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Study paves the way to a new drug design concept

Hydrogen peroxide reacts with copper to produce hydroxyl radicals with strong antibacterial properties. However, this requires high copper concentrations because two copper atoms have to come close together, which occurs by chance.

31 Jul 2021

UVA researchers overturn conventional wisdom on action of key hormone receptors within cells

Researchers at the University of Virginia School of Medicine have overturned conventional wisdom on the workings of vital hormone receptors within cells, a finding that could boost drug development for diabetes and related metabolic disorders, cancer and other diseases.

31 Jul 2021

Newly identified genetic mutation causes rare, early onset inflammatory bowel disease

Johns Hopkins Medicine researchers, in collaboration with national and international researchers, have identified a genetic mutation in a small number of children with a rare type of inflammatory bowel disease.

30 Jul 2021

Researchers test a library of lipid-based compounds to enable safe delivery of RNA drugs to the lungs

Hokkaido University researchers in Japan created and tested a library of lipid-based compounds to find a way to safely and effectively deliver RNA drugs to the lungs.

30 Jul 2021

Diabetes drug’s new weight loss formula fuels cost-benefit debate

The long list of side effects that follow ads for the newer expensive drugs to treat Type 2 diabetes sometimes include an unusual warning: They might cause weight loss. That side effect is one that many people — especially those with Type 2 diabetes, which is associated with obesity — may desperately want.

30 Jul 2021

In-silico prediction of effective drug combinations for the treatment of SARS-CoV-2 infection

A new study published on the bioRxiv preprint server has developed the first computational model, i.e., a signaling network model, that can predict effective repurposed drug combinations to treat different phases of COVID-19 disease. This study has focused on identifying drugs for the treatment of early- and late-stage severe disease.

30 Jul 2021

Drug combination could make curative surgery possible for some liver cancer patients

A combination of the kinase-inhibitor drug cabozantinib and the immunotherapy drug nivolumab can make curative surgery possible in some liver cancer patients who would normally not be considered surgery candidates.

29 Jul 2021

Pfizer court fight could legalize Medicare copays and unleash ‘gold rush’ in sales

Three years ago, pharma giant Pfizer paid $24 million to settle federal allegations that it was paying kickbacks and inflating sales by reimbursing Medicare patients for out-of-pocket medication costs.

29 Jul 2021

Mini-antibodies efficiently block SARS-CoV-2 virus

Göttingen researchers have developed mini-antibodies that efficiently block the coronavirus SARS-CoV-2 and its dangerous new variants.

28 Jul 2021

First interchangeable biosimilar insulin product approved by FDA for treatment of diabetes

Today, the U.S. Food and Drug Administration approved the first interchangeable biosimilar insulin product, indicated to improve glycemic control in adults and pediatric patients with Type 1 diabetes mellitus and in adults with Type 2 diabetes mellitus.

28 Jul 2021

Natural compound prevents, reverses brain damage linked to Parkinson's disease in mice

Johns Hopkins Medicine researchers say they have added to evidence that the compound farnesol, found naturally in herbs, and berries and other fruits, prevents and reverses brain damage linked to Parkinson's disease in mouse studies.

28 Jul 2021

China earns a malaria-free certification from WHO

Following a 70-year effort, China has been awarded a malaria-free certification from WHO – a notable feat for a country that reported 30 million cases of the disease annually in the 1940s.

28 Jul 2021

Women say California insurer makes it too hard to get drug for postpartum depression

When Miriam McDonald decided she wanted to have another baby at age 44, her doctor told her she had a better chance of winning the lottery. So when she got pregnant right away, she and her husband were thrilled. But within three days of giving birth to their son, in September 2019, everything shifted.

28 Jul 2021

Nine of ten patients with hypertension do not receive enough treatment

Hypertension (high blood pressure) is the leading treatable cause of illness and death worldwide. More than a billion people are hypertensive, defined as having blood pressure (BP) with a systolic level (the higher number) of at least 140 millimeters of mercury (mmHg) or diastolic level (the lower number) of 90 mmHg or higher.

28 Jul 2021

Oncotarget data reveals retinoic acid as fundamental regulator of cell cycle and differentiation

Oncotarget published "Role for Fgr and Numb in retinoic acid-induced differentiation and G0 arrest of non-APL AML cells" which reported that retinoic acid is a fundamental regulator of cell cycle and cell differentiation.

28 Jul 2021

SARS-CoV-2 variants of concern employ different strategies of antibody escape

A recent study in the field of fluid analysis reveals a diverse set of strategies utilized by alpha and beta variants of the severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) in order to evade antibodies generated during an earlier infection with this virus. The paper is currently available on the bioRxiv* preprint server while it undergoes a peer-review process.

28 Jul 2021

Machine learning models that include social determinants of health better predict cardiovascular outcomes

Machine learning can accurately predict cardiovascular disease and guide treatment--but models that incorporate social determinants of health better capture risk and outcomes for diverse groups, finds a new study by researchers at New York University's School of Global Public Health and Tandon School of Engineering.

27 Jul 2021

International collaboration aims to develop better therapy for childhood acute lymphoblastic leukemia

Scientists at St. Jude Children's Research Hospital are working with colleagues in China to develop better therapy for childhood acute lymphoblastic leukemia (ALL).

27 Jul 2021

Umbilical cord-derived mesenchymal stem cells show promise to treat muscular dystrophies

Results of a compassionate-use study released in STEM CELLS Translational Medicine show promising results for treating muscular dystrophies with mesenchymal stem cells (MSCs) derived from Wharton's jelly (WJ), a substance found in the umbilical cord. Led by doctors at Klara Medical Center (KMC), Czestochowa, Poland, these WJ-MSC treatments resulted in significant improvement in several body muscles in most of the patients, with no serious side effects.

27 Jul 2021

Return to play can be managed for athletes with genetic heart diseases, study suggests

Receiving the diagnosis of a genetic heart disease such as long QT syndrome, which can cause sudden cardiac death, has long been a game-ender for young athletes. But a 20-year study at Mayo Clinic following such athletes who were allowed to return to play suggests that the risks can be managed through a shared decision-making process.

27 Jul 2021

Drugs News and Research

Study paves the way to a new drug design concept

UVA researchers overturn conventional wisdom on action of key hormone receptors within cells

Newly identified genetic mutation causes rare, early onset inflammatory bowel disease

Researchers test a library of lipid-based compounds to enable safe delivery of RNA drugs to the lungs

Diabetes drug’s new weight loss formula fuels cost-benefit debate

In-silico prediction of effective drug combinations for the treatment of SARS-CoV-2 infection

Drug combination could make curative surgery possible for some liver cancer patients

Pfizer court fight could legalize Medicare copays and unleash ‘gold rush’ in sales

Mini-antibodies efficiently block SARS-CoV-2 virus

First interchangeable biosimilar insulin product approved by FDA for treatment of diabetes

Natural compound prevents, reverses brain damage linked to Parkinson's disease in mice

China earns a malaria-free certification from WHO

Women say California insurer makes it too hard to get drug for postpartum depression

Nine of ten patients with hypertension do not receive enough treatment

Oncotarget data reveals retinoic acid as fundamental regulator of cell cycle and differentiation

SARS-CoV-2 variants of concern employ different strategies of antibody escape

Machine learning models that include social determinants of health better predict cardiovascular outcomes

International collaboration aims to develop better therapy for childhood acute lymphoblastic leukemia

Umbilical cord-derived mesenchymal stem cells show promise to treat muscular dystrophies

Return to play can be managed for athletes with genetic heart diseases, study suggests

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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