Enzyme News and Research

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Tyk2 enzyme helps regulate obesity through differentiation of brown adipose tissue

Approximately 68 percent of U.S. adults are overweight or obese, according to the National Cancer Institute, which puts them at greater risk for developing cancer, cardiovascular disease, diabetes and a host of other chronic illnesses. But an international team of scientists led by Virginia Commonwealth University Massey Cancer Center researcher Andrew Larner, M.D., Ph.D., has successfully reversed obesity in mice by manipulating the production of an enzyme known as tyrosine-protein kinase-2 (Tyk2).

6 Dec 2012

University of Florida initiates enrollment in SPI-1005 Phase II trial for sensorineural hearing loss

The University of Florida (UF) has started enrolling subjects in a new study testing the oral drug developed by Sound Pharmaceuticals, Inc. (SPI-1005) to prevent hearing loss caused by loud music. Loud music or noise can induce temporary and permanent auditory threshold shifts (TTS or PTS).

6 Dec 2012

Selective targeting of neurotransmitters may allow for new medication therapies for GI conditions

Selective targeting of the neurotransmitter that differentially affects brain cells that control the two distinct functions of the pancreas may allow for new medication therapies for conditions like diabetes, dyspepsia and gastro-esophageal reflux, according to Penn State College of Medicine researchers.

5 Dec 2012

Sourdough and enzyme bioprocessing effectively modify flavor, texture of oat breads

The health-promoting properties of whole grain oat have made it a desirable ingredient for use in breads. However, the absence of gluten-forming proteins and high fibre content pose technological challenges with respect to product texture. Fundamental understanding about the role of oat components on the structure formation of dough and bread is needed to facilitate the development of new healthy variants of oat breads with consumer appealing properties.

5 Dec 2012

Researchers investigate GPER receptor as possible new drug target for breast cancer

Five-year breast cancer survival rates have improved dramatically over the past 50 years, but tumors can recur up to ten or more years after they are detected. When tumors recur, they are even more difficult to treat.

5 Dec 2012

psi-GSH prevents neurodegeneration associated with Alzheimer's in mouse model

Researchers at the University of Minnesota's Center for Drug Design have developed a synthetic compound that, in a mouse model, successfully prevents the neurodegeneration associated with Alzheimer's disease.

4 Dec 2012

New research finds bisphenol A in fetal liver tissues

New research from the University of Michigan School of Public Health found BPA, or bisphenol A, in fetal liver tissue, demonstrating that there is considerable exposure to the chemical during pregnancy.

4 Dec 2012

Merck commences MK-8931 Phase II/III trial in Alzheimer's

Merck, known as MSD outside the United States and Canada, announced it has started a Phase II/III clinical trial designed to evaluate the safety and efficacy of MK-8931 versus placebo in patients with mild-to-moderate Alzheimer's disease.

3 Dec 2012

Pain can be treated by targeting immune and nerve cells outside brain or spinal cord

The treatment of inflammatory pain can be improved by endogenous opioid peptides acting directly in injured tissue. Scientists at the Charité - Universitätsmedizin Berlin and the Université Paris Descartes showed that pain can be successfully treated by targeting immune and nerve cells outside the brain or spinal cord.

3 Dec 2012

Scientists determine how two proteins help create organelles

Scientists at The Scripps Research Institute (TSRI) have determined how two proteins help create organelles, or specialized subunits within a cell, that play a vital role in maintaining cell health. This discovery opens the door for research on substances that could interfere with the formation of these organelles and lead to new therapies for cancer.

2 Dec 2012

L-Fucose slows down and even reverses age-related skin developments

With increasing age the human skin shows a considerable loss of resistance and elasticity. These changes in skin texture, which are one of the main reasons for the appearance of wrinkles, is the age induced loss of skin thickness and the related degradation of elastin fibers within the skin. It has been proven that L-Fucose - a scarce sugar - slows down and even reverses age-related skin developments.

