Protein C News and Research

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A circRNA COVID vaccine with potential to neutralize SARS-CoV-2 variants

Researchers demonstrate the broad neutralization potential of a strategically engineered circRNA using mice as a model system.

21 Mar 2022

Using CRISPR/Cas to develop biosafety materials

Researchers discuss the use of the highly efficient CRISPR/Cas technologies to identify viral genome sequences for biosafety purposes.

21 Mar 2022

Research reveals enzyme-driven process that activates anti-cancer molecule

Years of toil in the laboratory have revealed how a marine bacterium makes a potent anti-cancer molecule.

21 Mar 2022

Mount Sinai launches phase 1 study to evaluate the safety, immunogenicity of egg-based COVID-19 vaccine

A team of clinical investigators at the Icahn School of Medicine at Mount Sinai has announced the launch of a Phase 1, open-label, placebo-controlled study to evaluate the safety and immunogenicity of an egg-based COVID-19 vaccine in healthy, vaccinated adults who have never been infected with COVID-19.

21 Mar 2022

Researchers offer a clear picture of how the 9-1-1 clamp is recruited to sites of DNA damage

DNA is often likened to a blueprint. The particular sequence of As, Cs, Gs, and Ts in DNA provides information for building an organism.

21 Mar 2022

Oral drug that reverses immune aging effectively prevents death in COVID-19 mouse model

The immune system deteriorates with age, making COVID-19 particularly deadly in older people - but to date, no clinically available medication addresses this key risk factor.

21 Mar 2022

LJI study may open the door to new Parkinson's treatments and diagnostics

Scientists at La Jolla Institute for Immunology have found that people with Parkinson's disease have a clear "genetic signature" of the disease in their memory T cells.

21 Mar 2022

Study explores novel antiviral activity of PAD inhibitors against human beta-coronaviruses HCoV-OC43 and SARS-CoV-2

In a new study, researchers aimed to determine if peptidyl-arginine deiminases inhibitors may be used as a novel class of host-targeting antivirals against human coronaviruses.

21 Mar 2022

Study evaluates colorimetric sensors for SARS-CoV-2 detection using gold nanoparticles

A new study reported the development of colorimetric sensors for the detection of SARS-CoV-2 ribonucleic acid-dependent RNA polymerase, envelope, and spike genes.

21 Mar 2022

Glycogen synthase kinase-3 inhibitors found to attenuate COVID-19-associated cytokine storm

In a new study, researchers investigated whether the SARS-CoV-2 spike protein and its S2 subunit induced the expression of C–X–C motif chemokine 10, a subset of cytokine.

21 Mar 2022

Phase 2 trial evaluates the safety and immunogenicity of two doses of the SARS-CoV-2 vaccine MVC-COV1901 in adolescents

A recent study evaluated the safety and immunogenicity of a COVID-19 vaccine in a phase II trial.

21 Mar 2022

Study aimed to identify the direct pathway that associates integrins with vascular dysregulation during SARS-CoV-2 infection

Researchers demonstrated the role of integrin signaling in vascular dysfunction associated with SARS-CoV-2 infection.

21 Mar 2022

The importance of the endosomal pathway for SARS-CoV-2 entry

Researchers demonstrated that combined inhibition of cell-surface-based and endosomal pathways completely blocked SARS-CoV-2 entry into mammalian cells.

21 Mar 2022

Biological timeline of COVID-19 immune recovery described in new research

In a recent study published on the bioRxiv* preprint server, a group of researchers from the University of California, San Francisco, looked at intra-patient immunological changes over time to see if there were any changes in immune responses associated with successful COVID-19 resolution.

21 Mar 2022

Substantial alteration in gut microbiome observed in children with with MIS-C and COVID

A team of scientists from Turkey has recently evaluated the diversity and composition of gut microbiota in children diagnosed with multisystem inflammatory syndrome (MIS-C) and acute coronavirus disease 2019 (COVID-19). They have observed significant alteration in the gut microbiota composition in children with MIS-C. These changes are associated with autoimmunity, metabolic dysfunction, and obesity.

21 Mar 2022

Protein C News and Research

A circRNA COVID vaccine with potential to neutralize SARS-CoV-2 variants

Using CRISPR/Cas to develop biosafety materials

Research reveals enzyme-driven process that activates anti-cancer molecule

Mount Sinai launches phase 1 study to evaluate the safety, immunogenicity of egg-based COVID-19 vaccine

Researchers offer a clear picture of how the 9-1-1 clamp is recruited to sites of DNA damage

Oral drug that reverses immune aging effectively prevents death in COVID-19 mouse model

LJI study may open the door to new Parkinson's treatments and diagnostics

Study explores novel antiviral activity of PAD inhibitors against human beta-coronaviruses HCoV-OC43 and SARS-CoV-2

Study evaluates colorimetric sensors for SARS-CoV-2 detection using gold nanoparticles

Glycogen synthase kinase-3 inhibitors found to attenuate COVID-19-associated cytokine storm

Phase 2 trial evaluates the safety and immunogenicity of two doses of the SARS-CoV-2 vaccine MVC-COV1901 in adolescents

Study aimed to identify the direct pathway that associates integrins with vascular dysregulation during SARS-CoV-2 infection

The importance of the endosomal pathway for SARS-CoV-2 entry

Biological timeline of COVID-19 immune recovery described in new research

Substantial alteration in gut microbiome observed in children with with MIS-C and COVID

Sex-specific differences in T-cell responses to COVID-19

Multiple inter-variant recombination events identified in Omicron subvariants

Response to COVID-19 boosters in seronegative multiple sclerosis patients

How does the non-structural protein 1 affect COVID-19 pathogenicity?

Omicron BA.1.1 and BA.2 subvariants with new mutations in New Zealand and Hong Kong

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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