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Singapore researchers find common therapeutic vulnerability for a deadly blood cancer

CML is a blood cancer that can be controlled by continuously taking an expensive type of medicine called a tyrosine kinase inhibitor (TKI). In almost all patients, stopping TKI treatment results in recurrence of CML.

18 Mar 2020

Research demonstrates control mechanism of force-induced cell-to-cell attachment

Using the amphibian Xenopus laevis as a model, Drs. Noriyuki Kinoshita and Naoto Ueno from the National Institute for Basic Biology, Japan and Dr. Ileana Cristea from Princeton University, USA have demonstrated that physical forces, such as centrifugal force, enhance cell-to-cell attachment and increase the stiffness of embryonic tissues as a result of force-induced cell shape change.

18 Mar 2020

Drug from scorpion venom could offer hope for children with fetal alcohol spectrum disorder

A research team led by Children's National Hospital faculty was able to "rescue" a pre-clinical model of fetal alcohol spectrum disorder in juvenile models, reversing motor skill deficits with the help of a novel drug derived from scorpion venom.

18 Mar 2020

Researchers identify new way to treat Danon disease using gene therapy

Danon disease is a very rare, life-threatening condition where the fundamental biological process of removing and recycling proteins does not work.

18 Mar 2020

Researchers study how changing seasons will affect coronavirus spread

One of the biggest unknowns about the coronavirus is how changing seasons will affect its spread. Physicists from the University of Utah have received the university's first COVID-19-related grant to tackle the question.

18 Mar 2020

Using 'organs-on-a-chip' to study chronic inflammatory diseases

MIT biological engineers have created a multitissue model that lets them study the relationships between different organs and the immune system, on a specialized microfluidic platform seeded with human cells.

18 Mar 2020

Bacterial extracellular vesicles could combat antibiotic resistance

Children's National Hospital researchers for the first time have isolated bacterial extracellular vesicles from the blood of healthy donors, a critical step to better understanding the way gut bacteria communicate with the rest of the body via the bloodstream.

18 Mar 2020

Novel Alzheimer's risk genes affect microglial response to amyloid-beta

Our DNA determines a large part of our risk for Alzheimer's disease, but it remained unclear how many genetic risk factors contribute to disease.

18 Mar 2020

MCL1 protein essential in protecting the intestine against cancer development

An international team of researchers from the University of Zurich, the University Hospital Zurich, Heidelberg and Glasgow has identified a novel function for the cell death regulating protein MCL1: It is essential in protecting the intestine against cancer development – independent of bacterial-driven inflammation.

18 Mar 2020

Woman's risk for negative mood, executive dysfunction after ovary removal linked to childhood adversity

Nearly one-third of women who choose to have their ovaries removed before the natural age of menopause are susceptible to negative mood and executive dysfunction.

18 Mar 2020

Researchers identify genetic signature linked to higher risk of preeclampsia

Researchers at Baylor College of Medicine have identified a genetic signature combining certain maternal and fetal gene variants that are associated with a higher risk of preeclampsia.

17 Mar 2020

Researchers elucidate new mechanism for controlling DNA methylation in cells

Why normal cells turn into cancer cells One of the factors is deeply related to the failure of the cell differentiation mechanism called DNA methylation.

17 Mar 2020

Researchers develop new kind of CRISPR screen technology to target RNA

CRISPR-based genetic screens have helped scientists identify genes that are key players in sickle-cell anemia, cancer immunotherapy, lung cancer metastasis, and many other diseases.

16 Mar 2020

U-M startup offers free coronavirus sequencing kits for researchers

As doctors, scientists and governments try to get a grip on COVID-19, the University of Michigan startup Arbor Biosciences is providing free kits to capture the genetic code of virus samples.

16 Mar 2020

Scientists discover link between Parkinson's and gene targeted by blue-green algae toxin

Scientists have discovered a possible link between Parkinson's disease and a gene impacted by a neurotoxin found in blue-green algae.

16 Mar 2020

Max Planck researchers identify mechanistic basis of antigen receptor gene assembly

Adaptive immunity is a powerful defense mechanism in vertebrates. A finely tuned interplay of different cell types provides a pathogen-specific immune response to eliminate for example bacteria and viruses.

13 Mar 2020

MicroRNA dysregulation has critical impacts on development, inflammation and cancer development

Oncotarget Volume 11, Issue 10 reported that dysregulation of noncoding micro RNA molecules has been associated with immune cell activation in the context of Helicobacter pylori-induced gastric inflammation as well as carcinogenesis, but also with downregulation of mismatch repair genes, and may interfere with immune checkpoint proteins that lead to the overexpression of antigens on gastric tumor cells.

13 Mar 2020

Genes News and Research

Singapore researchers find common therapeutic vulnerability for a deadly blood cancer

Research demonstrates control mechanism of force-induced cell-to-cell attachment

Drug from scorpion venom could offer hope for children with fetal alcohol spectrum disorder

Researchers identify new way to treat Danon disease using gene therapy

Researchers study how changing seasons will affect coronavirus spread

Using 'organs-on-a-chip' to study chronic inflammatory diseases

Bacterial extracellular vesicles could combat antibiotic resistance

Novel Alzheimer's risk genes affect microglial response to amyloid-beta

MCL1 protein essential in protecting the intestine against cancer development

Woman's risk for negative mood, executive dysfunction after ovary removal linked to childhood adversity

Researchers identify genetic signature linked to higher risk of preeclampsia

Researchers elucidate new mechanism for controlling DNA methylation in cells

Researchers develop new kind of CRISPR screen technology to target RNA

U-M startup offers free coronavirus sequencing kits for researchers

Scientists discover link between Parkinson's and gene targeted by blue-green algae toxin

Max Planck researchers identify mechanistic basis of antigen receptor gene assembly

MicroRNA dysregulation has critical impacts on development, inflammation and cancer development

SPRK1 enzyme plays role in reorganizing the paternal genome during fertilization

Blood stem cells conserve epigenetic memory of previous infections to boost immunity

Researchers reveal nerve circuitry regulating worms' response to changing temperatures

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