Kinase News and Research

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Importance of Numb-associated kinases in SARS-CoV-2 infection

A new study posted to the bioRxiv* preprint server has focussed on assessing four members of the NAK family that are associated with SARS-CoV-2 infection. These kininases could act as a target for the development of effective COVID-19 therapeutics.

23 Mar 2022

Glycogen synthase kinase-3 inhibitors found to attenuate COVID-19-associated cytokine storm

In a new study, researchers investigated whether the SARS-CoV-2 spike protein and its S2 subunit induced the expression of C–X–C motif chemokine 10, a subset of cytokine.

21 Mar 2022

Innate and adaptive immune responses to BNT162b2 vaccination in mice

Researchers analyzed the innate and adaptive responses to the mRNA-based BNT162b2 COVID-19 vaccine in mice.

18 Mar 2022

Can cardiac biomarkers determine COVID-19 prognosis?

Researchers review prognostic cardiac biomarkers in COVID-19 patients.

15 Mar 2022

Bioactive small molecules enhance CRISPR/Cas9 loss-of-function editing in human cells

Researchers demonstrate enhanced loss-of-function editing of CRISPR/Cas9 in human cells.

14 Mar 2022

Novel genetic relationships with severe SARS-CoV-2

Researchers discovered multiple novel genetic processes underpinning severe COVID-19 using genome-wide association studies and meta-analyses.

11 Mar 2022

Researchers solve the structure of large signaling protein involved in emergence of blood cancers

Researchers led by Christopher Garcia of the Ludwig Center at Stanford University have solved the long-sought structure of a large signaling protein involved in responses to infection, inflammation, the generation of immune cells and when dysregulated by mutation - the emergence of blood cancers known as myeloproliferative neoplasms.

11 Mar 2022

Exploring biomedical literature and clinical trial records to identify new drug combinations for COVID-19 treatment

Researchers extensively searched publicly available SARS-CoV-2 biomedical literature to identify drug combinations that could effectively treat COVID-19.

7 Mar 2022

Diabetes and the mTOR pathway in COVID-19 patients

A new study discusses the possible etiopathogenetic mechanisms associated with diabetes that could enhance the severity of COVID-19.

6 Mar 2022

Disruption of sleep and circadian rhythm can increase the chances of contracting a virus

A recent study explores the effect of sleep and circadian rhythm dispersion on mouse lung transcriptome after six of hours sleep deprivation.

6 Mar 2022

Adenosine receptor agonists provide therapeutic target in mouse SARS-CoV-2 infection

A new study describes the efficacy of adenosine receptor agonists in the treatment of SARS-CoV-2 infection.

2 Mar 2022

Targeting a specific protein can help prevent or delay prostate cancer progression

Targeting a specific protein that is often overexpressed in prostate cancer can help prevent or delay the disease from spreading to other parts of the body, according to a study led by Cedars-Sinai Cancer investigators.

25 Feb 2022

Cell-mediated immune response among inflammatory bowel disease patients after mRNA COVID-19 vaccination

Researchers evaluated CMIR in IBD patients following immunization with two doses of COVID-19 vaccine.

25 Feb 2022

Study shows how certain RNA molecules control the repair of damaged DNA in cancer cells

A new study from Karolinska Institutet in Sweden shows how certain RNA molecules control the repair of damaged DNA in cancer cells, a discovery that could eventually give rise to better cancer treatments. The study is published today in the journal Nature Communications.

23 Feb 2022

Discovery could lead to new treatment approach for people with alcohol-associated liver disease

Investigators at Cedars-Sinai have uncovered a new pathway that helps explain how consuming too much alcohol causes damage to the liver, specifically mitochondrial dysfunction in alcohol-associated liver disease.

22 Feb 2022

Study suggests non-classical inhibition of TBK1/IKKε is protective against severe COVID-19 immunopathology in vivo

A study posted suggested the inhibition of TBK1 and its homolog KKε could decrease the severity of COVID-19.

21 Feb 2022

Study identifies a protein complex critical for regulating apoptosis and necroptosis

Cell death plays an important role in normal human development and health but requires tightly orchestrated balance to avert disease. Too much can trigger a massive inflammatory immune response that damages tissues and organs. Not enough can interfere with the body's ability to fight infection or lead to cancer.

18 Feb 2022

Response of peripheral immune cells to ex vivo SARS-CoV-2 exposure compared to SARS-CoV

Researchers characterized the responses of the PBMCs at the individual cell and cell type levels against SARS-CoV-2 and SARS-CoV ex vivo.

18 Feb 2022

Use of immunosuppressants for inflammatory rheumatic diseases and the associated risk of severe COVID-19

A recent study posted to the medRxiv* preprint server investigated the risk of severe/fatal coronavirus disease 2019 (COVID-19) in patients treated with immunosuppressants for inflammatory rheumatic diseases (IRD).

15 Feb 2022

Cardiovascular markers for predicting clinical outcomes in SARS-CoV-2 infection

In a recent study posted to the medRxiv* preprint server, an interdisciplinary team of researchers from Toronto, Canada, characterized the markers of endothelial function and developed micro ribonucleic acid (miRNA) expression atlas in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-positive and -negative patients admitted to the intensive care unit (ICU).