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Keystone molecules in chemical communication, defense have dominant consequences in nature

Naturally occurring "keystone" molecules that have powerful behavioral effects on diverse organisms often play large but unrecognized roles in structuring ecosystems, according to a theory proposed in the June issue of BioScience.

20 May 2013

Changes in specific proteins contribute to 'leaky-gut' wall

Scientists at Trinity College Dublin have made an important advance in understanding the biological factors that keep the lining of the gut wall intact. Associate Professor, Maria O'Sullivan at Trinity's School of Medicine and St James's Hospital and colleagues, showed that changes in specific proteins may contribute to a 'leaky-gut' wall which may have important implications for common chronic digestive diseases such as irritable bowel syndrome and inflammatory bowel disease.

17 May 2013

Study suggests need for better anti-rejection therapies

Transplant researchers at the University of Pittsburgh School of Medicine challenge a long-held assumption about how biologic pathways trigger immune system rejection of donor organs in a report published online today in the Journal of Clinical Investigation.

16 May 2013

Researchers demonstrate how EGF accelerates division of cell nucleus

Biologists at Heidelberg University have discovered new approaches for the treatment of cancer. They investigated how a special signalling molecule, the epidermal growth factor (EGF), stimulates the separation of chromosomes in the cell. The researchers were able to demonstrate that EGF accelerates the division of the cell nucleus, i.e. mitosis, as well as boosts precision in chromosome segregation.

15 May 2013

Vijay Tiwari from IMB receives Bruno Speck Award from Swiss Foundation of Haematological Research

Dr Vijay Tiwari, a Group Leader at the Institute of Molecular Biology (IMB) in Mainz, has been awarded the Bruno Speck Award by the Swiss Foundation of Haematological Research. The award recognises outstanding work by young scientists in the fields of haematology and stem cell research.

15 May 2013

Findings could help develop new approaches to treat depression and memory loss in the elderly

Scientists have known for some time that exercise induces neurogenesis in a specific brain region, the hippocampus. However, until this study, the underlying mechanism was not fully understood.

14 May 2013

Inhibiting powerful protein with new agents may supply broad benefit for lymphoma patients

A soon-to-be-tested class of drug inhibitors were predicted to help a limited number of patients with B-cell lymphomas with mutations affecting the EZH2 protein.

14 May 2013

Discovery provides vital clues for new antibiotics against MRSA

Scientists at Imperial College London have identified four new proteins that act as receptors for an essential signalling molecule in bacteria such as MRSA.

14 May 2013

Researchers identify microRNA-155 as prognostic marker, treatment target in patients with AML

A study has identified microRNA-155 as a new independent prognostic marker and treatment target in patients with acute myeloid leukemia that has normal-looking chromosomes under the microscope (that is, cytogenetically normal acute myeloid leukemia, or CN-AML).

14 May 2013

Research on total anomalous pulmonary venous connection

Total anomalous pulmonary venous connection, one type of "blue baby" syndrome, is a potentially deadly congenital disorder that occurs when pulmonary veins don't connect normally to the left atrium of the heart.

13 May 2013

Researchers successfully test new anti-cocaine vaccine in primates

Researchers at Weill Cornell Medical College have successfully tested their novel anti-cocaine vaccine in primates, bringing them closer to launching human clinical trials.

13 May 2013

Disease-in-a-dish models show promise for treating ataxia telangiectasia

Led by Dr. Peiyee Lee and Dr. Richard Gatti, researchers at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have used induced pluripotent stem cells to advance disease-in-a-dish modeling of a rare genetic disorder, ataxia telangiectasia.

13 May 2013

Researchers reveal how genes are turned on and off during early human development

A large, multi-institutional research team involved in the NIH Epigenome Roadmap Project has published a sweeping analysis in the current issue of the journal Cell of how genes are turned on and off to direct early human development.

10 May 2013

Drug resistant brain tumors: an interview with Prof. Mischel, Ludwig Institute for Cancer Research and Prof. Bensinger, University of California

In cancer, mutations in proteins that control cell growth are common, leading to unrestrained cellular proliferation and tumor formation.

9 May 2013

Protein tumor necrosis factor-alpha is a powerful weapon to control cancer

The protein tumor necrosis factor-alpha (TNF-alpha) is a powerful weapon in the arsenal to control cancer. Unfortunately, as is the case with many potent cancer therapies, the use of TNF-alpha as an anti-cancer therapy has been severely limited.

8 May 2013

Scientists identify TR4 protein that drives the formation of pituitary tumors in Cushing's disease

Scientists at the Salk Institute for Biological Studies have identified a protein that drives the formation of pituitary tumors in Cushing's disease, a development that may give clinicians a therapeutic target to treat this potentially life-threatening disorder.

8 May 2013

Research discovery may lead to effective new treatments for neurodegenerative disease

UCLA researchers led by Drs. Peiyee Lee and Richard Gatti at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research have used induced pluripotent stem cells to advance disease-in-a-dish modeling of a rare genetic disorder, Ataxia Telangiectasia.

8 May 2013

Kinase inhibitors: an interview with Jan Hoflack, CSO of Oncodesign

Kinase inhibitors are molecules that block the activity of kinases. Kinases are a specific class of enzymes. They are extremely important in signal transduction processes in the human body meaning that they actually regulate most of the physiological processes that take place in the body.

7 May 2013

Neuroperspective reviews status and prospects of therapeutics for Parkinson's disease

NI Research, the leading publisher of independent research on the neurotherapeutics industry, has released the May issue of NeuroPerspective, which reviews the status and prospects of therapeutics for Parkinson's.

7 May 2013

Novel screening method for identifying inhibitors of EZH2 methyltransferase

Tumor repressor genes, which inhibit tumor formation, can be "turned off" due to undesirable molecular changes affecting the chromosomes on which the genes reside. Understanding and being able to control these alterations could lead to new approaches for activating or inactivating genes linked to cancer.

5 May 2013

Molecule News and Research

Keystone molecules in chemical communication, defense have dominant consequences in nature

Changes in specific proteins contribute to 'leaky-gut' wall

Study suggests need for better anti-rejection therapies

Researchers demonstrate how EGF accelerates division of cell nucleus

Vijay Tiwari from IMB receives Bruno Speck Award from Swiss Foundation of Haematological Research

Findings could help develop new approaches to treat depression and memory loss in the elderly

Inhibiting powerful protein with new agents may supply broad benefit for lymphoma patients

Discovery provides vital clues for new antibiotics against MRSA

Researchers identify microRNA-155 as prognostic marker, treatment target in patients with AML

Research on total anomalous pulmonary venous connection

Researchers successfully test new anti-cocaine vaccine in primates

Disease-in-a-dish models show promise for treating ataxia telangiectasia

Researchers reveal how genes are turned on and off during early human development

Drug resistant brain tumors: an interview with Prof. Mischel, Ludwig Institute for Cancer Research and Prof. Bensinger, University of California

Protein tumor necrosis factor-alpha is a powerful weapon to control cancer

Scientists identify TR4 protein that drives the formation of pituitary tumors in Cushing's disease

Research discovery may lead to effective new treatments for neurodegenerative disease

Kinase inhibitors: an interview with Jan Hoflack, CSO of Oncodesign

Neuroperspective reviews status and prospects of therapeutics for Parkinson's disease

Novel screening method for identifying inhibitors of EZH2 methyltransferase

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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