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New gene therapy to treat cancer in children, young adults offers hopes and challenges

The first gene therapy for cancer, approved by the Food Drug Administration in August, will transform the treatment of a particular kind of cancer in children and young adults. It's transformative because it uses a patient's own immune cells to attack the cancer cells.

3 Oct 2017

FDA approves Verzenio for advanced metastatic breast cancer

The U.S. Food and Drug Administration (FDA) has approved a new drug Verzenio (abemaciclib) for the treatment of advanced or metastatic hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative breast cancer.

2 Oct 2017

Benefits of Biomarkers in Colorectal Cancer Treatment

Biomarkers fall into different categories: diagnostic biomarkers, are used to identify a disease; prognostic biomarkers, help clinicians to determine, for example, whether you're more likely to die or have problems with a disease; and there are some that can be used to inform treatment, to determine whether one therapy would be more successful than another.

2 Oct 2017

Study sheds light on the mechanism of lung damage in premature babies

The lungs are one of the last organs to undergo full maturation in a baby's body. Children that are born very prematurely do not have fully developed lungs, and are therefore more susceptible to associated complications.

30 Sep 2017

Out-of-pocket costs often keep pricey new cholesterol drugs out of reach, study finds

Access to powerful new cholesterol-lowering drugs is so tightly controlled and patients' out-of-pocket costs are so high that fewer than a third of people whose doctors prescribe the drugs get them, a new study found.

30 Sep 2017

Study identifies potential biomarker for onset, progression of MS

An article published in Experimental Biology and Medicine identifies Opioid Growth Factor (OGF) as a novel biomarker for the onset and progression of multiple sclerosis (MS).

27 Sep 2017

Cellular messaging mechanism could lead to new way of treating disease

A newly discovered cellular messaging mechanism could lead to a new way to deliver therapeutics to tissues affected by disease, according to a new study from Harvard T.H. Chan School of Public Health.

27 Sep 2017

Drug combination produces synergistic effect against growth of triple-negative breast cancer

In the hunt for novel treatments against an aggressive form of breast cancer, researchers combined a new protein inhibitor with a chemotherapy drug to create a powerful combination that resulted in cancer cell death.

26 Sep 2017

SBP researcher awarded $10.8 million grant to pursue development of new drug for substance abuse

Sanford Burnham Prebys Medical Discovery Institute is pleased to announce the National Institute on Drug Abuse at the National Institutes of Health has awarded Nicholas Cosford, Ph.D., a three-year, $10.8 million grant to pursue the preclinical development of a new class of medicine to treat substance use disorders.

26 Sep 2017

Existing drugs may be able to improve therapy for chronic myeloid leukemia, mice study shows

Two drugs, already approved for safe use in people, may be able to improve therapy for chronic myeloid leukemia (CML), a blood cancer that affects myeloid cells, according to results from a University of Iowa study in mice.

26 Sep 2017

Seizures can be induced by cannabinoids, scientists warn

Marijuana is the most commonly abused drug in the world, and the advent of synthetic cannabinoids creates additional challenges to the society because of their higher potency and ability to escape drug detection screenings.

21 Sep 2017

Researchers design novel small antibody fragment with improved crystallizability

Antibodies are a powerful weapon system in defending our body against invaders such as bacteria and viruses. Each antibody consists of four polypeptide chains: two heavy chains and two light chains joined to form a Y-shaped molecule.

21 Sep 2017

Poliovirus therapy triggers longer-lasting immune response against malignant tumors

An investigational therapy using modified poliovirus to attack cancer tumors appears to unleash the body's own capacity to fight malignancies by activating an inflammation process that counter's the ability of cancer cells to evade the immune system.

20 Sep 2017

Researchers propose new treatment strategy for colon cancer patients

Colorectal cancer is the fourth leading cause of cancer-related deaths worldwide. In a new study, researchers demonstrate for the first time that a previously uncharacterized protein is increased in colon cancer. The protein is immunoglobulin containing proline rich receptor-1 (IGPR-1) which was recently identified in the same laboratory as a cell adhesion molecule.

20 Sep 2017

Researchers identify role of tumor-infiltrating B-cells in melanoma progression, resistance to therapy

In a multi-institutional collaborative study, scientists at The Wistar Institute and the Medical University of Vienna, Austria, have identified the role of tumor-infiltrating or tumor-associated B-cells ("TABs") in melanoma progression and resistance to targeted therapy.

20 Sep 2017

Beta blockers offer no additional benefit for heart attack patients who take other drugs

A new study from the University of North Carolina at Chapel Hill finds beta blockers are not needed after a heart attack if heart-attack survivors are taking ACE inhibitors and statins.

19 Sep 2017

Epidemiologist to advance research on hormonal markers for better prediction of breast cancer risk

Epidemiologist Susan Hankinson at the University of Massachusetts Amherst has received a five-year, $4.2 million grant from the National Cancer Institute to build upon and advance her research group's earlier work to identify and validate hormonal markers to better predict the risk of invasive breast cancer in postmenopausal women.

19 Sep 2017

Scientists discover markers for progressive multiple sclerosis

Scientists have uncovered two closely related cytokines -- molecules involved in cell communication and movement -- that may explain why some people develop progressive multiple sclerosis (MS), the most severe form of the disease.

18 Sep 2017

A skin patch to get rid of those love handles

Researchers from the Columbia University Medical Center (CUMC) and the University of North Carolina have managed to devise a microneedle skin patch that could locally treat both obesity and diabetes. As of now it has been used to treat mice in the laboratory and shown promising results.

17 Sep 2017

Steroid hormones could provide new insight into age-related bone loss

A group of steroid hormones could provide new insight into the bone loss and deterioration that occurs with aging, researchers at the Medical College of Georgia at Augusta University report.

15 Sep 2017

Receptor News and Research

New gene therapy to treat cancer in children, young adults offers hopes and challenges

FDA approves Verzenio for advanced metastatic breast cancer

Benefits of Biomarkers in Colorectal Cancer Treatment

Study sheds light on the mechanism of lung damage in premature babies

Out-of-pocket costs often keep pricey new cholesterol drugs out of reach, study finds

Study identifies potential biomarker for onset, progression of MS

Cellular messaging mechanism could lead to new way of treating disease

Drug combination produces synergistic effect against growth of triple-negative breast cancer

SBP researcher awarded $10.8 million grant to pursue development of new drug for substance abuse

Existing drugs may be able to improve therapy for chronic myeloid leukemia, mice study shows

Seizures can be induced by cannabinoids, scientists warn

Researchers design novel small antibody fragment with improved crystallizability

Poliovirus therapy triggers longer-lasting immune response against malignant tumors

Researchers propose new treatment strategy for colon cancer patients

Researchers identify role of tumor-infiltrating B-cells in melanoma progression, resistance to therapy

Beta blockers offer no additional benefit for heart attack patients who take other drugs

Epidemiologist to advance research on hormonal markers for better prediction of breast cancer risk

Scientists discover markers for progressive multiple sclerosis

A skin patch to get rid of those love handles

Steroid hormones could provide new insight into age-related bone loss

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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