2 Dec 2012

Scientists sequence DNA of biopsied tissue from colon polyps

The causes underlying the development of certain types of common cancers have not yet been elucidated. In order to better determine the origin and the sequence of events responsible for the onset of colon cancer, the teams led by Thanos Halazonetis and Stylianos Antonarakis, professors at the University of Geneva (UNIGE), Switzerland, have sequenced the DNA of biopsied tissue from colon polyps.

2 Dec 2012

Study examines role of inflammation in chronic fatigue syndrome

A new study published in the current issue of Psychotherapy and Psychosomatics has examined the role of inflammation in chronic fatigue syndrome, a disorder that affects many people and does not seem to have an explanation that is likely to yield satisfactory treatment.

1 Dec 2012

HDAC6 enzyme could be possible target for therapies against Alzheimer's

Scientists from the DZNE sites in G-ttingen and Bonn, the UMG as well as from the US participated in this basic research project on Alzheimer's disease. The study is published in "EMBO Molecular Medicine".

30 Nov 2012

DFG to establish 11 Collaborative Research Centres in Jan 2013

The Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) will establish eleven Collaborative Research Centres (CRCs) as of 1 January 2013. This was decided by the responsible Grants Committee during its fall session in Bonn.

30 Nov 2012

Physicians beware of fruity drug interactions

An understanding of the potential for pharmacokinetic interaction between orally administered drugs and grapefruit is necessary in view of an increase in marketed medications that fit the risk criteria, suggest Canadian researchers.

30 Nov 2012

New insights into POT-1/TTP-1 protein complex

New insights into a protein complex that regulates the very tips of chromosomes could improve methods of screening anti-cancer drugs.

30 Nov 2012

Novel SIRT2 inhibitor protects against neuronal damage in animal models of Huntington's

Treatment with a novel agent that inhibits the activity of SIRT2, an enzyme that regulates many important cellular functions, reduced neurological damage, slowed the loss of motor function and extended survival in two animal models of Huntington's disease.

30 Nov 2012

Epizyme to present data from DOT1L and EZH2 inhibitor programs at 54th ASH annual meeting

Epizyme, Inc., a biopharmaceutical company leading the creation of personalized therapeutics to treat patients with genetically defined cancers, today announced the presentation of data evaluating the preclinical safety and efficacy of two of the Company's novel, potent and selective small molecule inhibitors. These inhibitors individually target DOT1L and EZH2, members of a class of epigenic enzymes called histone methyltransferases (HMTs).

30 Nov 2012

AstraZeneca receives FDA approval for Cometriq to treat medullary thyroid cancer

The U.S. Food and Drug Administration today approved Cometriq (cabozantinib) to treat medullary thyroid cancer that has spread to other parts of the body (metastasized).

29 Nov 2012

Enzyme News and Research

Tyk2 enzyme helps regulate obesity through differentiation of brown adipose tissue

University of Florida initiates enrollment in SPI-1005 Phase II trial for sensorineural hearing loss

Selective targeting of neurotransmitters may allow for new medication therapies for GI conditions

Sourdough and enzyme bioprocessing effectively modify flavor, texture of oat breads

Researchers investigate GPER receptor as possible new drug target for breast cancer

psi-GSH prevents neurodegeneration associated with Alzheimer's in mouse model

New research finds bisphenol A in fetal liver tissues

Merck commences MK-8931 Phase II/III trial in Alzheimer's

Pain can be treated by targeting immune and nerve cells outside brain or spinal cord

Scientists determine how two proteins help create organelles

L-Fucose slows down and even reverses age-related skin developments

Scientists sequence DNA of biopsied tissue from colon polyps

Study examines role of inflammation in chronic fatigue syndrome

HDAC6 enzyme could be possible target for therapies against Alzheimer's

DFG to establish 11 Collaborative Research Centres in Jan 2013

Physicians beware of fruity drug interactions

New insights into POT-1/TTP-1 protein complex

Novel SIRT2 inhibitor protects against neuronal damage in animal models of Huntington's

Epizyme to present data from DOT1L and EZH2 inhibitor programs at 54th ASH annual meeting

AstraZeneca receives FDA approval for Cometriq to treat medullary thyroid cancer

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