Cartilage News and Research

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Cartilage is a stiff yet flexible connective tissue found in many areas in the bodies of humans and other animals, including the joints between bones, the rib cage, the ear, the nose, the elbow, the knee, the ankle, the bronchial tubes and the intervertebral discs.

Nanofiber scaffolds regenerate protein components in cartilage repair

Johns Hopkins tissue engineers have used tiny, artificial fiber scaffolds thousands of times smaller than a human hair to help coax stem cells into developing into cartilage, the shock-absorbing lining of elbows and knees that often wears thin from injury or age. Reporting online June 4 in the Proceedings of the National Academy of Sciences, investigators produce an important component of cartilage in both laboratory and animal models.

18 Jul 2012

PRP therapy safe and effective method of treatment for athletes with cartilage tears

When it comes to treating cartilage tears in athletes, Platelet Rich Plasma (PRP) therapy is a safe and effective method of treatment, according to research presented today at the American Orthopaedic Society for Sports Medicine's (AOSSM) Annual Meeting in Baltimore.

16 Jul 2012

Study demonstrates superiority of AE technique for ACL reconstruction in children

A new study demonstrates the superiority of a specific technique to perform anterior cruciate ligament (ACL) reconstruction in children. In recent years, the number of ACL surgeries in pediatric athletes has skyrocketed.

13 Jul 2012

AOSSM to present ten research awards and seven grants during annual meeting in Baltimore

In order to recognize and encourage cutting-edge research in key areas of orthopaedic sports medicine, the American Orthopaedic Society for Sports Medicine (AOSSM) will present ten research awards and seven grants during its Annual Meeting, July 12-15 in Baltimore, MD. As a leader in orthopaedic sports medicine, AOSSM annually provides more than $350,000 to research initiatives and projects around the country.

12 Jul 2012

Osteoarthritis gene tic markers identified

Scientists have used data from the Arthritis Research UK Osteoarthritis Genetics study to identify five gene loci significantly associated with the development of the disease.

10 Jul 2012

New epigenetic path toward a cure for osteoarthritis

In what could be a breakthrough in the practical application of epigenetic science, U.K. scientists used human tissue samples to discover that those with osteoarthritis have a signature epigenetic change (DNA methylation) responsible for switching on and off a gene that produces a destructive enzyme called MMP13.

7 Jul 2012

Epigenetic changes due to methylation play a key role in altering genes in RA

It's not just our DNA that makes us susceptible to disease and influences its impact and outcome. Scientists are beginning to realize more and more that important changes in genes that are unrelated to changes in the DNA sequence itself - a field of study known as epigenetics - are equally influential.

4 Jul 2012

Osteoarthritis susceptibility: eight potential genes discovered

The largest genome-wide association study (GWAS) of osteoarthritis to date, published Online First in The Lancet, has uncovered eight new genetic variants or loci that appear to increase susceptibility to the most common form of arthritis, which affects about 40% of the world population older than 70 years. These findings bring the total number of osteoarthritis susceptibility genes isolated in European populations to 11.

3 Jul 2012

Data from Infinity’s IPI-145 pre-clinical study on inflammatory diseases

Infinity Pharmaceuticals, Inc. today reported preclinical data for IPI-145, the company's oral inhibitor of phosphoinositide-3-kinase (PI3K)-delta and PI3K-gamma. The data demonstrate potent PI3K-delta and -gamma inhibition in biochemical, cellular and whole blood assays and activity in multiple preclinical models of inflammatory disease, including rheumatoid arthritis and asthma.

28 Jun 2012

Implantable sensor technology and cartilage scaffolding systems for bone and joint repair

A group of biomedical engineering researchers have cited recent advances in implantable sensor technology and cartilage scaffolding systems as major developments in the use of engineered cartilage for bone and joint repair.

27 Jun 2012

Wake Forest Baptist researchers achieve early milestone in lab-engineered kidney project

Regenerative medicine researchers at Wake Forest Baptist Medical Center have reached an early milestone in a long-term project that aims to build replacement kidneys in the lab to help solve the shortage of donor organs.

23 Jun 2012

Biomimedica closes Series-B financing

Biomimedica, Incorporated, a medical device start-up company focused on the development and commercialization of its proprietary GRADION Total Cartilage Replacement technology, announced today that it has closed its Series-B financing, raising $11.9 million from a combination of new and existing investors, including conversion of approximately $2.8 million in bridge loans.

22 Jun 2012

Georgia Tech startup to create new delivery method for cell-based therapies

Cell-based therapies have yet to reach their full potential in repairing damaged tissue because of the hostile environment the cells face once injected into the body. A patient's inflammatory response normally causes the majority of these therapeutic cells to die or migrate away from the area in need of repair.

14 Jun 2012

New method enhances adhesion of injected CECs for successful corneal transplantation

Regenerative medicine, or the use of specially grown tissues and cells to treat injuries and diseases, has been successful in treating disorders of a number of organs, including heart, pancreas, and cartilage. However, efforts to treat disorders of the corneal endothelium, a single cell layer on the inner surface of the cornea, with regenerative techniques have been less effective. Now, a group of scientists has developed a method that enhances the adhesion of injected corneal endothelial cells (CECs), allowing for successful corneal transplantation to repair pathological dysfunctions.

14 Jun 2012

Utah-based company licenses new biomedical device from BYU for chronic back pain

In between the vertebrae of the human spine are 23 Oreo-sized, cartilage-filled discs that hold the vertebrae together and allow for spine movement. While the discs are critical for movement, they can become the source of back pain when they degenerate or herniate - a major health problem that affects 85% of Americans and drains the U.S. economy to the tune of $100 billion every year.

13 Jun 2012

Higher quality bone from stem cells

UCLA stem cell scientists purified a subset of stem cells found in fat tissue and made from them bone that was formed faster and was of higher quality than bone grown using traditional methods, a finding that may one day eliminate the need for painful bone grafts that use material taken from the patient during invasive procedures.

11 Jun 2012

Cartilage News and Research

Further Reading

Nanofiber scaffolds regenerate protein components in cartilage repair

PRP therapy safe and effective method of treatment for athletes with cartilage tears

Study demonstrates superiority of AE technique for ACL reconstruction in children

AOSSM to present ten research awards and seven grants during annual meeting in Baltimore

Osteoarthritis gene tic markers identified

New epigenetic path toward a cure for osteoarthritis

Epigenetic changes due to methylation play a key role in altering genes in RA

Osteoarthritis susceptibility: eight potential genes discovered

Data from Infinity’s IPI-145 pre-clinical study on inflammatory diseases

Implantable sensor technology and cartilage scaffolding systems for bone and joint repair

Wake Forest Baptist researchers achieve early milestone in lab-engineered kidney project

Biomimedica closes Series-B financing

Georgia Tech startup to create new delivery method for cell-based therapies

New method enhances adhesion of injected CECs for successful corneal transplantation

Utah-based company licenses new biomedical device from BYU for chronic back pain

Higher quality bone from stem cells

Piramal to present data on several molecular imaging compounds at SNM annual meeting

Biomarkers predict progressive spinal damage in ankylosing spondylitis

What are vitamins?

Targeting stem cells might be more effective in treating vascular disease

Event guide: 4th Extra-Hepatic Lipid-Based Nanoparticles Delivery Summit eBook

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How Omics Technologies Are Transforming Biological Research and Drug Discovery

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