Mouse Model News and Research

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Scientist receives $6.8M grant to study how environmental chemicals increase CVD risk

Exposure to environmental chemicals, including those in common plastic products, has been linked with an increased risk of cardiovascular disease, or CVD, the leading cause of death worldwide. According to the World Health Organization, 17.9 million people died from CVDs in 2019.

16 Aug 2023

Researchers design one-step procedure for improving effective of adoptive cell immunotherapy against solid tumors

Researchers developed a one-step method to engineer multifunctional M1 phenotype macrophages.

14 Aug 2023

Glucokinase activators induce hepatic lipid accumulation in mice with high-fat diet

The researchers demonstrated that glucokinase activation was effective in lowering blood glucose in mice with high-fat diet-induced obesity, while it potentially raised the risk of increasing hepatic lipid accumulation that triggered the PERK-UPR pathway.

11 Aug 2023

Genetically diverse mice reveal key differences in innate immune responses to SARS-CoV-2

Researchers at The Jackson Laboratory have created a panel of genetically diverse mice that accurately model the highly variable human response to SARS-CoV-2 infection.

11 Aug 2023

New mechanism discovered for brain repair after ischemic stroke

Patients often experience functional decline after an ischemic stroke, especially due to the brain's resistance to regenerate after damage.

10 Aug 2023

New gene-editing tool helps to study single-base mutations in cancer

A change in just one letter in the code that makes up a cancer-causing gene can significantly affect how aggressive a tumor is or how well a patient with cancer responds to a particular therapy.

10 Aug 2023

Study provides clues to how harmful T cells cause heart disease

Scientists can finally hunt down a harmful kind of human T cell, thanks to new research led by scientists at La Jolla Institute for Immunology (LJI) and the Medical College of Georgia (MCG) at Augusta University.

10 Aug 2023

Scientists develop novel animal model of neurobrucellosis

Neurobrucellosis is a severe long-term complication of brucellosis, one of the most common bacterial zoonotic diseases.

10 Aug 2023

Stem cell transplants may be a promising therapeutic against Alzheimer's, study shows

In the ongoing search for a cure for Alzheimer's disease, a burgeoning branch of medicine is bringing new hope. Stem cell therapies are already being used to treat various cancers and disorders of the blood and immune system.

9 Aug 2023

Yale researchers create "humanized" liver in living mice to study chronic liver diseases

Yale researchers have created a functional "humanized" liver in living mice that will help scientists find human-specific mechanisms for regulating cholesterol levels and potentially for treating chronic liver diseases afflicting tens of millions of people in the United States.

9 Aug 2023

Mice lacking TMCO3 gene have shortened bones

Through next-generation sequencing, investigators have identified a mutation in the TMCO3 gene in two sisters with short stature.

9 Aug 2023

Mass spectrometry-based secretome approach reveals key players in astroglial barrier function

In neuroinflammation, immune cells such as leukocytes cross the blood-brain barrier. One key to this is the gelatinases matrix metalloproteinase (MMP)-2 and -9. Until now, the substrates of these enzymes involved in the process were unknown.

9 Aug 2023

Are mushrooms an effective early dietary intervention for Alzheimer’s Disease?

In a study published in the journal Foods, researchers reviewed available literature on the potential anti-Alzheimer's disease properties of mushrooms.

9 Aug 2023

CAR-T immune therapies could be effective against solid tumors

CAR-T immune therapies could be effective against solid tumors if the right targets are identified, a new study led by University of Illinois Urbana-Champaign researchers suggests.

3 Aug 2023

Dopamine neurons may play a bigger role in motor control than previously thought

Dopamine: It's not just for rewards anymore. In a new Northwestern University-led study, researchers identified and recorded from three genetic subtypes of dopamine neurons in the midbrain region of a mouse model.

3 Aug 2023

Study sheds light on mechanisms behind a rare disease found almost exclusively in boys

A University of Ottawa-led research team has published rigorous new research that advances a quest to understand a puzzling – and heartbreaking – ultra-rare disease that's found almost exclusively in boys.

3 Aug 2023

Can genome editing transform ocular disease treatment?

The discovery and development of gene-editing technologies and their applications in managing ocular diseases.

3 Aug 2023

Study reveals two key mechanisms underlying high risks from lung infections in Down syndrome

Individuals with Down syndrome, the genetic condition caused by triplication of human chromosome 21, also known as trisomy 21, display a very high risk of hospitalization and mortality after developing lung infections.

2 Aug 2023

TTUHSC researcher receives $1.76 million grant to investigate new pancreatic cancer treatment

With a survival rate in the single digits, pancreatic ductal adenocarcinoma (PDAC) is highly lethal. In fact, by the time PDAC is clinically diagnosed, it is already considered incurable via surgery or other means in up to 90% of patients.

2 Aug 2023

Monoclonal antibody shows promise in slowing progression of ALS

New research reveals a type of monoclonal antibody already tested in certain forms of cancer may be a promising treatment in stopping the progression of amyotrophic lateral sclerosis, or ALS, a fatal neurodegenerative disease.

31 Jul 2023

Mouse Model News and Research

Scientist receives $6.8M grant to study how environmental chemicals increase CVD risk

Researchers design one-step procedure for improving effective of adoptive cell immunotherapy against solid tumors

Glucokinase activators induce hepatic lipid accumulation in mice with high-fat diet

Genetically diverse mice reveal key differences in innate immune responses to SARS-CoV-2

New mechanism discovered for brain repair after ischemic stroke

New gene-editing tool helps to study single-base mutations in cancer

Study provides clues to how harmful T cells cause heart disease

Scientists develop novel animal model of neurobrucellosis

Stem cell transplants may be a promising therapeutic against Alzheimer's, study shows

Yale researchers create "humanized" liver in living mice to study chronic liver diseases

Mice lacking TMCO3 gene have shortened bones

Mass spectrometry-based secretome approach reveals key players in astroglial barrier function

Are mushrooms an effective early dietary intervention for Alzheimer’s Disease?

CAR-T immune therapies could be effective against solid tumors

Dopamine neurons may play a bigger role in motor control than previously thought

Study sheds light on mechanisms behind a rare disease found almost exclusively in boys

Can genome editing transform ocular disease treatment?

Study reveals two key mechanisms underlying high risks from lung infections in Down syndrome

TTUHSC researcher receives $1.76 million grant to investigate new pancreatic cancer treatment

Monoclonal antibody shows promise in slowing progression of ALS

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