychloroquine for COVID-19

Research sheds light on potential biological mechanisms that impact adherence to medications

DNMT2/TRDMT1 gene knockout may potentiate adverse effects related to drug-induced senescence

Role of glycans on the SARS-CoV-2 spike protein in human receptor interaction

COVID-19 vaccine elicits antibody responses in nearly 9 out of 10 people taking immunosuppressants

Discovery of new urinary biomarkers can boost the surveillance of synthetic drug abuse

Computational study identifies human proteins structurally similar to SARS-CoV-2 proteins

How early interferon curbs SARS-CoV-2 infection

Intensive blood-pressure control benefits older hypertensive patients

Combination therapy given in fixed doses can cut risk of cardiovascular disease by more than half

What might the third wave of COVID-19 in India look like?

Study identifies drug with a positive effect on heart failure patients with preserved ejection fraction

Research analyzes the role of RNA tags in Alzheimer’s disease

Study may pave way for new treatment strategies to limit the progression of solid tumors

Study discourages use of non-standard therapies for infantile spasms

Mobile telemedicine unit found to be effective in treating opioid use disorder in rural areas

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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