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New study provides more clarity about giving steroids during pediatric open-heart surgery

For more than four decades, doctors have been split on whether giving steroids during a pediatric open-heart surgery could be helpful for post-operative recovery.

6 Nov 2022

UAB researchers report lack of predictability for fecal microbial transplants without prior antibiotic therapy

A fecal microbial transplant - giving a recipient fecal matter from a donor to change the recipient's gut microbial community in the colon - has been a successful last resort therapy for people with recurrent Clostridium difficile infection after multiple rounds of suppressive antibiotics have eliminated the recipient microbial community.

4 Nov 2022

Gut colonization by proteobacteria modulates mice’s neurobehavioral response to cocaine

A new study revealed that gut colonization by proteobacteria modulates cocaine neurobehavioral response in mice.

3 Nov 2022

Personalized approach to kidney disease screening for T1D patients could enable earlier disease detection

Taking a personalized approach to kidney disease screening for people with type 1 diabetes (T1D) may reduce the time that chronic kidney disease goes undetected, according to a new analysis performed by the Epidemiology of Diabetes Interventions and Complications study group, which is funded by the National Institute of Diabetes and Digestive and Kidney Diseases, part of the National Institutes of Health.

2 Nov 2022

First pig-to-human cardiac transplant alters heart's electrical signals

A recent study to be presented at the American Heart Association (AHA) Scientific Sessions 2022* revealed unexpected changes in the electrical conduction system of the first genetically-modified porcine-to-human heart xenotransplant.

1 Nov 2022

COVID-19 positive hearts may be safe for transplantation

A recent study soon to be presented at the American Heart Association (AHA) Scientific Sessions 2022* suggests that hearts from coronavirus disease 2019 (COVID-19)-positive (COVID-19+) donors may be safe for transplantation.

1 Nov 2022

High incidence of CKD in the United States persists, study says

New onset chronic kidney disease (CKD) in people with diabetes is highest among racial and ethnic minority groups compared with white persons, a UCLA-Providence study finds.

1 Nov 2022

COVID-19-positive donor hearts appear to be safe for transplantation

Donor hearts from people who were COVID-19-positive appeared to be as safe for transplantation as those from people without COVID-19, according to a short-term analysis to be presented at the American Heart Association's Scientific Sessions 2022.

31 Oct 2022

Cleveland Clinic awarded $12 million NIH grant to define how cytokines regulate inflammation

Cleveland Clinic's Lerner Research Institute was awarded a five-year $12 million grant by the National Cancer Institute, part of the National Institutes of Health, to define how cytokines - proteins produced during immune response - regulate inflammation and interact with cells and molecules surrounding tumors.

28 Oct 2022

First anti-SARS Cov2 monoclonal antibody candidate of SpikImm demonstrates excellent tolerance

SPK001, the first anti-SARS Cov2 monoclonal antibody candidate of SpikImm, a French biotechnology company founded by Truffle Capital, originally discovered by the Institut Pasteur's Human Immunology Laboratory, directed by Dr. Hugo Mouquet (Inserm Joint Research Unit), has been tested on three initial cohorts of healthy volunteers, and has demonstrated excellent tolerance, in the context of the Phase 1 clinical study, recently labeled as a "national priority" by CAPNET (National Steering Committee for Therapeutic Trials and other Research on Covid-19).

28 Oct 2022

Study shows how Toxoplasma parasite successfully spreads in the body

The parasite Toxoplasma is carried by a large portion of the global human population. Now a study led by researchers at Stockholm University shows how this microscopic parasite so successfully spreads in the body, for example to the brain

28 Oct 2022

Rehabilitation plus stem cell grafting after spinal cord injury can augment functional outcomes

In recent years, researchers have made measurable progress, using animal models, to promote tissue regeneration in spinal cord injuries (SCI) through implanted neural stem cells or grafts. Other efforts have shown that intensive physical rehabilitation can improve function after SCI by promoting greater or new roles for undamaged or spared cells and neural circuits.

28 Oct 2022

Researchers use CRISPR-edited T cells to treat seriously ill children with resistant leukaemia

Researchers at Great Ormond Street Hospital for Children (GOSH) and UCL Great Ormond Street Institute of Child Health (UCL GOS ICH) have used CRISPR/Cas9 technology to engineer donor T cells to try to treat seriously ill children with resistant leukaemia, who had otherwise exhausted all available therapies.

27 Oct 2022

Study shows the potential of experimental monoclonal antibodies to treat Epstein-Barr virus infection

A panel of investigational monoclonal antibodies (mAbs) targeting different sites of the Epstein-Barr virus (EBV) blocked infection when tested in human cells in a laboratory setting.

27 Oct 2022

Pioneering gene editing technique can repair faulty T cells in patients with CTLA-4 insufficiency

A fault in cells that form a key part of the immune system can be repaired with a pioneering gene editing technique, finds new research demonstrated in human cells and mice, led by UCL scientists.

27 Oct 2022

Harmless group of bacteria linked with increased risk of death in patients with end-stage renal disease

A big group of bacteria found in our soil, our water and our showerheads are harmless for most of us, but a new study indicates they are associated with an increased risk of dying in individuals whose kidneys have failed.

25 Oct 2022

Researchers streamline way to manufacture CAR T-cells in just 24 hours

Researchers at University Hospitals (UH) Seidman Cancer Center and a biotech start-up company have developed a streamlined way to manufacture CAR T-cells for immunotherapy treatment in just 24 hours – an improvement over the team's previous benchmark of eight days and commercial suppliers that typically take three weeks.

25 Oct 2022

Transplant News and Research

New study provides more clarity about giving steroids during pediatric open-heart surgery

UAB researchers report lack of predictability for fecal microbial transplants without prior antibiotic therapy

Gut colonization by proteobacteria modulates mice’s neurobehavioral response to cocaine

Personalized approach to kidney disease screening for T1D patients could enable earlier disease detection

First pig-to-human cardiac transplant alters heart's electrical signals

COVID-19 positive hearts may be safe for transplantation

High incidence of CKD in the United States persists, study says

COVID-19-positive donor hearts appear to be safe for transplantation

Cleveland Clinic awarded $12 million NIH grant to define how cytokines regulate inflammation

First anti-SARS Cov2 monoclonal antibody candidate of SpikImm demonstrates excellent tolerance

Study shows how Toxoplasma parasite successfully spreads in the body

Rehabilitation plus stem cell grafting after spinal cord injury can augment functional outcomes

Researchers use CRISPR-edited T cells to treat seriously ill children with resistant leukaemia

Study shows the potential of experimental monoclonal antibodies to treat Epstein-Barr virus infection

Pioneering gene editing technique can repair faulty T cells in patients with CTLA-4 insufficiency

Harmless group of bacteria linked with increased risk of death in patients with end-stage renal disease

Researchers streamline way to manufacture CAR T-cells in just 24 hours

Collaborative research paves a new way to better health for patients with enlarged hearts

Effectiveness of COVID-19 vaccines in preventing hospitalizations among immunocompromised adults

Competition may play important role in brain evolution, killifish study shows

Improving healthcare sustainability through carbon data

Managing vibration in IVF laboratories

A New Approach to Preventing Bladder Cancer Recurrence

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